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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.By similarity

Catalytic activityi

A C(21)-steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 17-alpha-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity
17-alpha-hydroxyprogesterone + [reduced NADPH--hemoprotein reductase] + O2 = androstenedione + acetate + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity
17-alpha-hydroxypregnenolone + [reduced NADPH--hemoprotein reductase] + O2 = 3-beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

hemeBy similarity

Pathwayi: steroid biosynthesis

This protein is involved in the pathway steroid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway steroid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi442Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Monooxygenase, Oxidoreductase
Biological processSteroidogenesis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00062

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.14.19By similarity, EC:1.14.14.32By similarity)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:CYP17A1
Synonyms:CYP17
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519331 – 508Steroid 17-alpha-hydroxylase/17,20 lyaseAdd BLAST508

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000023165

Structurei

3D structure databases

ProteinModelPortaliQ8HYM9
SMRiQ8HYM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
HOGENOMiHOG000036991
HOVERGENiHBG106944
InParanoidiQ8HYM9
KOiK00512

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q8HYM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWELVALLLL TLAYLFWPKR RCPGAKYPKS LLSLPLVGSL PFLPRHGHMH
60 70 80 90 100
NNFFKLQKKY GPIYSVRMGT KTTVIVGHHQ LAKEVLIKKG KDFSGRPQVT
110 120 130 140 150
TLDILSNNRK GIAFADYGAH WQLHRRLAMA TFALFKDGDQ KLEKIICQEI
160 170 180 190 200
STLCDMLATH NGQTIDISFP VFVAITNVIS LICFNISYKN GDPELKIVHN
210 220 230 240 250
YNEGIIDSLG KESLVDLFPW LKVFPNKTLE KLKRHVKTRN DLLTKIFENY
260 270 280 290 300
KEKFHSDSIT NMLDVLMQAK MNSDNGNAGP DQDSELLSDN HILTTIGDIF
310 320 330 340 350
GAGVETTTSV VKWIVAFLLH NPQVKKKLYE EIDQNVGFSR TPTISDRNRL
360 370 380 390 400
LLLEATIREV LRIRPVAPML IPHKANVDSS IGEFAVDKGT HVIINLWALH
410 420 430 440 450
HNEKEWHQPD QFMPERFLNP AGTQLISPSL SYLPFGAGPR SCIGEILARQ
460 470 480 490 500
ELFLIMAWLL QRFDLEVPDD GQLPSLEGNP KVVFLIDSFK VKIKVRQAWR

EAQAEGST
Length:508
Mass (Da):57,619
Last modified:March 1, 2003 - v1
Checksum:i92D7FFDF81398063
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458332 mRNA Translation: AAN86253.1
RefSeqiNP_001035322.1, NM_001040232.1
UniGeneiMmu.2608

Genome annotation databases

GeneIDi678693
KEGGimcc:678693

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458332 mRNA Translation: AAN86253.1
RefSeqiNP_001035322.1, NM_001040232.1
UniGeneiMmu.2608

3D structure databases

ProteinModelPortaliQ8HYM9
SMRiQ8HYM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000023165

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi678693
KEGGimcc:678693

Organism-specific databases

CTDi1586

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
HOGENOMiHOG000036991
HOVERGENiHBG106944
InParanoidiQ8HYM9
KOiK00512

Enzyme and pathway databases

UniPathwayi
UPA00062

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP17A_MACMU
AccessioniPrimary (citable) accession number: Q8HYM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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