We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q8HXX8 (GCDH_MACFA)
Protein
Glutaryl-CoA dehydrogenase, mitochondrial
Gene
GCDH
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Functioni
Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2 in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor (By similarity).
By similarityCatalytic activityi
- glutaryl-CoA + 2 H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]EC:1.3.8.6
Cofactori
FADBy similarity
: lysine degradation Pathwayi
This protein is involved in the pathway lysine degradation, which is part of Amino-acid metabolism.View all proteins of this organism that are known to be involved in the pathway lysine degradation and in Amino-acid metabolism.
Pathwayi: tryptophan metabolism
This protein is involved in the pathway tryptophan metabolism, which is part of Amino-acid metabolism.View all proteins of this organism that are known to be involved in the pathway tryptophan metabolism and in Amino-acid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 186 | FADBy similarity | 1 | |
Binding sitei | 186 | Substrate; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 294 | SubstrateBy similarity | 1 | |
Binding sitei | 319 | FADBy similarity | 1 | |
Binding sitei | 330 | FADBy similarity | 1 | |
Active sitei | 414 | Proton acceptorBy similarity | 1 | |
Binding sitei | 415 | Substrate; via amide nitrogenBy similarity | 1 | |
Binding sitei | 416 | FADBy similarity | 1 | |
Binding sitei | 434 | FAD; via carbonyl oxygenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 177 – 186 | FADBy similarity | 10 | |
Nucleotide bindingi | 177 – 180 | FADBy similarity | 4 | |
Nucleotide bindingi | 212 – 214 | FADBy similarity | 3 | |
Nucleotide bindingi | 387 – 391 | FADBy similarity | 5 | |
Nucleotide bindingi | 416 – 418 | FADBy similarity | 3 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
- glutaryl-CoA dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- fatty acid beta-oxidation using acyl-CoA dehydrogenase Source: UniProtKB
- tryptophan metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
UniPathwayi | UPA00224 UPA00225 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GCDH ORF Names:QccE-20069 |
Organismi | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
Taxonomic identifieri | 9541 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 44 | MitochondrionSequence analysisAdd BLAST | 44 | |
ChainiPRO_0000000527 | 45 – 438 | Glutaryl-CoA dehydrogenase, mitochondrialAdd BLAST | 394 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 240 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationInteractioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
STRINGi | 9541.XP_005588222.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 138 – 139 | Substrate bindingBy similarity | 2 | |
Regioni | 287 – 294 | Substrate bindingBy similarity | 8 |
Sequence similaritiesi
Belongs to the acyl-CoA dehydrogenase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0138, Eukaryota |
OrthoDBi | 589058at2759 |
Family and domain databases
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR006089, Acyl-CoA_DH_CS IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR013786, AcylCoA_DH/ox_N IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF00441, Acyl-CoA_dh_1, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit PF02771, Acyl-CoA_dh_N, 1 hit |
SUPFAMi | SSF47203, SSF47203, 1 hit SSF56645, SSF56645, 1 hit |
PROSITEi | View protein in PROSITE PS00072, ACYL_COA_DH_1, 1 hit PS00073, ACYL_COA_DH_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8HXX8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALRGVSVQL LSRVPGLRVF RTWVSSAAQT EKVGRTQSQL AKSSRPEFDW
60 70 80 90 100
RDPLVLEEQL TTDEILIRDT FRTYCQERLM PRILLANRNE VFHREIISQM
110 120 130 140 150
GELGVLGPTI KGYGCAGVSS VAYGLLAREL ERVDSGYRSA MSVQSPLVMH
160 170 180 190 200
PIYAYGSEEQ RQKYLPRLAK GELLGCFGLT EPNSGSDPSS METRARYNSS
210 220 230 240 250
NKSYTLNGTK TWITNSPMAD LFVVWARCED GRIRGFLLEK GMRGLSAPRI
260 270 280 290 300
QGKFSLRASA TGMIIMDGVE VPEENMLPGA SSLGGSFGCL NNGRYGIAWG
310 320 330 340 350
VLGASEFCLH TARQYALDRM QFGVPLARNQ LIQKKLADML TEITLGLHAC
360 370 380 390 400
LQLGRLKDQD KAAPEMVSLL KRNNCGKALD IARQARDMLG GNGISDEYHV
410 420 430
IRHAMNLEAV NTYEGTHDIH ALILGRAITG IQAFTASK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB083311 mRNA Translation: BAC20590.1 |
RefSeqi | NP_001271544.1, NM_001284615.1 |
Genome annotation databases
GeneIDi | 102119324 |
KEGGi | mcf:102119324 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB083311 mRNA Translation: BAC20590.1 |
RefSeqi | NP_001271544.1, NM_001284615.1 |
3D structure databases
SMRi | Q8HXX8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9541.XP_005588222.1 |
Genome annotation databases
GeneIDi | 102119324 |
KEGGi | mcf:102119324 |
Organism-specific databases
CTDi | 2639 |
Phylogenomic databases
eggNOGi | KOG0138, Eukaryota |
OrthoDBi | 589058at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00224 UPA00225 |
Family and domain databases
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR006089, Acyl-CoA_DH_CS IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR013786, AcylCoA_DH/ox_N IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF00441, Acyl-CoA_dh_1, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit PF02771, Acyl-CoA_dh_N, 1 hit |
SUPFAMi | SSF47203, SSF47203, 1 hit SSF56645, SSF56645, 1 hit |
PROSITEi | View protein in PROSITE PS00072, ACYL_COA_DH_1, 1 hit PS00073, ACYL_COA_DH_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GCDH_MACFA | |
Accessioni | Q8HXX8Primary (citable) accession number: Q8HXX8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 12, 2005 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families