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Protein
Submitted name:

TFIIH basal transcription factor complex helicase XPD subunit

Gene

PF3D7_0934100

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotationImported, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-PFA-6781823 Formation of TC-NER Pre-Incision Complex

Names & Taxonomyi

Protein namesi
Submitted name:
TFIIH basal transcription factor complex helicase XPD subunitImported (EC:3.6.4.12Imported)
Gene namesi
ORF Names:PF3D7_0934100Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0934100

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ8I2H7
SMRiQ8I2H7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 416Helicase ATP-bindingInterPro annotationAdd BLAST409

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili96 – 116Sequence analysisAdd BLAST21
Coiled coili925 – 945Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000205390
InParanoidiQ8I2H7
KOiK10844
OMAiPSVVRNY
PhylomeDBiQ8I2H7

Family and domain databases

InterProiView protein in InterPro
IPR006555 ATP-dep_Helicase_C
IPR010614 DEAD_2
IPR010643 HBB
IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554 Helicase-like_DEXD_c2
IPR006935 Helicase/UvrB_N
IPR027417 P-loop_NTPase
IPR013020 Rad3/Chl1-like
IPR001945 RAD3/XPD
PANTHERiPTHR11472:SF1 PTHR11472:SF1, 1 hit
PfamiView protein in Pfam
PF06733 DEAD_2, 1 hit
PF06777 HBB, 1 hit
PF13307 Helicase_C_2, 1 hit
PF04851 ResIII, 1 hit
SMARTiView protein in SMART
SM00488 DEXDc2, 1 hit
SM00491 HELICc2, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00604 rad3, 1 hit
PROSITEiView protein in PROSITE
PS51193 HELICASE_ATP_BIND_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8I2H7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVFNLDDVE IFFPYDYIYP EQYAYMKYLK KTLDSEGHCV LEMPTGTGKT
60 70 80 90 100
VAIFSLITSY QYHKKDEGKF IFCTRTVAEM EKSLIELKKV IQYRINVMKQ
110 120 130 140 150
RKVEKLKNEK DDVNDVIKND DVNDVIKNDD VNDVINNDDE EGANNSLDGS
160 170 180 190 200
KENVKEYNKH DDHINNLKEF GENSEILAIG ISARRCMCIN DKVLLKHERE
210 220 230 240 250
KIDEECRKLT ATFIREKKYI NNKIDNEIYH PNVDKISDFI LRNRHHLDIE
260 270 280 290 300
DYFDIYNSRN SLEEYDNIGL CGYYENYKKE FLYDLIKPGV YTIEDLKVLC
310 320 330 340 350
KNYKNKENVN VPICPYFCAK KIIEISKVII LNYQYVIDPK VSKALFSWKD
360 370 380 390 400
MNKNVHLKNK NDIIVFDEAH NIDSVCLEAL SVNIDRNILN KASMNITKLM
410 420 430 440 450
KKIEQSKMLN EQKLKEECNK ILEKIKLQKC NQSLNVTNNV INIDNMKCIN
460 470 480 490 500
HMDNINKTRS DGNVGSYLEK ETNKHHNIEG KPGELFVTNE QEKKKRKVES
510 520 530 540 550
SPVAYFDEDM NLMFSDFFLD ESFGDNEKKK KNHDNNNDIN NDDIKINDDI
560 570 580 590 600
KNNDDINNDD RNNNDDINNN NNDRNNNNGR NNNNDRNNNN EDEDHLNDLC
610 620 630 640 650
YSPLLMEDII KNVVIPGNIR KSEHFLNLMR IVVVYLKKYI NIYDITSEGP
660 670 680 690 700
LSFLYKFEKD TKLDTSFFKY CFDRLKSLLN NLQIVNIEDY SSLNIVCNFC
710 720 730 740 750
TLLGNYFKGF IIICEPYPEA TGIYDPLIQF ACLDSSIAMK TVINKYKSII
760 770 780 790 800
LTSGTITPLE LYPKLLNFKT VLTASFPMSF DRNCVCPLIV TKGSDLIPLS
810 820 830 840 850
SQFSLRNDLS VIKNYGILLV DMCKCIPDGI VAYFPSYIYM EQVISSWYEL
860 870 880 890 900
GVIANILEYK LIFIETKDIV STTIALHNFK KACDLGKGAV FLSICRGKIA
910 920 930 940 950
EGIDFDKHYG KCVILFGIPY QYTLSKILKS RLDFLKETYN IQENEFLTFD
960 970 980 990 1000
AMRQASQCVG RIIRNKKDYG IMIFSDIRYA KHDKKNKLPP WIIKCMDISN
1010 1020 1030 1040 1050
INLTVTTAVD ISKQFLLNMS QEYRETGQTK ISPLMLKNQV KCWTMVKSIL

NMDDFI
Length:1,056
Mass (Da):122,839
Last modified:March 1, 2003 - v1
Checksum:i3FCB46FC2432C26E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844508 Genomic DNA Translation: CAD52016.1
RefSeqiXP_001352206.1, XM_001352170.1

Genome annotation databases

EnsemblProtistsiCAD52016; CAD52016; PF3D7_0934100
GeneDBiPF3D7_0934100.1:pep
GeneIDi813610
KEGGipfa:PF3D7_0934100

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844508 Genomic DNA Translation: CAD52016.1
RefSeqiXP_001352206.1, XM_001352170.1

3D structure databases

ProteinModelPortaliQ8I2H7
SMRiQ8I2H7
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAD52016; CAD52016; PF3D7_0934100
GeneDBiPF3D7_0934100.1:pep
GeneIDi813610
KEGGipfa:PF3D7_0934100

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0934100

Phylogenomic databases

HOGENOMiHOG000205390
InParanoidiQ8I2H7
KOiK10844
OMAiPSVVRNY
PhylomeDBiQ8I2H7

Enzyme and pathway databases

ReactomeiR-PFA-6781823 Formation of TC-NER Pre-Incision Complex

Family and domain databases

InterProiView protein in InterPro
IPR006555 ATP-dep_Helicase_C
IPR010614 DEAD_2
IPR010643 HBB
IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554 Helicase-like_DEXD_c2
IPR006935 Helicase/UvrB_N
IPR027417 P-loop_NTPase
IPR013020 Rad3/Chl1-like
IPR001945 RAD3/XPD
PANTHERiPTHR11472:SF1 PTHR11472:SF1, 1 hit
PfamiView protein in Pfam
PF06733 DEAD_2, 1 hit
PF06777 HBB, 1 hit
PF13307 Helicase_C_2, 1 hit
PF04851 ResIII, 1 hit
SMARTiView protein in SMART
SM00488 DEXDc2, 1 hit
SM00491 HELICc2, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00604 rad3, 1 hit
PROSITEiView protein in PROSITE
PS51193 HELICASE_ATP_BIND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8I2H7_PLAF7
AccessioniPrimary (citable) accession number: Q8I2H7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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