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Protein
Submitted name:

Multidrug resistance p-glycoprotein

Gene
N/A
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi430 – 437ATPPROSITE-ProRule annotation8
Nucleotide bindingi1073 – 1080ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Multidrug resistance p-glycoproteinImported
Submitted name:
Multidrug resistance protein 1Imported
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)Imported
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 72HelicalSequence analysisAdd BLAST24
Transmembranei118 – 142HelicalSequence analysisAdd BLAST25
Transmembranei193 – 211HelicalSequence analysisAdd BLAST19
Transmembranei217 – 236HelicalSequence analysisAdd BLAST20
Transmembranei296 – 319HelicalSequence analysisAdd BLAST24
Transmembranei711 – 736HelicalSequence analysisAdd BLAST26
Transmembranei756 – 780HelicalSequence analysisAdd BLAST25
Transmembranei862 – 882HelicalSequence analysisAdd BLAST21
Transmembranei938 – 957HelicalSequence analysisAdd BLAST20
Transmembranei977 – 998HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ8HZQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 360ABC transmembrane type-1InterPro annotationAdd BLAST309
Domaini395 – 631ABC transporterInterPro annotationAdd BLAST237
Domaini715 – 1003ABC transmembrane type-1InterPro annotationAdd BLAST289
Domaini1038 – 1276ABC transporterInterPro annotationAdd BLAST239

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili270 – 290Sequence analysisAdd BLAST21
Coiled coili637 – 657Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00530000062896
HOVERGENiHBG080809
KOiK05658

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030258 MDR1
IPR027417 P-loop_NTPase
PANTHERiPTHR24221:SF251 PTHR24221:SF251, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 3 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q8HZQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLEGDRNGG AEKKNFFKLN NKSKKDKKER KPTVSVFSMF RYSNWLDKLY
60 70 80 90 100
MVVGTLAAII HGAGLPLMML VFGDMTDTFA NAGNLGDLGA LLFNNTNSSN
110 120 130 140 150
ITDTVPVMNL EEDMTRYAYY YSGIGAGVLV AAYIQVSFWC LAAGRQIHKI
160 170 180 190 200
RKQFFHAIMR QEIGWFDVHD VGELNTRLTD DVSKINEGIG DKIGMFFQSM
210 220 230 240 250
ATFFTGFIVG FTRGWKLTLV ILAISPVLGL SAAVWAKILS SFTDKELLAY
260 270 280 290 300
AKAGAVAEEV LAAIRTVIAF GGQKKELERY NKNLEEAKRI GIKKAITANI
310 320 330 340 350
SIGAAFLLIY ASYALAFWYG TTLVLSKEYS IGQVLTVFFS VLIGAFSVGQ
360 370 380 390 400
ASPSIEAFAN ARGAAFEIFK IIDNKPSIDS YSKSGHKPDN IKGNLEFRNV
410 420 430 440 450
HFSYPSRKEV KILKGLNLKV QSGQTVALVG NSGCGKSTTV QLMQRLYDPT
460 470 480 490 500
EGMVSVDGQD IRTINVRFLR EIIGVVSQEP VLFATTIAEN IRYGREDVTM
510 520 530 540 550
DEIEKAVKEA NAYDFIMKLP QKFDTLVGER GAQLSGGQKQ RIAIARALVR
560 570 580 590 600
NPKILLLDEA TSALDTESEA VVQVALDKAR KGRTTIVIAH RLSTVRNADV
610 620 630 640 650
IAGFDDGVIV EKGNHDELMK EKGIYFKLVT MQTAGNEIEL ENAADESKSE
660 670 680 690 700
IDTLEMSSHD SGSSLIRKRS TRRSVRGSQG QDRKLSTKEA LDESIPPVSF
710 720 730 740 750
WRIMKLNLTE WPYFVVGVFC AIINGGLQPA FAVIFSKIIG IFTRNDDAET
760 770 780 790 800
KRQNSNLFSL LFLVLGIVSF ITFFLQGFTF GKAGEILTKR LRYMVFRSML
810 820 830 840 850
RQDVSWFDDP KNTTGALTTR LANDAAQVKG AIGSRLAIIT QNIANLGTGI
860 870 880 890 900
IISLIYGWQL TLLLLAIVPI IAIAGVVEMK MLSGQALKDK KELEGAGKIA
910 920 930 940 950
TEAIENFRTV VSLTQEQKFE HMYDQSLQVP YRNSLRKAHI FGITFSFTQA
960 970 980 990 1000
MMYFSYAGCF RFGAYLVAHS LMSFEDVLLV FSAVVFGAMA VGQVSSFAPD
1010 1020 1030 1040 1050
YAKAKVSAAH IIMIIEKTPL IDSYSTEGLK PNTLEGNVTF NEVVFNYPTR
1060 1070 1080 1090 1100
LDIPVLQGLS LEVKKGQTLA LVGSSGCGKS TVVQLLERFY DPLAGKVLLD
1110 1120 1130 1140 1150
GKEIKQLNVQ WLRAHLGIVS QEPILFDCSI SENIAYGDNS RVVSQEEIVR
1160 1170 1180 1190 1200
AAKEANIHAF IESLPNKYST RVGDKGTQLS GGQKQRIAIA RALVRQPHIL
1210 1220 1230 1240 1250
LLDEATSALD TESEKVVQEA LDKAREGRTC IVIAHRLSTI QNADLIVVFQ
1260 1270 1280
NGRVKEHGTH QQLLAQKGIY FSMVSVQAGA KRQ
Length:1,283
Mass (Da):141,552
Last modified:October 1, 2003 - v2
Checksum:iA04AFE510665566F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01047369 Genomic DNA No translation available.
AQIA01047370 Genomic DNA No translation available.
AQIA01047371 Genomic DNA No translation available.
AQIA01047372 Genomic DNA No translation available.
AQIA01047373 Genomic DNA No translation available.
AQIA01047374 Genomic DNA No translation available.
AF537134 mRNA Translation: AAN07780.2
RefSeqiNP_001274251.1, NM_001287322.1
XP_005550376.1, XM_005550319.2
UniGeneiMfa.6258

Genome annotation databases

EnsembliENSMFAT00000013565; ENSMFAP00000039303; ENSMFAG00000038890
GeneIDi102145631
KEGGimcf:102145631

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIA01047369 Genomic DNA No translation available.
AQIA01047370 Genomic DNA No translation available.
AQIA01047371 Genomic DNA No translation available.
AQIA01047372 Genomic DNA No translation available.
AQIA01047373 Genomic DNA No translation available.
AQIA01047374 Genomic DNA No translation available.
AF537134 mRNA Translation: AAN07780.2
RefSeqiNP_001274251.1, NM_001287322.1
XP_005550376.1, XM_005550319.2
UniGeneiMfa.6258

3D structure databases

ProteinModelPortaliQ8HZQ6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMFAT00000013565; ENSMFAP00000039303; ENSMFAG00000038890
GeneIDi102145631
KEGGimcf:102145631

Organism-specific databases

CTDi5243

Phylogenomic databases

GeneTreeiENSGT00530000062896
HOVERGENiHBG080809
KOiK05658

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030258 MDR1
IPR027417 P-loop_NTPase
PANTHERiPTHR24221:SF251 PTHR24221:SF251, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 3 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ8HZQ6_MACFA
AccessioniPrimary (citable) accession number: Q8HZQ6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: October 1, 2003
Last modified: July 18, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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