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Entry version 100 (31 Jul 2019)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Lipid/sterol:H+ symporter

Gene

PF3D7_0107500

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Lipid/sterol:H+ symporterImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0107500Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 56HelicalSequence analysisAdd BLAST20
Transmembranei495 – 513HelicalSequence analysisAdd BLAST19
Transmembranei525 – 548HelicalSequence analysisAdd BLAST24
Transmembranei560 – 579HelicalSequence analysisAdd BLAST20
Transmembranei600 – 623HelicalSequence analysisAdd BLAST24
Transmembranei629 – 653HelicalSequence analysisAdd BLAST25
Transmembranei1080 – 1100HelicalSequence analysisAdd BLAST21
Transmembranei1317 – 1335HelicalSequence analysisAdd BLAST19
Transmembranei1342 – 1366HelicalSequence analysisAdd BLAST25
Transmembranei1372 – 1389HelicalSequence analysisAdd BLAST18
Transmembranei1410 – 1432HelicalSequence analysisAdd BLAST23
Transmembranei1438 – 1463HelicalSequence analysisAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8I266

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8I266

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8I266, 5 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini494 – 653SSDInterPro annotationAdd BLAST160

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni183 – 264DisorderedSequence analysisAdd BLAST82
Regioni682 – 704DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili955 – 975Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi213 – 258AcidicSequence analysisAdd BLAST46

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000283815

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8I266

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPKGNIG

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003392 Ptc/Disp
IPR000731 SSD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02460 Patched, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156 SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I266-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFVKNFIHKL KELKQKSLDK FANLLYDYGG YVYDRPCTFI ICSLICCLLL
60 70 80 90 100
TCGFYFKEHE KDIYKLYSIS NSYAYETNET INDFFYKSRR CFILVESNVN
110 120 130 140 150
LLKPKILREL QKFEEGTKDI EVDLSEINEC KTNSELPPEQ SHVAKELYKT
160 170 180 190 200
LIQRSEENLK SGKINGSLFD YSDLDENGKS VLSLAGKENN DDTLIEGDNK
210 220 230 240 250
NDEETSANNN NNEDDNNEDD NNEDDNNEDD NNENDNNNNN EDDNNNDDDD
260 270 280 290 300
DEDNEEEDEE KQKSLREKLY RKIYEMLKKK KENIVLDENN PNVNFTDYKD
310 320 330 340 350
DVFYPYQYIP PMLIKADRCK LQNVFGDKNL NIDLREASDG LKKQITYTLE
360 370 380 390 400
DICEKKYGDC NFSSLFLYYE KGNGYIDYPI KVDNLDFYVN RRTYKEMMFK
410 420 430 440 450
GILGNMVYEK SGSKYIIKSA NAIMTVIPLL NSHTYEPYAL AYEKKLIDYV
460 470 480 490 500
RFYNLDDIIQ DEETNDDNDP FIRFHVFTDR SLEDEVDRIS KIDNLTRLLL
510 520 530 540 550
LIGVLLIFMY ALFNNVTSVL YRSKPLCAVM GIFCGFLGFL SGSGFLYFLG
560 570 580 590 600
VKSVPPAETV PFLVIGVGVD DVFVILNSYS LLFMVKDNKK RIQMCLKDSA
610 620 630 640 650
LAITVTTLTN IIAFLISAIS PFYSICAFSL FTASSLFFGY LMVLTFLLSF
660 670 680 690 700
LCIEAKLEKK KRNIFTGTFH LFRSIFMKSS KKNKKENKEN NIHDDGDNDN
710 720 730 740 750
DEKKKDLSLE VKNNEDDYEN ISIYEWIHNL YLFEESINKK KKNAALVYAS
760 770 780 790 800
NNGMSSNLNN VNEDGFPNPS KIVSMEDVKK RNIKKDDAYI NKEDEEGGGY
810 820 830 840 850
YNKDDNKKKD ILGKKQKKNN NNVTLVSKKG EDNELDVYYE NLDEKTNDKY
860 870 880 890 900
KMNNIKSSKL KYDNDKKDGA IINNRPSSDE EYKEEKDKNK INILNDVFND
910 920 930 940 950
ITIKPNENIL LDRGDVIKSS GYDSSYNDLQ SSSLPNPSSN EVLNKTTMVY
960 970 980 990 1000
NETDLKDNKK EIKSSKKNVK DIKKSDMIHD DTYDIINSNN KNILLSSNEI
1010 1020 1030 1040 1050
NNNSNNTNKF NNNSTELATK DTQQFINGHD KNIYLLSSHD NALFYKYIYE
1060 1070 1080 1090 1100
EPKGNIGKYF RSLVKNYYVP FLSSRFGKTI VYIMFTIIIA MSIYGCTLMK
1110 1120 1130 1140 1150
KGIKYDKAFP VDSYVRRFTT AKIKYFPDFG DFIEVYYFDK HFINKYRGLE
1160 1170 1180 1190 1200
KNTKEAASSF LYSDLTDRQI MNSPKINKNV HWENTNLQEE LINMHNTLES
1210 1220 1230 1240 1250
QEFVTSVANG FTFFLNKNKS SLRKENPQEF YEIFANWLKK DFVGNLFKND
1260 1270 1280 1290 1300
FVFLNGKLVA WRFHYFQKNV DDSEISSKWL KACKQITKLE NHNVQMVCFH
1310 1320 1330 1340 1350
LSSIFNETDE SIIEVTLINL GITILTILVV TAYIIKGFYS CVIIALIIFL
1360 1370 1380 1390 1400
IDLCIFGFMC LCGITMNIIS MVILVLSVGF SIDHTSHIVQ AFSHSMGRTR
1410 1420 1430 1440 1450
DEKMKESLHL MIGPVLHSGL STWFVISTLF FSNKDFTVIF FQTLSLVLFF
1460 1470
SITFSSMFLP VLLSSFGPLH
Length:1,470
Mass (Da):170,301
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D2729E1CD1C399C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844501 Genomic DNA Translation: CAD49035.1

NCBI Reference Sequences

More...
RefSeqi
XP_001351007.1, XM_001350971.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAD49035; CAD49035; PF3D7_0107500

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0107500.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
813212

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0107500

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844501 Genomic DNA Translation: CAD49035.1
RefSeqiXP_001351007.1, XM_001350971.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8I266, 5 interactors

PTM databases

SwissPalmiQ8I266

Proteomic databases

PRIDEiQ8I266

Genome annotation databases

EnsemblProtistsiCAD49035; CAD49035; PF3D7_0107500
GeneDBiPF3D7_0107500.1:pep
GeneIDi813212
KEGGipfa:PF3D7_0107500

Phylogenomic databases

HOGENOMiHOG000283815
InParanoidiQ8I266
OMAiEPKGNIG

Family and domain databases

InterProiView protein in InterPro
IPR003392 Ptc/Disp
IPR000731 SSD
PfamiView protein in Pfam
PF02460 Patched, 2 hits
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I266_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I266
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 31, 2019
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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