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Protein
Submitted name:

Heavy neurofilament protein

Gene

NFH

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Heavy neurofilament proteinImported
Gene namesi
Name:NFHImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filamentPROSITE-ProRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ8HZW3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 410IF rodInterPro annotationAdd BLAST317

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili98 – 132Sequence analysisAdd BLAST35
Coiled coili175 – 223Sequence analysisAdd BLAST49
Coiled coili294 – 381Sequence analysisAdd BLAST88
Coiled coili454 – 491Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGME Eukaryota
ENOG410XPTM LUCA
HOGENOMiHOG000230977
HOVERGENiHBG013015
KOiK04574

Family and domain databases

InterProiView protein in InterPro
IPR010790 DUF1388
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR033183 NF-H
PANTHERiPTHR23214 PTHR23214, 2 hits
PfamiView protein in Pfam
PF07142 DUF1388, 12 hits
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8HZW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSFSGADAL LGAPFAPLHG GGSLHYALAR KGGTRSTAGS SSGFHSWART
60 70 80 90 100
SVSSVSASPS RFRGAAATSS TDSLDTLSNG PEGCVVAAAA ARSEKEQLQA
110 120 130 140 150
LNDRFAGYID KVRQLEAHNR SLEGEAAALR QQHAGRAAMG ELYEREVREM
160 170 180 190 200
RGAVLRLGAA RGQLRLEQEH LLEDIAHVRQ RLDDEARQRE EAEAAARALA
210 220 230 240 250
RFAQEAEAAR VELQKKAQAL QEECGYLRRH HQEEVGELLG QIQGCGAAQA
260 270 280 290 300
QAQAEARDAL KCDVTSALRE IRAQLEGHAV QSTLQSEEWF RVRLDRLSEA
310 320 330 340 350
AKVNTDAMRS AQEEITEYRR QLQARTTELE ALKGTKDSLE RQRSELEDRH
360 370 380 390 400
QADIASYQEA IQQLDTELRN TKWEMAAQLR EYQDLLNVKM ALDIEIAAYR
410 420 430 440 450
KLLEGEECRI GFGPSPFSLP EGLPKIPSTS THIKVKSEEK IKVVEKSEKE
460 470 480 490 500
TVILEEQTEE IQVTEEVTEE EEKEAKEEKG EEEEAEEGEE ETKSPPAEEA
510 520 530 540 550
ASPEKEEAKS PEKAKSPMKE EAKSPAEAKS PVKEEAKSPA EVKSPEKAKS
560 570 580 590 600
PMKEEAKSPT EVKSPEKAKS PAKEEAKSPV EAKSPEKAKS PVKEEAKSPE
610 620 630 640 650
KAKSPVKEEA KSPEKAKSPV KEEAKSPEKA KSPEKAKSPV KEEAKSPEKA
660 670 680 690 700
KSPVKEEAKS PEKAKSPVKE EAKSPEKTKS PVKEEAKSPE KAKSPEKAKS
710 720 730 740 750
PVKEEAKSPE KAKSPVKEEA KSPEKAKSPV KEEAKSPEKA KSPVKEEAKS
760 770 780 790 800
PEKAKSPVKE EAKSPEKPKS PVKEEAKSPE KAKSPEKAKS PVKEEAKSPE
810 820 830 840 850
KAKSPVKEEA KSPEKAKSPV KEEAKSPEKA KSPVKEEAKS PEKAKSPVKE
860 870 880 890 900
EAKSPEKAKS PEKAKSPVKE EAKSPEKAKS PEKAKSPVKE EAKSPEKAKS
910 920 930 940 950
PEKVKSPVKE ETKAPEKEVT KKEEAKSPIK EEEKPQEVKV KEPAKKAEEE
960 970 980 990 1000
KAPATPKTEE KKDSKKDEVP KKEAPKPEVP EKKEPAVEKP KESKVEAKKE
1010 1020 1030 1040 1050
TEDKKKAVTP EKEVPAKVKE EAKPKEKAEV AKKEQDDAKA KEPSKAAEKE
1060 1070 1080 1090 1100
PEKPKKEGTP AAPEKKDVKE EKTPEAKKSE EKPKAEAPAK EEPSKEAPTP
1110 1120 1130
GKAKTEKAEK SSSTDQKDSR PAEKATEDKA SKGEK
Length:1,135
Mass (Da):124,479
Last modified:March 1, 2003 - v1
Checksum:iFE154F8A8D85BC47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346625 mRNA Translation: AAN40837.1
RefSeqiNP_001003352.1, NM_001003352.1
UniGeneiCfa.1268

Genome annotation databases

GeneIDi442940
KEGGicfa:442940

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346625 mRNA Translation: AAN40837.1
RefSeqiNP_001003352.1, NM_001003352.1
UniGeneiCfa.1268

3D structure databases

ProteinModelPortaliQ8HZW3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi442940
KEGGicfa:442940

Organism-specific databases

CTDi4744

Phylogenomic databases

eggNOGiENOG410IGME Eukaryota
ENOG410XPTM LUCA
HOGENOMiHOG000230977
HOVERGENiHBG013015
KOiK04574

Family and domain databases

InterProiView protein in InterPro
IPR010790 DUF1388
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR033183 NF-H
PANTHERiPTHR23214 PTHR23214, 2 hits
PfamiView protein in Pfam
PF07142 DUF1388, 12 hits
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8HZW3_CANLF
AccessioniPrimary (citable) accession number: Q8HZW3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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