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UniProtKB - Q8HZ70 (FMO2_PANTR)
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 2
Gene
FMO2
Organism
Pan troglodytes (Chimpanzee)
Status
Functioni
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.
Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation.
By similarityCofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 32 | FADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 9 – 13 | FADBy similarity | 5 | |
Nucleotide bindingi | 40 – 41 | FADBy similarity | 2 | |
Nucleotide bindingi | 60 – 61 | NADPBy similarity | 2 | |
Nucleotide bindingi | 61 – 62 | FADBy similarity | 2 | |
Nucleotide bindingi | 195 – 198 | NADPBy similarity | 4 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
- monooxygenase activity Source: GO_Central
- N,N-dimethylaniline monooxygenase activity Source: UniProtKB-EC
- NADP binding Source: InterPro
GO - Biological processi
- NADPH oxidation Source: UniProtKB
- organic acid metabolic process Source: Ensembl
- oxygen metabolic process Source: Ensembl
- toxin metabolic process Source: Ensembl
- xenobiotic metabolic process Source: Ensembl
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | FAD, Flavoprotein, Magnesium, NADP |
Names & Taxonomyi
Protein namesi | Recommended name: Dimethylaniline monooxygenase [N-oxide-forming] 2By similarity (EC:1.14.13.-By similarity)Alternative name(s): Dimethylaniline oxidase 2 FMO 1B1 Pulmonary flavin-containing monooxygenase 2 Short name: FMO 2 |
Gene namesi | Name:FMO2By similarity |
Organismi | Pan troglodytes (Chimpanzee) |
Taxonomic identifieri | 9598 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:543, FMO2 |
Subcellular locationi
Endoplasmic reticulum
- Microsome membrane By similarity; Single-pass membrane protein By similarity
- Endoplasmic reticulum membrane By similarity; Single-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 510 – 530 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000147649 | 2 – 535 | Dimethylaniline monooxygenase [N-oxide-forming] 2Add BLAST | 534 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Cross-linki | 492 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity |
Keywords - PTMi
Acetylation, Isopeptide bond, Ubl conjugationProteomic databases
PaxDbi | Q8HZ70 |
Expressioni
Gene expression databases
Bgeei | ENSPTRG00000001672, Expressed in heart and 6 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the FMO family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1399, Eukaryota |
GeneTreei | ENSGT00940000161099 |
HOGENOMi | CLU_006909_8_2_1 |
InParanoidi | Q8HZ70 |
OMAi | DCYERET |
OrthoDBi | 405736at2759 |
TreeFami | TF105285 |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR000960, Flavin_mOase IPR020946, Flavin_mOase-like IPR002254, Flavin_mOase_2 |
Pfami | View protein in Pfam PF00743, FMO-like, 1 hit |
PIRSFi | PIRSF000332, FMO, 1 hit |
PRINTSi | PR00370, FMOXYGENASE PR01122, FMOXYGENASE2 |
SUPFAMi | SSF51905, SSF51905, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8HZ70-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKKVAVIGA GVSGLISLKC CVDEGLEPTC FERTEDIGGV WRFKENVEDG
60 70 80 90 100
RASIYQSVIT NTSKEMSCFS DFPMPEDFPN FLHNSKLLEY FRIFAKKFDL
110 120 130 140 150
LKYIQFQTTV LSVRKCPDFS SSGQWKVVTQ SNGKEQSAVF DAVMVCSGHH
160 170 180 190 200
ILPHIPLKSF PGIERFKGQY FHSRQYKHPD GFEGKRILVI GMGNSGSDIA
210 220 230 240 250
VELSKNAAQV FISTRHGTWV MSRISEDGYP WDSVFHTRFR SMLRNVLPRT
260 270 280 290 300
AVKWMIEQQM NRWFNHENYG LEPQNKYIMK EPVLNDDVPS RLLCGAIKVK
310 320 330 340 350
STVKELTETS AIFEDGTVEE NIDVIIFATG YSFSFPFLED SLVKVENNMV
360 370 380 390 400
SLYKYIFPAH LDKSTLACIG LIQPLGSIFP TAELQARWVT RVFKGLCSLP
410 420 430 440 450
SERTMMMDII KRNEKRIDLF GESQSQTLQT NYVDYLDELA LEIGAKPDFC
460 470 480 490 500
SLLFKDPKLA VRLYFGPCNS YQYRLVGPGQ WEGARNAIFT QKQRILKPLK
510 520 530
TRALKDSSNF SVSFLLKILG LLAVVVAFFC QLQWS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY132298 , AY132291, AY132292, AY132293, AY132294, AY132295, AY132296, AY132297 Genomic DNA Translation: AAN06319.1 |
RefSeqi | NP_001009008.1, NM_001009008.2 |
Genome annotation databases
Ensembli | ENSPTRT00000003028; ENSPTRP00000002780; ENSPTRG00000001672 |
GeneIDi | 449587 |
KEGGi | ptr:449587 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY132298 , AY132291, AY132292, AY132293, AY132294, AY132295, AY132296, AY132297 Genomic DNA Translation: AAN06319.1 |
RefSeqi | NP_001009008.1, NM_001009008.2 |
3D structure databases
AlphaFoldDBi | Q8HZ70 |
SMRi | Q8HZ70 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000002780 |
Proteomic databases
PaxDbi | Q8HZ70 |
Genome annotation databases
Ensembli | ENSPTRT00000003028; ENSPTRP00000002780; ENSPTRG00000001672 |
GeneIDi | 449587 |
KEGGi | ptr:449587 |
Organism-specific databases
CTDi | 2327 |
VGNCi | VGNC:543, FMO2 |
Phylogenomic databases
eggNOGi | KOG1399, Eukaryota |
GeneTreei | ENSGT00940000161099 |
HOGENOMi | CLU_006909_8_2_1 |
InParanoidi | Q8HZ70 |
OMAi | DCYERET |
OrthoDBi | 405736at2759 |
TreeFami | TF105285 |
Gene expression databases
Bgeei | ENSPTRG00000001672, Expressed in heart and 6 other tissues |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR000960, Flavin_mOase IPR020946, Flavin_mOase-like IPR002254, Flavin_mOase_2 |
Pfami | View protein in Pfam PF00743, FMO-like, 1 hit |
PIRSFi | PIRSF000332, FMO, 1 hit |
PRINTSi | PR00370, FMOXYGENASE PR01122, FMOXYGENASE2 |
SUPFAMi | SSF51905, SSF51905, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | FMO2_PANTR | |
Accessioni | Q8HZ70Primary (citable) accession number: Q8HZ70 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 21, 2003 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 125 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families