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Entry version 107 (22 Apr 2020)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Stearoyl-CoA desaturase

Gene

PF3D7_0511200

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.19.1 4889

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-PFA-75105 Fatty acyl-CoA biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Stearoyl-CoA desaturaseImported (EC:1.14.19.1Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0511200Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_0511200

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 47HelicalSequence analysisAdd BLAST18
Transmembranei59 – 78HelicalSequence analysisAdd BLAST20
Transmembranei84 – 101HelicalSequence analysisAdd BLAST18
Transmembranei207 – 229HelicalSequence analysisAdd BLAST23
Transmembranei235 – 259HelicalSequence analysisAdd BLAST25
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Transmembranei303 – 322HelicalSequence analysisAdd BLAST20
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei360 – 381HelicalSequence analysisAdd BLAST22
Transmembranei393 – 416HelicalSequence analysisAdd BLAST24
Transmembranei481 – 499HelicalSequence analysisAdd BLAST19
Transmembranei506 – 524HelicalSequence analysisAdd BLAST19
Transmembranei662 – 685HelicalSequence analysisAdd BLAST24
Transmembranei715 – 738HelicalSequence analysisAdd BLAST24
Transmembranei750 – 769HelicalSequence analysisAdd BLAST20
Transmembranei790 – 811HelicalSequence analysisAdd BLAST22
Transmembranei817 – 841HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8I0W9

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8I0W9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8I0W9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili144 – 164Sequence analysisAdd BLAST21
Coiled coili173 – 200Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The histidine box domains are involved in binding the catalytic metal ions.UniRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fatty acid desaturase type 1 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_310265_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8I0W9

KEGG Orthology (KO)

More...
KOi
K00507

Identification of Orthologs from Complete Genome Data

More...
OMAi
VYECKRG

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03505 Delta9-FADS-like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015876 Acyl-CoA_DS

The PANTHER Classification System

More...
PANTHERi
PTHR11351 PTHR11351, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00075 FACDDSATRASE

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I0W9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIEMILSYVY KSLAGVLHTL NKSYLDIKDI GVTYLTYFIF LISCYLLKNY
60 70 80 90 100
FSFKFLNFIR IVKSSIVLII CLISLKYLDL NLTLSINFFY LYNILQLSNF
110 120 130 140 150
LEVSTSQNKK SNNKSKNVEA KVINKYELRN ENEEKNYELI GDTSKHLEKI
160 170 180 190 200
AKKILNNKKK LEENECILKE KEIIDEIERK EKEEEEIMKM KNNLNAKKNK
210 220 230 240 250
DKRKDKINLY GIYVFFLQTF YIYFFYFFWN YIQNLIIIKI FLTLQLVKCL
260 270 280 290 300
ISFVSNFWIN NMNINLFKRM IHILDIVYMF SISLFFTNIL YNISQNTHFL
310 320 330 340 350
RNFAVYSIVF HVYYAYVLFV KYIYTYHKQF RSSLFSFILF FHVFGIIGMI
360 370 380 390 400
KLYYHEYGKS LLIQCVIFYL INGFGITFGA HRLWSHRAFK AGHIVQVLFL
410 420 430 440 450
ILNSFANQGS VIVWAINHRL HHKYSDTKYD PHNIRYGFFY SHVGWLLYQK
460 470 480 490 500
TKYVKEKEKE IYVDDLLQNP YLLLQHKLDP YFNFFFCFII PGIYSYFMYN
510 520 530 540 550
NFWDGFFILG ALRWIITLHA TWSINSASHS FGHRPYNIDI KPTNNIFTSI
560 570 580 590 600
VALGEGCHNY HHVFPYCYAM NENFYILSIN PTKYLINFFY YLGLVWDLKC
610 620 630 640 650
AKNICKEVRL RETLKLEKRN KALSENIKNE IMKKEDTSYV IELMNSFKAL
660 670 680 690 700
CNDYLNISTF MYILYFLRDI VIMITIFLIH ICYCYNKYGN GTMFSTISQK
710 720 730 740 750
FNIENNKYIS ISLSFFFHII LYTLPMGTMF ASLYALVYEC KRELLFKKPL
760 770 780 790 800
FNHFFGSIIS SFILLPYTSE KNRKSVLTAL NEDFVKILKG PIYFDIYSLI
810 820 830 840 850
FTFFSVFYIM TYYIFGYFYF CTFFLGPYIV FNAWLLIYIY LLKNPPFLQM
860 870 880 890 900
DINTKEVDIG VLNYVAFQSL LQWKKNNSIY QSKKRLYKMV FSFINFIHHH
910 920 930 940
LCYTHVVEFI NASIPSYRTK EIYKHFDKTL DQYNFLRNDK FMDVLKEFL
Length:949
Mass (Da):114,073
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB8C77E6A60DA605
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844504 Genomic DNA Translation: CAD51476.1

NCBI Reference Sequences

More...
RefSeqi
XP_001351669.1, XM_001351633.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAD51476; CAD51476; PF3D7_0511200

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0511200.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
812825

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0511200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844504 Genomic DNA Translation: CAD51476.1
RefSeqiXP_001351669.1, XM_001351633.1

3D structure databases

SMRiQ8I0W9
ModBaseiSearch...

PTM databases

SwissPalmiQ8I0W9

Proteomic databases

PRIDEiQ8I0W9

Genome annotation databases

EnsemblProtistsiCAD51476; CAD51476; PF3D7_0511200
GeneDBiPF3D7_0511200.1:pep
GeneIDi812825
KEGGipfa:PF3D7_0511200

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0511200

Phylogenomic databases

HOGENOMiCLU_310265_0_0_1
InParanoidiQ8I0W9
KOiK00507
OMAiVYECKRG

Enzyme and pathway databases

BRENDAi1.14.19.1 4889
ReactomeiR-PFA-75105 Fatty acyl-CoA biosynthesis

Family and domain databases

CDDicd03505 Delta9-FADS-like, 1 hit
InterProiView protein in InterPro
IPR015876 Acyl-CoA_DS
PANTHERiPTHR11351 PTHR11351, 1 hit
PRINTSiPR00075 FACDDSATRASE

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I0W9_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I0W9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 22, 2020
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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