UniProtKB - Q8HYS0 (CCL5_CANLF)
Protein
C-C motif chemokine 5
Gene
CCL5
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.By similarity
GO - Molecular functioni
- CCR1 chemokine receptor binding Source: InterPro
- CCR4 chemokine receptor binding Source: InterPro
- CCR5 chemokine receptor binding Source: InterPro
- chemokine activity Source: InterPro
GO - Biological processi
- chemokine-mediated signaling pathway Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: UniProtKB
- immune response Source: InterPro
- inflammatory response Source: UniProtKB-KW
- regulation of insulin secretion Source: UniProtKB
- regulation of neuron death Source: UniProtKB
- response to virus Source: InterPro
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Names & Taxonomyi
Protein namesi | Recommended name: C-C motif chemokine 5Alternative name(s): Small-inducible cytokine A5 T-cell-specific protein RANTES |
Gene namesi | Name:CCL5 Synonyms:SCYA5 |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000005171 | 24 – 91 | C-C motif chemokine 5Add BLAST | 68 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 33 ↔ 57 | By similarity | ||
Disulfide bondi | 34 ↔ 73 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | Q8HYS0 |
Interactioni
GO - Molecular functioni
- CCR1 chemokine receptor binding Source: InterPro
- CCR4 chemokine receptor binding Source: InterPro
- CCR5 chemokine receptor binding Source: InterPro
- chemokine activity Source: InterPro
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000026835 |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine beta (chemokine CC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S8D1, Eukaryota |
InParanoidi | Q8HYS0 |
OrthoDBi | 1575018at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR030595, CCL5 IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit PTHR12015:SF82, PTHR12015:SF82, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8HYS0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVSAATFAI LLATATFRAP ASASPYASDT TPCCFAYISG RLPFTHVQEY
60 70 80 90
FYTSSKCSMP AVVFVTRKHR QVCANPQKKW VREYINSLEM S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB098562 mRNA Translation: BAC53725.1 |
RefSeqi | NP_001003010.1, NM_001003010.2 |
Genome annotation databases
GeneIDi | 403522 |
KEGGi | cfa:403522 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB098562 mRNA Translation: BAC53725.1 |
RefSeqi | NP_001003010.1, NM_001003010.2 |
3D structure databases
SMRi | Q8HYS0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000026835 |
Proteomic databases
PaxDbi | Q8HYS0 |
Genome annotation databases
GeneIDi | 403522 |
KEGGi | cfa:403522 |
Organism-specific databases
CTDi | 6352 |
Phylogenomic databases
eggNOGi | ENOG502S8D1, Eukaryota |
InParanoidi | Q8HYS0 |
OrthoDBi | 1575018at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR030595, CCL5 IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit PTHR12015:SF82, PTHR12015:SF82, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCL5_CANLF | |
Accessioni | Q8HYS0Primary (citable) accession number: Q8HYS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families