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Entry version 106 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Transferrin receptor protein 1

Gene

TFRC

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity).

Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).

Positively regulates T and B cell proliferation through iron uptake (By similarity).

Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity).

When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity).

When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M28.972

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transferrin receptor protein 1
Short name:
TR
Short name:
TfR
Short name:
TfR1
Short name:
Trfr
Alternative name(s):
CD_antigen: CD71
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFRC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13
  • UP000008227 Componenti: Chromosome 13

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:93925, TFRC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 68CytoplasmicSequence analysisAdd BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 768ExtracellularSequence analysisAdd BLAST679

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002376161 – 768Transferrin receptor protein 1Add BLAST768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei20PhosphotyrosineBy similarity1
Modified residuei21PhosphothreonineBy similarity1
Modified residuei24PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi70S-palmitoyl cysteineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi92InterchainBy similarity
Disulfide bondi101InterchainBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi259N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi325N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi730N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi735N-linked (GlcNAc...) asparagineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation (By similarity). Stearoylation does not affect iron uptake (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8HZV3

PeptideAtlas

More...
PeptideAtlasi
Q8HZV3

PRoteomics IDEntifications database

More...
PRIDEi
Q8HZV3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8HZV3, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit.

Interacts with SH3BP4 (By similarity).

Interacts with SH3BP3.

Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000029501

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8HZV3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini231 – 321PAAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 70Mediates interaction with SH3BP4By similarityAdd BLAST70
Regioni577 – 768Ligand-bindingBy similarityAdd BLAST192

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi20 – 23Endocytosis signal4
Motifi61 – 64Stop-transfer sequence4
Motifi654 – 656Cell attachment siteSequence analysis3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M28 family. M28B subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2195, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234598

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8HZV3

Database of Orthologous Groups

More...
OrthoDBi
804230at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02128, PA_TfR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.930.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003137, PA_domain
IPR007484, Peptidase_M28
IPR039373, Peptidase_M28B
IPR029513, TfR
IPR007365, TFR-like_dimer_dom
IPR036757, TFR-like_dimer_dom_sf
IPR037324, TfR1/2_PA

The PANTHER Classification System

More...
PANTHERi
PTHR10404, PTHR10404, 1 hit
PTHR10404:SF26, PTHR10404:SF26, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02225, PA, 1 hit
PF04389, Peptidase_M28, 1 hit
PF04253, TFR_dimer, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47672, SSF47672, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8HZV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDQARSAFS SLFGGEPLSY TRFSLARQVD GDNSHVEMKL AADEEENVDS
60 70 80 90 100
NTRSNHIGVA KPKRLNGYVC YGIIAVITFF LIGFMIGYLA YCKRVESKTD
110 120 130 140 150
CKTLVPTEPS ETEETETFEA ENFPQTPRLF WADLKILLSK GLDTTDFTRT
160 170 180 190 200
IKMLNEDYAP REAGSQKDES LGFFIENQFR EFKLSKVWHD EHFVKIQVKG
210 220 230 240 250
SNAENSVTLV NTDSNSLVYP VESPEGYVAY SKATTVTGKL IFANFGTKKD
260 270 280 290 300
FEDLKMPVNG SLVIVRAGKI TFAEKVANAQ SLDAIGVLIY MDRANFPIIN
310 320 330 340 350
ADVPVFGHAH LGTGDPYTPG FPSFNHTQFP PSQSSGLPNI PVQTISRAGA
360 370 380 390 400
EKLFGNMEQD CPLTWRTDFP CKLVSSPSKN VKLTVNNVLK EIKILNIFGV
410 420 430 440 450
IKGFEEPDRY VIVGAQRDAW GPGAAKSSVG TSLLLNLAQI LSDMVIKGQF
460 470 480 490 500
KPSRSIVFAS WSAGDFGAIG ATEWLEGYLS SLHLKAFTYI NLDKAVLGTS
510 520 530 540 550
NFKVSASPLL YSLIEKMMQD VKNPVTGQSL YRDSNWINKV EKLSFDDAAF
560 570 580 590 600
PFLAYSGIPA VSFCFCEDTD YPYLGTTMDT YDVLSKRVPQ LNRMARAAAE
610 620 630 640 650
VAGHLVIKLT IDFELNLNYE MYNDKILSFV REMNQFRVDI REMGLSLQWL
660 670 680 690 700
YSARGDFFRA TSRLTSDYRN VETRDKFVMR EINDRIMKVE YHFLSPYVSP
710 720 730 740 750
RESPFRHIFW GSGSHTLSAL VEHLKLRQKN SSAFNQTLLK NQLALATWTI
760
QGAANALSGD IWDIDNEF
Length:768
Mass (Da):86,122
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55B15CEFA2F4D1CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5S6GXI4A0A5S6GXI4_PIG
Transferrin receptor protein 1
TFRC
794Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF416763 mRNA Translation: AAN09749.1

NCBI Reference Sequences

More...
RefSeqi
NP_999166.1, NM_214001.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000012960; ENSSSCP00000012619; ENSSSCG00000011848
ENSSSCT00005038577; ENSSSCP00005023673; ENSSSCG00005024344
ENSSSCT00005038600; ENSSSCP00005023689; ENSSSCG00005024344
ENSSSCT00005038626; ENSSSCP00005023711; ENSSSCG00005024344
ENSSSCT00005038807; ENSSSCP00005023845; ENSSSCG00005024344
ENSSSCT00005038830; ENSSSCP00005023862; ENSSSCG00005024344
ENSSSCT00005038866; ENSSSCP00005023875; ENSSSCG00005024344
ENSSSCT00015094782; ENSSSCP00015038877; ENSSSCG00015069917
ENSSSCT00025040290; ENSSSCP00025017146; ENSSSCG00025029620
ENSSSCT00040042676; ENSSSCP00040017879; ENSSSCG00040031412
ENSSSCT00045017888; ENSSSCP00045012318; ENSSSCG00045010359
ENSSSCT00050086561; ENSSSCP00050037146; ENSSSCG00050063573
ENSSSCT00055011713; ENSSSCP00055009275; ENSSSCG00055005971
ENSSSCT00065003468; ENSSSCP00065001260; ENSSSCG00065002628
ENSSSCT00070023963; ENSSSCP00070019815; ENSSSCG00070011774
ENSSSCT00070023968; ENSSSCP00070019819; ENSSSCG00070011774
ENSSSCT00070023975; ENSSSCP00070019827; ENSSSCG00070011774
ENSSSCT00070023978; ENSSSCP00070019830; ENSSSCG00070011774
ENSSSCT00070023989; ENSSSCP00070019840; ENSSSCG00070011774
ENSSSCT00070024000; ENSSSCP00070019851; ENSSSCG00070011774
ENSSSCT00070024010; ENSSSCP00070019860; ENSSSCG00070011774

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397062

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:397062

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416763 mRNA Translation: AAN09749.1
RefSeqiNP_999166.1, NM_214001.1

3D structure databases

SMRiQ8HZV3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000029501

Protein family/group databases

MEROPSiM28.972

Proteomic databases

PaxDbiQ8HZV3
PeptideAtlasiQ8HZV3
PRIDEiQ8HZV3

Genome annotation databases

EnsembliENSSSCT00000012960; ENSSSCP00000012619; ENSSSCG00000011848
ENSSSCT00005038577; ENSSSCP00005023673; ENSSSCG00005024344
ENSSSCT00005038600; ENSSSCP00005023689; ENSSSCG00005024344
ENSSSCT00005038626; ENSSSCP00005023711; ENSSSCG00005024344
ENSSSCT00005038807; ENSSSCP00005023845; ENSSSCG00005024344
ENSSSCT00005038830; ENSSSCP00005023862; ENSSSCG00005024344
ENSSSCT00005038866; ENSSSCP00005023875; ENSSSCG00005024344
ENSSSCT00015094782; ENSSSCP00015038877; ENSSSCG00015069917
ENSSSCT00025040290; ENSSSCP00025017146; ENSSSCG00025029620
ENSSSCT00040042676; ENSSSCP00040017879; ENSSSCG00040031412
ENSSSCT00045017888; ENSSSCP00045012318; ENSSSCG00045010359
ENSSSCT00050086561; ENSSSCP00050037146; ENSSSCG00050063573
ENSSSCT00055011713; ENSSSCP00055009275; ENSSSCG00055005971
ENSSSCT00065003468; ENSSSCP00065001260; ENSSSCG00065002628
ENSSSCT00070023963; ENSSSCP00070019815; ENSSSCG00070011774
ENSSSCT00070023968; ENSSSCP00070019819; ENSSSCG00070011774
ENSSSCT00070023975; ENSSSCP00070019827; ENSSSCG00070011774
ENSSSCT00070023978; ENSSSCP00070019830; ENSSSCG00070011774
ENSSSCT00070023989; ENSSSCP00070019840; ENSSSCG00070011774
ENSSSCT00070024000; ENSSSCP00070019851; ENSSSCG00070011774
ENSSSCT00070024010; ENSSSCP00070019860; ENSSSCG00070011774
GeneIDi397062
KEGGissc:397062

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7037
VGNCiVGNC:93925, TFRC

Phylogenomic databases

eggNOGiKOG2195, Eukaryota
GeneTreeiENSGT01030000234598
InParanoidiQ8HZV3
OrthoDBi804230at2759

Gene expression databases

ExpressionAtlasiQ8HZV3, baseline and differential

Family and domain databases

CDDicd02128, PA_TfR, 1 hit
Gene3Di1.20.930.40, 1 hit
InterProiView protein in InterPro
IPR003137, PA_domain
IPR007484, Peptidase_M28
IPR039373, Peptidase_M28B
IPR029513, TfR
IPR007365, TFR-like_dimer_dom
IPR036757, TFR-like_dimer_dom_sf
IPR037324, TfR1/2_PA
PANTHERiPTHR10404, PTHR10404, 1 hit
PTHR10404:SF26, PTHR10404:SF26, 1 hit
PfamiView protein in Pfam
PF02225, PA, 1 hit
PF04389, Peptidase_M28, 1 hit
PF04253, TFR_dimer, 1 hit
SUPFAMiSSF47672, SSF47672, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFR1_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8HZV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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