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Entry version 110 (02 Dec 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Dual oxidase 1

Gene

DUOX1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: thyroid hormone biosynthesis

This protein is involved in the pathway thyroid hormone biosynthesis, which is part of Hormone biosynthesis.
View all proteins of this organism that are known to be involved in the pathway thyroid hormone biosynthesis and in Hormone biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi828 – 8391PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi864 – 8752PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide, Thyroid hormones biosynthesis
LigandCalcium, FAD, Flavoprotein, Metal-binding, NADP

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00194

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
3348, SscDuOx01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual oxidase 1 (EC:1.11.1.-, EC:1.6.3.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DUOX1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced
  • UP000008227 Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 596ExtracellularSequence analysisAdd BLAST575
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei597 – 617HelicalSequence analysisAdd BLAST21
Topological domaini618 – 1046CytoplasmicSequence analysisAdd BLAST429
Transmembranei1047 – 1067HelicalSequence analysisAdd BLAST21
Topological domaini1068 – 1082ExtracellularSequence analysisAdd BLAST15
Transmembranei1083 – 1103HelicalSequence analysisAdd BLAST21
Topological domaini1104 – 1138CytoplasmicSequence analysisAdd BLAST35
Transmembranei1139 – 1159HelicalSequence analysisAdd BLAST21
Topological domaini1160 – 1190ExtracellularSequence analysisAdd BLAST31
Transmembranei1191 – 1211HelicalSequence analysisAdd BLAST21
Topological domaini1212 – 1228CytoplasmicSequence analysisAdd BLAST17
Transmembranei1229 – 1249HelicalSequence analysisAdd BLAST21
Topological domaini1250ExtracellularSequence analysis1
Transmembranei1251 – 1271HelicalSequence analysisAdd BLAST21
Topological domaini1272 – 1553CytoplasmicSequence analysisAdd BLAST282

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022334522 – 1553Dual oxidase 1Add BLAST1532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8HZK3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in thyroid.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TXNDC11, TPO and CYBA.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000005035

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini815 – 850EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini851 – 886EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini895 – 930EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini1089 – 1271Ferric oxidoreductaseAdd BLAST183
Domaini1272 – 1378FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 593Peroxidase-like; mediates peroxidase activityBy similarityAdd BLAST568
Regioni956 – 1250Interaction with TXNDC11By similarityAdd BLAST295

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the peroxidase family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0039, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8HZK3

Database of Orthologous Groups

More...
OrthoDBi
27424at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09820, dual_peroxidase_like, 1 hit
cd00051, EFh, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.640.10, 1 hit
3.40.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029595, DUOX1/Duox
IPR034821, DUOX_peroxidase
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR017938, Riboflavin_synthase-like_b-brl

The PANTHER Classification System

More...
PANTHERi
PTHR11972:SF75, PTHR11972:SF75, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03098, An_peroxidase, 1 hit
PF00036, EF-hand_1, 2 hits
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00457, ANPEROXIDASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF48113, SSF48113, 1 hit
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits
PS51384, FAD_FR, 1 hit
PS50292, PEROXIDASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HZK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFRLALAWT LLVGPWMPMG ARNSISWEVQ RFDGWYNNLM EHKWGSKGSR
60 70 80 90 100
LQRLVPASYA DGVYQPLGEP HLPNPRDLSN TAMRGPAGQA SLRNRTVLGV
110 120 130 140 150
FFGYHVLSDL VSIEKPGCPA EFLNIHIPPG DPVFDPHKSG DVVLPFQRSR
160 170 180 190 200
WDPNTGQSPS NPRDLTNEVT GWLDGSAIYG SSHSWSDELR SFSGGQLASG
210 220 230 240 250
PDPAFPRQAQ DPLFMWTPPD PATGQRGPQG LYAFGAEQGN REPFLQALGL
260 270 280 290 300
LWFRYHNLCA QKLAREHPLW GDEELFQHAR KRVIATYQSI TMYEWLPSFL
310 320 330 340 350
RKMPQEYTGY RPFLDPSISP EFLAASEQFF STMVPPGVYM RNASCHFQGV
360 370 380 390 400
INRNSSVSRA LRVCNSYWSR EHPNLQRAED VDALLLGMAS QIAEREDHMV
410 420 430 440 450
VEDVQDFWPG PLKFSRTDHL ASCLQRGRDL GLPSYTKARA RLGLPPVTRW
460 470 480 490 500
QDINPALSRS DGIVLEATAA LYNQDLSRLE LLPGGLLESY GDPGPLFSTI
510 520 530 540 550
VLDQFVRLRD GDRYWFENTK NGLFSEKEIA EIRNTSLRDV LVAVTNMTPG
560 570 580 590 600
ALQPNVFFWH AGDPCPQPRQ LSTKDLPACA PLIMRDYFKG SGFGFGVTIG
610 620 630 640 650
TLCCFPLVSL LSAWIVAQLR RRNFKRLQVQ NRQSIMCEKL VGGMKALEWQ
660 670 680 690 700
GRKEPCRPVL VHLQSGQIHV MDGRLSVLRT IQLRPPQQVN LILSSNHGRR
710 720 730 740 750
TLLLKIPKEY DLVLMFDLEE ERQVMVENLQ SALKESGLSF QEWELREQEL
760 770 780 790 800
MRAAVTREQR SHLLETFFRH LFSQVLDIDQ ADAGALPLDS SQKVREALTC
810 820 830 840 850
ELSRAEFAES LGLKPQDMFV ESMFSLADKD GNGYLSFREF LDILVVFMKG
860 870 880 890 900
SPEEKSRLMF RMYDFDGNGL ISKDEFIRML RSFIEISNNC LSKAQLTEVV
910 920 930 940 950
ESMFREAGFQ DKQELTWEDF HFMLRDHDSE LRFTQLCVKG VEVPEVIKDL
960 970 980 990 1000
CRRASYISQE KLCPSPRVSA HCPRSNVDVE VELTPWKLQC PTDTDPPQEI
1010 1020 1030 1040 1050
RRRFGKKVTS FQPLLFTEAH REKFQRSRRH QTVQQFKRFV ENYRRHIGCL
1060 1070 1080 1090 1100
AVFYTIAGGL FLERAYYYAF AAHHMGITDT TRVGIILSRG TAASISFMFS
1110 1120 1130 1140 1150
YILLTMCRNL ITFLRETFLN RYVPFDAAVD FHRLIASTAI ILTVLHSAGH
1160 1170 1180 1190 1200
VVNVYLFSIS PLSVLSCLFP GLFHDNGSEF PQKYYWWFFQ TVPGLTGVML
1210 1220 1230 1240 1250
LLILAIMYVF ASHHFRRCSF RGFWLTHHLY ILLYMLLIIH GSFALIQLPR
1260 1270 1280 1290 1300
FHIFFLVPAL IYVGDKLVSL SRKKVEISVV KAELLPSGVT HLQFQRPQGF
1310 1320 1330 1340 1350
EYKSGQWVRI ACLALGTTEY HPFTLTSAPH EDTLSLHIRA AGPWTTRLRE
1360 1370 1380 1390 1400
IYSPPTDDNC AKYPKLYLDG PFGEGHQEWH KFEVSVLVGG GIGVTPFASI
1410 1420 1430 1440 1450
LKDLVFKSSV SCQVFCKKIY FIWVTRTQRQ FEWLADIIRE VEENDHRDLV
1460 1470 1480 1490 1500
SVHIYITQLA EKFDLRTTML YICERHFQKV LNRSLFTGLR SITHFGRPPF
1510 1520 1530 1540 1550
EPFFNSLQEV HPQVRKIGVF SCGPPGMTKN VEKACQLINR QDRTHFSHHY

ENF
Length:1,553
Mass (Da):177,861
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F9364322977B710
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF547266 mRNA Translation: AAN39338.1

NCBI Reference Sequences

More...
RefSeqi
NP_999261.1, NM_214096.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00015061098; ENSSSCP00015024547; ENSSSCG00015044714
ENSSSCT00015061238; ENSSSCP00015024609; ENSSSCG00015044714
ENSSSCT00030100495; ENSSSCP00030046333; ENSSSCG00030071685
ENSSSCT00035042519; ENSSSCP00035017004; ENSSSCG00035032081
ENSSSCT00040084544; ENSSSCP00040036891; ENSSSCG00040061821
ENSSSCT00045002873; ENSSSCP00045001810; ENSSSCG00045001783
ENSSSCT00050107780; ENSSSCP00050047723; ENSSSCG00050078157
ENSSSCT00055024871; ENSSSCP00055019747; ENSSSCG00055012477
ENSSSCT00060054640; ENSSSCP00060023303; ENSSSCG00060040313

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397177

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:397177

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF547266 mRNA Translation: AAN39338.1
RefSeqiNP_999261.1, NM_214096.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005035

Protein family/group databases

PeroxiBasei3348, SscDuOx01

Proteomic databases

PaxDbiQ8HZK3

Genome annotation databases

EnsembliENSSSCT00015061098; ENSSSCP00015024547; ENSSSCG00015044714
ENSSSCT00015061238; ENSSSCP00015024609; ENSSSCG00015044714
ENSSSCT00030100495; ENSSSCP00030046333; ENSSSCG00030071685
ENSSSCT00035042519; ENSSSCP00035017004; ENSSSCG00035032081
ENSSSCT00040084544; ENSSSCP00040036891; ENSSSCG00040061821
ENSSSCT00045002873; ENSSSCP00045001810; ENSSSCG00045001783
ENSSSCT00050107780; ENSSSCP00050047723; ENSSSCG00050078157
ENSSSCT00055024871; ENSSSCP00055019747; ENSSSCG00055012477
ENSSSCT00060054640; ENSSSCP00060023303; ENSSSCG00060040313
GeneIDi397177
KEGGissc:397177

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
53905

Phylogenomic databases

eggNOGiKOG0039, Eukaryota
InParanoidiQ8HZK3
OrthoDBi27424at2759

Enzyme and pathway databases

UniPathwayiUPA00194

Family and domain databases

CDDicd09820, dual_peroxidase_like, 1 hit
cd00051, EFh, 2 hits
Gene3Di1.10.640.10, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR029595, DUOX1/Duox
IPR034821, DUOX_peroxidase
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR017938, Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF75, PTHR11972:SF75, 1 hit
PfamiView protein in Pfam
PF03098, An_peroxidase, 1 hit
PF00036, EF-hand_1, 2 hits
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit
PRINTSiPR00457, ANPEROXIDASE
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SUPFAMiSSF47473, SSF47473, 1 hit
SSF48113, SSF48113, 1 hit
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits
PS51384, FAD_FR, 1 hit
PS50292, PEROXIDASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDUOX1_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8HZK3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 1, 2003
Last modified: December 2, 2020
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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