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Entry version 101 (31 Jul 2019)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Merozoite surface protein 1

Gene

PF3D7_0930300

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PLASMO:PFI1475W-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Merozoite surface protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0930300Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_0930300

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1701 – 1719HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500430789720 – 1720Sequence analysisAdd BLAST1701

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8I0U8

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8I0U8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Keywords - Developmental stagei

MerozoiteImported

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8I0U8, 43 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8I0U8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini981 – 1536MSP1_CInterPro annotationAdd BLAST556
Domaini1612 – 1648EGF_MSP1_1InterPro annotationAdd BLAST37
Domaini1655 – 1698EGF_3InterPro annotationAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni63 – 137DisorderedSequence analysisAdd BLAST75
Regioni723 – 775DisorderedSequence analysisAdd BLAST53
Regioni908 – 955DisorderedSequence analysisAdd BLAST48
Regioni1249 – 1278DisorderedSequence analysisAdd BLAST30
Regioni1470 – 1491DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili300 – 327Sequence analysisAdd BLAST28
Coiled coili355 – 375Sequence analysisAdd BLAST21
Coiled coili474 – 519Sequence analysisAdd BLAST46
Coiled coili592 – 619Sequence analysisAdd BLAST28
Coiled coili1058 – 1078Sequence analysisAdd BLAST21
Coiled coili1114 – 1134Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 130PolarSequence analysisAdd BLAST68
Compositional biasi723 – 742PolarSequence analysisAdd BLAST20
Compositional biasi908 – 951PolarSequence analysisAdd BLAST44
Compositional biasi1258 – 1278PolarSequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065832

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8I0U8

KEGG Orthology (KO)

More...
KOi
K13838

Identification of Orthologs from Complete Genome Data

More...
OMAi
EEWRCLL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8I0U8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024731 EGF_dom
IPR010901 MSP1_C
IPR024730 MSP1_EGF_1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12947 EGF_3, 1 hit
PF12946 EGF_MSP1_1, 1 hit
PF07462 MSP1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I0U8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIIFFLCSF LFFIINTQCV THESYQELVK KLEALEDAVL TGYSLFQKEK
60 70 80 90 100
MVLNEEEITT KGASAQSGAS AQSGASAQSG ASAQSGASAQ SGASAQSGTS
110 120 130 140 150
GPSGPSGTSP SSRSNTLPRS NTSSGASPPA DASDSDAKSY ADLKHRVRNY
160 170 180 190 200
LFTIKELKYP ELFDLTNHML TLCDNIHGFK YLIDGYEEIN ELLYKLNFYF
210 220 230 240 250
DLLRAKLNDV CANDYCQIPF NLKIRANELD VLKKLVFGYR KPLDNIKDNV
260 270 280 290 300
GKMEDYIKKN KTTIANINEL IEGSKKTIDQ NKNADNEEGK KKLYQAQYDL
310 320 330 340 350
SIYNKQLEEA HNLISVLEKR IDTLKKNENI KKLLDKINEI KNPPPANSGN
360 370 380 390 400
TPNTLLDKNK KIEEHEEKIK EIAKTIKFNI DSLFTDPLEL EYYLREKNKK
410 420 430 440 450
VDVTPKSQDP TKSVQIPKVP YPNGIVYPLP LTDIHNSLAA DNDKNSYGDL
460 470 480 490 500
MNPHTKEKIN EKIITDNKER KIFINNIKKK IDLEEKNINH TKEQNKKLLE
510 520 530 540 550
DYEKSKKDYE ELLEKFYEMK FNNNFNKDVV DKIFSARYTY NVEKQRYNNK
560 570 580 590 600
FSSSNNSVYN VQKLKKALSY LEDYSLRKGI SEKDFNHYYT LKTGLEADIK
610 620 630 640 650
KLTEEIKSSE NKILEKNFKG LTHSANGSLE VSDIVKLQVQ KVLLIKKIED
660 670 680 690 700
LRKIELFLKN AQLKDSIHVP NIYKPQNKPE PYYLIVLKKE VDKLKEFIPK
710 720 730 740 750
VKDMLKKEQA VLSSITQPLV AASETTEDGG HSTHTLSQSG ETEVTEETEE
760 770 780 790 800
TEETVGHTTT VTITLPPTQP SPPKEVKVVE NSIEHKSNDN SQALTKTVYL
810 820 830 840 850
KKLDEFLTKS YICHKYILVS NSSMDQKLLE VYNLTPEEEN ELKSCDPLDL
860 870 880 890 900
LFNIQNNIPA MYSLYDSMNN DLQHLFFELY QKEMIYYLHK LKEENHIKKL
910 920 930 940 950
LEEQKQITGT SSTSSPGNTT VNTAQSATHS NSQNQQSNAS STNTQNGVAV
960 970 980 990 1000
SSGPAVVEES HDPLTVLSIS NDLKGIVSLL NLGNKTKVPN PLTISTTEME
1010 1020 1030 1040 1050
KFYENILKNN DTYFNDDIKQ FVKSNSKVIT GLTETQKNAL NDEIKKLKDT
1060 1070 1080 1090 1100
LQLSFDLYNK YKLKLDRLFN KKKELGQDKM QIKKLTLLKE QLESKLNSLN
1110 1120 1130 1140 1150
NPHNVLQNFS VFFNKKKEAE IAETENTLEN TKILLKHYKG LVKYYNGESS
1160 1170 1180 1190 1200
PLKTLSEVSI QTEDNYANLE KFRVLSKIDG KLNDNLHLGK KKLSFLSSGL
1210 1220 1230 1240 1250
HHLITELKEV IKNKNYTGNS PSENNKKVNE ALKSYENFLP EAKVTTVVTP
1260 1270 1280 1290 1300
PQPDVTPSPL SVRVSGSSGS TKEETQIPTS GSLLTELQQV VQLQNYDEED
1310 1320 1330 1340 1350
DSLVVLPIFG ESEDNDEYLD QVVTGEAISV TMDNILSGFE NEYDVIYLKP
1360 1370 1380 1390 1400
LAGVYRSLKK QIEKNIFTFN LNLNDILNSR LKKRKYFLDV LESDLMQFKH
1410 1420 1430 1440 1450
ISSNEYIIED SFKLLNSEQK NTLLKSYKYI KESVENDIKF AQEGISYYEK
1460 1470 1480 1490 1500
VLAKYKDDLE SIKKVIKEEK EKFPSSPPTT PPSPAKTDEQ KKESKFLPFL
1510 1520 1530 1540 1550
TNIETLYNNL VNKIDDYLIN LKAKINDCNV EKDEAHVKIT KLSDLKAIDD
1560 1570 1580 1590 1600
KIDLFKNPYD FEAIKKLIND DTKKDMLGKL LSTGLVQNFP NTIISKLIEG
1610 1620 1630 1640 1650
KFQDMLNISQ HQCVKKQCPE NSGCFRHLDE REECKCLLNY KQEGDKCVEN
1660 1670 1680 1690 1700
PNPTCNENNG GCDADATCTE EDSGSSRKKI TCECTKPDSY PLFDGIFCSS
1710 1720
SNFLGISFLL ILMLILYSFI
Length:1,720
Mass (Da):195,726
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i549926C112475DA0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844508 Genomic DNA Translation: CAD51981.1

NCBI Reference Sequences

More...
RefSeqi
XP_001352170.1, XM_001352134.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAD51981; CAD51981; PF3D7_0930300

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0930300.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
813575

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0930300

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844508 Genomic DNA Translation: CAD51981.1
RefSeqiXP_001352170.1, XM_001352134.1

3D structure databases

SMRiQ8I0U8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8I0U8, 43 interactors

PTM databases

SwissPalmiQ8I0U8

Proteomic databases

PRIDEiQ8I0U8

Genome annotation databases

EnsemblProtistsiCAD51981; CAD51981; PF3D7_0930300
GeneDBiPF3D7_0930300.1:pep
GeneIDi813575
KEGGipfa:PF3D7_0930300

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0930300

Phylogenomic databases

HOGENOMiHOG000065832
InParanoidiQ8I0U8
KOiK13838
OMAiEEWRCLL
PhylomeDBiQ8I0U8

Enzyme and pathway databases

BioCyciPLASMO:PFI1475W-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR024731 EGF_dom
IPR010901 MSP1_C
IPR024730 MSP1_EGF_1
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF12946 EGF_MSP1_1, 1 hit
PF07462 MSP1_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I0U8_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I0U8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 31, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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