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Entry version 115 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Probable inactive DNA (cytosine-5)-methyltransferase DRM3

Gene

DRM3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytically inactive DNA methyltransferase that acts as regulatory factor for DRM2-mediated DNA methylation. Required for maintenance of non-CpG DNA methylation. Required for normal establishment and maintenance of RNA-directed DNA methylation (RdDM) and accumulation of specific repeat-associated small interfering RNAs (siRNAs) (PubMed:21060858, PubMed:25316414, PubMed:25561521). Required for nucleolus organizer region (NOR) nuclear organization during interphase (PubMed:25316414). Acts downstream of the production of siRNAs. May promote RNA polymerase V (Pol V) transcriptional elongation or assist in the stabilization of Pol V transcripts (PubMed:25561521).3 Publications

Caution

Lacks the conserved tripeptide Ser-Pro-Cys in position 672 necessary for the methyltransferase activity in DRM protein (AC Q9M548).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • DNA methylation Source: TAIR

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Methyltransferase, Transferase
LigandS-adenosyl-L-methionine

Protein family/group databases

Restriction enzymes and methylases database

More...
REBASEi
12266, M.AthDRM3
4601, M.AthDRM2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable inactive DNA (cytosine-5)-methyltransferase DRM3Curated
Alternative name(s):
Protein DOMAINS REARRANGED METHYLTRANSFERASE 31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DRM31 Publication
Ordered Locus Names:At3g17310Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G17310

The Arabidopsis Information Resource

More...
TAIRi
locus:2089075, AT3G17310

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004381551 – 710Probable inactive DNA (cytosine-5)-methyltransferase DRM3Add BLAST710

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8H1E8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
224354

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8H1E8, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Pol V.

1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8H1E8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT3G17310.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8H1E8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 92UBA 1PROSITE-ProRule annotationAdd BLAST41
Domaini198 – 242UBA 2PROSITE-ProRule annotationAdd BLAST45
Domaini379 – 710SAM-dependent MTase DRM-typePROSITE-ProRule annotationAdd BLAST332

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DRM-methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QS8G, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006805_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8H1E8

Identification of Orthologs from Complete Genome Data

More...
OMAi
ENDLTHR

Database of Orthologous Groups

More...
OrthoDBi
412711at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8H1E8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029063, SAM-dependent_MTases
IPR030380, SAM_MeTfrase_DRM

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51680, SAM_MT_DRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8H1E8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADMRRRNGS GGSSNHERNE QILFPKPETL DFDLPCDTSF PQQIGDNAAS
60 70 80 90 100
SSGSNVKSLL IEMGFCPTLV QKAIDENGQD DFELLLEILT KSTETEPPGP
110 120 130 140 150
SFHGLMEPKP EPDIEYETDR IRIALLTMKF PENLVDFALD RLGKDTPIDE
160 170 180 190 200
MVDFIVAAQL AEKYAEESED SLDGAEINEE DEDVTPVTAR GPEVPNEQLF
210 220 230 240 250
ETMDKTLRLL EMGFSNDEIS MAIEKIGTKG QISVLAESIV TGEFPAECHD
260 270 280 290 300
DLEDIEKKVS AAAPAVNRTC LSKSWRFVGV GAQKEDGGGG SSSGTANIKP
310 320 330 340 350
DPGIESFPFP ATDNVGETSR GKRPKDEDEN AYPEEYTGYD DRGKRLRPED
360 370 380 390 400
MGDSSSFMET PWMQDEWKDN TYEFPSVMQP RLSQSLGPKV ARRPYFFYGQ
410 420 430 440 450
LGELSPSWWS KISGFLFGIH PEHVDTRLCS ALRRTEGYLH NLPTVNRFNT
460 470 480 490 500
LPNPRLTIQD AMPHMRSWWP QWDIRKHFNS GTCSNMKDAT LLCERIGRRI
510 520 530 540 550
AECKGKPTQQ DQTLILRHCH TSNLIWIAPN ILSPLEPEHL ECIMGYPMNH
560 570 580 590 600
TNIGGGRLAE RLKLFDYCFQ TDTLGYHLSV LKSMFPQGLT VLSLFSGIGG
610 620 630 640 650
AEIALDRLGI HLKGVVSVES CGLSRNILKR WWQTSGQTGE LVQIEEIKSL
660 670 680 690 700
TAKRLETLMQ RFGGFDFVIC QNPSTPLDLS KEISNSEACE FDYTLFNEFA
710
RVTKRVRDMM
Length:710
Mass (Da):79,731
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA744D7722CB80AE6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1I9LSG4A0A1I9LSG4_ARATH
S-adenosyl-L-methionine-dependent m...
DRM3 AtDRM3, At3g17310
591Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB02735 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77N → S in AAK92819 (PubMed:19423640).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB022216 Genomic DNA Translation: BAB02735.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE75935.1
CP002686 Genomic DNA Translation: AEE75936.1
AY050882 mRNA Translation: AAK92819.1
AY150440 mRNA Translation: AAN12982.1
AK316724 mRNA Translation: BAH19451.1

NCBI Reference Sequences

More...
RefSeqi
NP_566573.1, NM_112609.3
NP_850603.1, NM_180272.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G17310.1; AT3G17310.1; AT3G17310
AT3G17310.2; AT3G17310.2; AT3G17310

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
820994

Gramene; a comparative resource for plants

More...
Gramenei
AT3G17310.1; AT3G17310.1; AT3G17310
AT3G17310.2; AT3G17310.2; AT3G17310

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G17310

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022216 Genomic DNA Translation: BAB02735.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE75935.1
CP002686 Genomic DNA Translation: AEE75936.1
AY050882 mRNA Translation: AAK92819.1
AY150440 mRNA Translation: AAN12982.1
AK316724 mRNA Translation: BAH19451.1
RefSeqiNP_566573.1, NM_112609.3
NP_850603.1, NM_180272.2

3D structure databases

SMRiQ8H1E8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8H1E8, 1 interactor
STRINGi3702.AT3G17310.1

Protein family/group databases

REBASEi12266, M.AthDRM3
4601, M.AthDRM2

Proteomic databases

PaxDbiQ8H1E8
ProteomicsDBi224354

Genome annotation databases

EnsemblPlantsiAT3G17310.1; AT3G17310.1; AT3G17310
AT3G17310.2; AT3G17310.2; AT3G17310
GeneIDi820994
GrameneiAT3G17310.1; AT3G17310.1; AT3G17310
AT3G17310.2; AT3G17310.2; AT3G17310
KEGGiath:AT3G17310

Organism-specific databases

AraportiAT3G17310
TAIRilocus:2089075, AT3G17310

Phylogenomic databases

eggNOGiENOG502QS8G, Eukaryota
HOGENOMiCLU_006805_3_1_1
InParanoidiQ8H1E8
OMAiENDLTHR
OrthoDBi412711at2759
PhylomeDBiQ8H1E8

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8H1E8

Gene expression databases

ExpressionAtlasiQ8H1E8, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR029063, SAM-dependent_MTases
IPR030380, SAM_MeTfrase_DRM
SUPFAMiSSF53335, SSF53335, 2 hits
PROSITEiView protein in PROSITE
PS51680, SAM_MT_DRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRM3_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8H1E8
Secondary accession number(s): Q949U6, Q9LUU0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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