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UniProtKB - Q8I2N6 (Q8I2N6_PLAF7)

Entry version 98 (25 May 2022)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Fumarate hydratase

Gene

PF3D7_0927300

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseImportedARBA annotation
Ligand4Fe-4SARBA annotation, Iron, Iron-sulfur, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Fumarate hydrataseImported (EC:4.2.1.2Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0927300Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		PlasmoDB:PF3D7_0927300

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q8I2N6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q8I2N6, 1 interactor

STRING: functional protein association networks

More...STRINGi		5833.PFI1340w

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8I2N6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8I2N6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini132 – 464FumeraseInterPro annotationAdd BLAST333
Domaini470 – 678Fumerase_CInterPro annotationAdd BLAST209

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-I fumarase family.ARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_026758_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8I2N6

Identification of Orthologs from Complete Genome Data

More...OMAi		AGVLPMC

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8I2N6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004646, Fe-S_hydro-lyase_TtdA-typ_cat
IPR004647, Fe-S_hydro-lyase_TtdB-typ_cat
IPR036660, Fe-S_hydroAse_TtdB_cat_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05681, Fumerase, 1 hit
PF05683, Fumerase_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF117457, SSF117457, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00723, ttdB_fumA_fumB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I2N6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKFKEASIL LSHKNAYLQY NLYFKKIRCV YHKIYRRHMN SLNSFIDILS 
        60         70         80         90        100
FRNEDDIEYK KVEDLSKYIE VIKINKSPMN ETKYYGYNFK EEYNFLDEHG 
       110        120        130        140        150
NIKEYIYNEN KKLLYKNYEK EYIHIPPFVL TKLCEYAFKE ILFFLNKKHL 
       160        170        180        190        200
KQLQHILQDK ESSKNDKYVA MTLIKNAIIS SEQKLPGCQD TGTAIILGKK 
       210        220        230        240        250
DEDILTTYEH KYLTLGVYNA YKYNNFRYSQ LSPLNMFNEV NTKNNLPCQI 
       260        270        280        290        300
EIYTNIKKEK LHEVQQNEYP NHMKDIQNNN NVKHNKDITT RQIDSKENQK 
       310        320        330        340        350
STKKQNVDFL YDGPKYELIF IAKGGGSANK TFLFQQTKSI LNEENLYNFL 
       360        370        380        390        400
LDKIKEIGTS ACPPYHLAIV IGGLSAEMNL KMVKLASCRY LDNLKTEGGI 
       410        420        430        440        450
YGKAFRDLES EKIILQKAQS LGIGAQFGGK YFVHDVRVIR LPRHSASCPI 
       460        470        480        490        500
GIGVSCSADR QIKCLINKNG VFMQMLEHEP IKYLPEITFK DLNQENAVKI 
       510        520        530        540        550
DLNQNMEQTL KTLSKYPTST LVLLTGKLVV ARDSAHKKIV DQFINDNVPI 
       560        570        580        590        600
PEYFKKYPIY YAGPAKTPDN YASGSFGPTT AGRMDAYAEV LMKNNASLIS 
       610        620        630        640        650
LAKGNRSAVV RNACKKYNGF YLGSIGGPGA ILAKNNIKNV QVIDFKDMGM 
       660        670        680 
EAVHLIDVVD FPAFIVIDNK GNDFYNKWLP S
Length:681
Mass (Da):78,396
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7BA7801AD7F14EE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL844508 Genomic DNA Translation: CAD51954.1

NCBI Reference Sequences

More...RefSeqi		XP_001352143.1, XM_001352107.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		CAD51954; CAD51954; PF3D7_0927300

Database of genes from NCBI RefSeq genomes

More...GeneIDi		813548

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		pfa:PF3D7_0927300

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844508 Genomic DNA Translation: CAD51954.1
RefSeqiXP_001352143.1, XM_001352107.1

3D structure databases

AlphaFoldDBiQ8I2N6
SMRiQ8I2N6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8I2N6, 1 interactor
STRINGi5833.PFI1340w

Proteomic databases

PRIDEiQ8I2N6

Genome annotation databases

EnsemblProtistsiCAD51954; CAD51954; PF3D7_0927300
GeneIDi813548
KEGGipfa:PF3D7_0927300

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_0927300

Phylogenomic databases

HOGENOMiCLU_026758_0_0_1
InParanoidiQ8I2N6
OMAiAGVLPMC
PhylomeDBiQ8I2N6

Family and domain databases

Gene3Di3.20.130.10, 1 hit
InterProiView protein in InterPro
IPR004646, Fe-S_hydro-lyase_TtdA-typ_cat
IPR004647, Fe-S_hydro-lyase_TtdB-typ_cat
IPR036660, Fe-S_hydroAse_TtdB_cat_sf
PfamiView protein in Pfam
PF05681, Fumerase, 1 hit
PF05683, Fumerase_C, 1 hit
SUPFAMiSSF117457, SSF117457, 2 hits
TIGRFAMsiTIGR00723, ttdB_fumA_fumB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I2N6_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I2N6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 25, 2022
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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