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Entry version 144 (16 Oct 2019)
Sequence version 2 (10 May 2005)
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Protein
Submitted name:

ZO-1 (Zonula Occludens tight junctional protein) Ortholog

Gene

zoo-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2028269 Signaling by Hippo

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ZO-1 (Zonula Occludens tight junctional protein) OrthologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:zoo-1Imported
ORF Names:CELE_Y105E8A.26Imported, Y105E8A.26Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
Y105E8A.26a ; CE38437 ; WBGene00013683 ; zoo-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8I103

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8I103

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00013683 Expressed in 4 organ(s), highest expression level in multi-cellular organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8I103 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8I103, 16 interactors

STRING: functional protein association networks

More...
STRINGi
6239.Y105E8A.26a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8I103

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 119PDZInterPro annotationAdd BLAST75
Domaini144 – 222PDZInterPro annotationAdd BLAST79
Domaini325 – 413PDZInterPro annotationAdd BLAST89
Domaini597 – 696Guanylate kinase-likeInterPro annotationAdd BLAST100
Domaini1040 – 1172ZU5InterPro annotationAdd BLAST133

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni243 – 262DisorderedSequence analysisAdd BLAST20
Regioni267 – 294DisorderedSequence analysisAdd BLAST28
Regioni743 – 831DisorderedSequence analysisAdd BLAST89
Regioni868 – 1041DisorderedSequence analysisAdd BLAST174

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 19PolarSequence analysisAdd BLAST19
Compositional biasi783 – 831PolarSequence analysisAdd BLAST49
Compositional biasi877 – 939PolarSequence analysisAdd BLAST63
Compositional biasi952 – 966PolarSequence analysisAdd BLAST15
Compositional biasi983 – 1022PolarSequence analysisAdd BLAST40
Compositional biasi1023 – 1037PolyampholyteSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3580 Eukaryota
ENOG410XQP3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000021695

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8I103

Identification of Orthologs from Complete Genome Data

More...
OMAi
KPVYAQG

Database of Orthologous Groups

More...
OrthoDBi
1175136at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8I103

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000906 ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF00791 ZU5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 3 hits
SM00218 ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 3 hits
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 3 hits
PS51145 ZU5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8I103-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEDPSWYKT SMSSTSSCIE EEHEPVDQDE EEMYNPSGCT WQLLSVSLHR
60 70 80 90 100
AANLGFGIAI SGGRDNPHFT SGDPVVVISD VVPNGPAWGL LQVNDRILSA
110 120 130 140 150
NQVSFENIEY SSAVDIIKNK DHIDMIVKRR VAVPMLEYEQ RTLKFTLSKS
160 170 180 190 200
RKKDDFGIVV GCKFYIKEIR NPKLAEKDPG LKEGDSVLRI NGQSLEGASL
210 220 230 240 250
EEVNKWLERS RDKLCLVIQR DVRRGTSRWP SQNTVYERVG SVAATPRHSP
260 270 280 290 300
SPMLPHMPIT QRNSHEYVNS PRHRSDGSVE RRVSSPANSQ LSNFNGMASS
310 320 330 340 350
QITTQDYDCY TRQPSRSIDA NGVANIMFRK VRGGGGGGGV GGSVGVRVIG
360 370 380 390 400
GNEVGIFVSA VAADSPASLH GVSCGDRILE VNGRNMRGVT RESAVQLLLG
410 420 430 440 450
LDDRVSLRLE HARQDFEHVR ANQLGDNFYI RSHFSREKRD KASPLELSIN
460 470 480 490 500
EGDIFHVTDT LFGGTVGLWQ AARVYSSSEN KGEPVKGVIP NQATAEQIAK
510 520 530 540 550
EWRVYVEAKQ AKSGGSGTLL RRKFESRRTK SLPKNMICDP TELNLPLPAY
560 570 580 590 600
ERVALNTPSF HRPVVLFGPL ADIARHQLLT QFSARFGSPE SDGGVIRLSS
610 620 630 640 650
VDHVIASMKH CVLDISIESV ERLQLAQYAP IVVFLDVDGR SKIREIRKKC
660 670 680 690 700
NAPHLSSRKL AENGNQIKKH HSHLLSATID ATHETGWFDA LRELIGHLQQ
710 720 730 740 750
RRLWMPEFPP NLPLEDVLLF PLPKWDGDVD SLKSEYVDYQ DSLPRKGGEK
760 770 780 790 800
KWDSSPLQTP GDLPSEMREY STMPRPQHHQ LGQDFGGNRN RQSSNSQSTL
810 820 830 840 850
STFVTTASSS NPPRPLLTPT RDESASRTTT PHGYYHVKQL LDDDSLYQDA
860 870 880 890 900
RLANEIANAR LREEAKLREE RVNRQRSELS PSNMQHRLDN TTPSNFDFSN
910 920 930 940 950
VQPSNSNPVP NGRYHPLTPS SMTSSSSGAS RTAGQGQQQT APPPRPPPVN
960 970 980 990 1000
SGNSSPYTQS YIRNKWNNDG AMDARGAENQ TPPVVPARTN GSASPANASI
1010 1020 1030 1040 1050
SLTVSNVPTG SSIASKSPTP RLDENENGQK SEEEEPTVVE ESTALIGSLG
1060 1070 1080 1090 1100
GVIRCEKSNV ELRIPAGAIT EGQEHEIYVK VCREGDSSPI DRSKGETLLS
1110 1120 1130 1140 1150
PLVMCGPQGL KFEKQCELRM PHTGPVTADS DGQWSFSLKT GEGGEWKHME
1160 1170
IEQQQATNAN LDQFLTVPIT HF
Length:1,172
Mass (Da):129,490
Last modified:May 10, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEFC4095E41F10FF4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q56VX4Q56VX4_CAEEL
ZO-1 (Zonula Occludens tight juncti...
zoo-1 CELE_Y105E8A.26, Y105E8A.26
1,133Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H1UBL0H1UBL0_CAEEL
ZO-1 (Zonula Occludens tight juncti...
zoo-1 CELE_Y105E8A.26, Y105E8A.26
1,039Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H1UBK8H1UBK8_CAEEL
ZO-1 (Zonula Occludens tight juncti...
zoo-1 CELE_Y105E8A.26, Y105E8A.26
1,163Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H1UBK9H1UBK9_CAEEL
ZO-1 (Zonula Occludens tight juncti...
zoo-1 CELE_Y105E8A.26, Y105E8A.26
1,131Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAD56252.2

NCBI Reference Sequences

More...
RefSeqi
NP_001021685.1, NM_001026514.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y105E8A.26a.1; Y105E8A.26a.1; WBGene00013683

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
173316

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y105E8A.26

UCSC genome browser

More...
UCSCi
Y105E8A.26b c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAD56252.2
RefSeqiNP_001021685.1, NM_001026514.3

3D structure databases

SMRiQ8I103
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8I103, 16 interactors
STRINGi6239.Y105E8A.26a

Proteomic databases

EPDiQ8I103
PaxDbiQ8I103

Genome annotation databases

EnsemblMetazoaiY105E8A.26a.1; Y105E8A.26a.1; WBGene00013683
GeneIDi173316
KEGGicel:CELE_Y105E8A.26
UCSCiY105E8A.26b c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
173316
WormBaseiY105E8A.26a ; CE38437 ; WBGene00013683 ; zoo-1

Phylogenomic databases

eggNOGiKOG3580 Eukaryota
ENOG410XQP3 LUCA
GeneTreeiENSGT00940000171028
HOGENOMiHOG000021695
InParanoidiQ8I103
OMAiKPVYAQG
OrthoDBi1175136at2759
PhylomeDBiQ8I103

Enzyme and pathway databases

ReactomeiR-CEL-2028269 Signaling by Hippo

Gene expression databases

BgeeiWBGene00013683 Expressed in 4 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiQ8I103 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF00791 ZU5, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 3 hits
SM00218 ZU5, 1 hit
SUPFAMiSSF50156 SSF50156, 3 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 3 hits
PS51145 ZU5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I103_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I103
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: May 10, 2005
Last modified: October 16, 2019
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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