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Entry version 138 (29 Sep 2021)
Sequence version 3 (03 May 2011)
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Protein

E3 ubiquitin-protein ligase UPL2

Gene

UPL2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3625Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UPL2 (EC:2.3.2.26)
Short name:
Ubiquitin-protein ligase 2
Alternative name(s):
HECT-type E3 ubiquitin transferase UPL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UPL2
Ordered Locus Names:At1g70320
ORF Names:F17O7.14/F17O7.15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G70320

The Arabidopsis Information Resource

More...
TAIRi
locus:2016174, AT1G70320

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001203441 – 3658E3 ubiquitin-protein ligase UPL2Add BLAST3658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2582PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8H0T4

PRoteomics IDEntifications database

More...
PRIDEi
Q8H0T4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
234117

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8H0T4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in root, stem, cauline and rosette leaf, seedling and flower (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Constitutively expressed throughout development post-germination (at protein level).1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8H0T4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8H0T4, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
28588, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8H0T4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT1G70320.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8H0T4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1271 – 1312UBAPROSITE-ProRule annotationAdd BLAST42
Domaini1318 – 1337UIMPROSITE-ProRule annotationAdd BLAST20
Domaini3317 – 3658HECTPROSITE-ProRule annotationAdd BLAST342

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni884 – 914DisorderedSequence analysisAdd BLAST31
Regioni1331 – 1360DisorderedSequence analysisAdd BLAST30
Regioni1702 – 1733DisorderedSequence analysisAdd BLAST32
Regioni2004 – 2038DisorderedSequence analysisAdd BLAST35
Regioni2052 – 2072DisorderedSequence analysisAdd BLAST21
Regioni2113 – 2204DisorderedSequence analysisAdd BLAST92
Regioni2293 – 2313DisorderedSequence analysisAdd BLAST21
Regioni2417 – 2487DisorderedSequence analysisAdd BLAST71
Regioni2503 – 2591DisorderedSequence analysisAdd BLAST89
Regioni2958 – 2987DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1338 – 1360Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi2012 – 2031Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi2118 – 2144Acidic residuesSequence analysisAdd BLAST27
Compositional biasi2160 – 2204Acidic residuesSequence analysisAdd BLAST45
Compositional biasi2294 – 2313Polar residuesSequence analysisAdd BLAST20
Compositional biasi2417 – 2436Polar residuesSequence analysisAdd BLAST20
Compositional biasi2503 – 2518Polar residuesSequence analysisAdd BLAST16
Compositional biasi2534 – 2571Polar residuesSequence analysisAdd BLAST38
Compositional biasi2968 – 2987Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPL family. TOM1/PTR1 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0939, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000215_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8H0T4

Identification of Orthologs from Complete Genome Data

More...
OMAi
LAHATCT

Database of Orthologous Groups

More...
OrthoDBi
25515at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078, HECTc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR010309, E3_Ub_ligase_DUF908
IPR010314, E3_Ub_ligase_DUF913
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR025527, HUWE1/Rev1_UBM
IPR015940, UBA
IPR009060, UBA-like_sf
IPR003903, UIM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06012, DUF908, 2 hits
PF06025, DUF913, 1 hit
PF00632, HECT, 1 hit
PF00627, UBA, 1 hit
PF14377, UBM, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119, HECTc, 1 hit
SM00165, UBA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934, SSF46934, 1 hit
SSF48371, SSF48371, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237, HECT, 1 hit
PS50030, UBA, 1 hit
PS50330, UIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8H0T4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLRRRRASE VPTKISLFIN SVTSVPLELI QEPLASFRWE FDKGDFHHWV
60 70 80 90 100
DLFYHFDTFF EKHVKVRKDL RIEEEFDESD PPFPKDAVLQ VLRVIRLVLE
110 120 130 140 150
NCTNKQFYTS YEQHLSLLLA STDADVVEAC LQTLAAFLKR PTGKYSIRDA
160 170 180 190 200
SLNLKLFSLA QGWGGKEEGL GLTSCATEHS CDQLFLQLGC TLLFEFYASD
210 220 230 240 250
ESPSELPGGL QVIHVPDVSM RSESDLELLN KLVIDHNVPP SLRFALLTRL
260 270 280 290 300
RFARAFSSLA TRQQYTCIRL YAFIVLVQAS GDTENVVSFF NGEPEFVNEL
310 320 330 340 350
VTLVSYEDTV PAKIRILCLQ SLVALSQDRT RQPTVLTAVT SGGHRGLLSG
360 370 380 390 400
LMQKAIDSVI CNTSKWSLAF AEALLSLVTV LVSSSSGCSA MREAGLIPTL
410 420 430 440 450
VPLIKDTDPQ HLHLVSTAVH ILEVFMDYSN PAAALFRDLG GLDDTIFRLK
460 470 480 490 500
QEVSRTEDDV KEIVCCSGSN GPEDDTEQLP YSEALISYHR RLLLKALLRA
510 520 530 540 550
ISLGTYAPGN TNLYGSEESL LPECLCIIFR RAKDFGGGVF SLAATVMSDL
560 570 580 590 600
IHKDPTCFNA LDSAGLTSAF LDAISDEVIC SAEAITCIPQ CLDALCLNNS
610 620 630 640 650
GLQAVKDRNA LRCFVKIFSS PSYLKALTSD TPGSLSSGLD ELLRHQSSLR
660 670 680 690 700
TYGVDMFIEI LNSILIIGSG MEATTSKSAD VPTDAAPVPM EIDVDEKSLA
710 720 730 740 750
VSDEAEPSSD TSPANIELFL PDCVCNVARL FETVLQNAEV CSLFVEKKGI
760 770 780 790 800
DTVLQLFSLP LMPLSTSLGQ SFSVAFKNFS PQHSAGLARI LCSYLREHLK
810 820 830 840 850
KTNNLLVSIE GTQLLKLESA VQTKILRSLS CLEGMLSLSN FLLKGSASVI
860 870 880 890 900
SELSAANADV LKELGITYKQ TIWQMALCND TKEDEKKSVD RASDNSVSAS
910 920 930 940 950
SSTAERESDE DSSNALAVRY TNPVSIRSSS SQSIWGGHRE FLSVVRSGRG
960 970 980 990 1000
VHGHTRHAIA RMRGGRTRRH LESFNFDSEI PADLPVTSSS HELKKKSTEV
1010 1020 1030 1040 1050
LIAEILNKLN CTLRFFFTSL VKGFTSANRR RIDGPSLSSA SKTLGTALAK
1060 1070 1080 1090 1100
VFLEALNFQG YGAAAGPDTS LSLKCRYLGK VVDDITFLTF DTRRRVCFTA
1110 1120 1130 1140 1150
MVNSFYVHGT FKELLTTFEA TSQLLWKVPF SIRASSTENE KSGERNLWSH
1160 1170 1180 1190 1200
SKWLVDTLQN YCRALDYFVN STYLLSPTSQ TQLLVQPASV DLSIGLFPVP
1210 1220 1230 1240 1250
REPETFVRNL QSQVLEVILP IWNHPMFPDC NPNFVASVTS LVTHIYSGVV
1260 1270 1280 1290 1300
DTRENRSGAT QGTNQRALPL QPDEAIVGMI VEMGFSRSRA EDALRRVGTN
1310 1320 1330 1340 1350
SVEMAMDWLF TNPEDPVQED DELAQALALS LGNSSETPKL EDTEKPVDVP
1360 1370 1380 1390 1400
QEEAEPKEPP VDEVIAASVK LFQSDDSIAF PLVDLFVTLC NRNKGEDRPK
1410 1420 1430 1440 1450
IVFYLIQQLK LVQLDFSKDT GALTMIPHIL ALVLSEDDNT REIAAQDGIV
1460 1470 1480 1490 1500
AVAIGILTDF NLKSESETDI LAPKCISALL LVLSMMLQAQ TRLSSEYVEG
1510 1520 1530 1540 1550
NQGGSLVLSD SPQDSTAALK DALSSDVAKG ESNQALESMF GKSTGYLTME
1560 1570 1580 1590 1600
ESSKVLLIAC GLIKQRVPAM IMQAVLQLCA RLTKSHALAI QFLENGGLSS
1610 1620 1630 1640 1650
LFNLPKKCFF PGYDTVASVI VRHLVEDPQT LQIAMETEIR QTLSGKRHIG
1660 1670 1680 1690 1700
RVLPRTFLTT MAPVISRDPV VFMKAVASTC QLESSGGTDF VILTKEKEKP
1710 1720 1730 1740 1750
KVSGSEHGFS LNEPLGISEN KLHDGSGKCS KSHRRVPTNF IQVIDQLIDI
1760 1770 1780 1790 1800
VLSFPGLKRQ EGEAANLISM DVDEPTTKVK GKSKVGEPEK AELGSEKSEE
1810 1820 1830 1840 1850
LARVTFILKL LSDIVLMYLH GTSVILRRDT EISQLRGSNL PDDSPGNGGL
1860 1870 1880 1890 1900
IYHVIHRLLP ISLEKFVGPE EWKEKLSEKA SWFLVVLCSR SNEGRKRIIN
1910 1920 1930 1940 1950
ELTRVLSVFA SLGRSSSQSV LLPDKRVLAF ANLVYSILTK NSSSSNFPGC
1960 1970 1980 1990 2000
GCSPDVAKSM IDGGTIQCLT SILNVIDLDH PDAPKLVTLI LKSLETLTRA
2010 2020 2030 2040 2050
ANAAEQLKSE VPNEQKNTDS DERHDSHGTS TSTEVDELNQ NNSSLQQVTD
2060 2070 2080 2090 2100
AVDNGQEQPQ VSSQSEGERG SSLTQAMLQE MRIEGDETIL PEPIQMDFFR
2110 2120 2130 2140 2150
EEIEGDQIEM SFHVEDRADD DVDDDMDDEG EDDEGDDEDA DSVEDGAGVM
2160 2170 2180 2190 2200
SIAGTDVEDP EDTGLGDEYN DDMVDEDEED EDEYNDDMVD EDEDDEDEYN
2210 2220 2230 2240 2250
DDMVDEDEDD FHETRVIEVR WREALDGLDH FQIVGRSGGG NGFIDDITAE
2260 2270 2280 2290 2300
PFEGVNVDDL FALRRSLGFE RRRQTGRSSF DRSGSEVHGF QHPLFSRPSQ
2310 2320 2330 2340 2350
TGNTASVSAS AGSISRHSEA GSYDVAQFYM FDSPVLPFDQ VPVDPFSDRL
2360 2370 2380 2390 2400
GGGGAPPPLT DYSVVGMDSS RRGVGDSRWT DVGHPQPSSL SASIAQLIEE
2410 2420 2430 2440 2450
HFITNLRASA PVDTVVERET NTTEVQEQQQ PDVPPSVGSE TVLGDGNEGG
2460 2470 2480 2490 2500
EQSEEHELLN NNEVMHPLPL NSTPNEIDRM EVGEGGGAPI EQVDREAVHL
2510 2520 2530 2540 2550
ISSAQGQSDT SGIQNVSVTA IPPPVDDPDS NFQPSVDVDM SSDGAEGNQS
2560 2570 2580 2590 2600
VQPSPLDGDN NELSSMEATQ DVRNDEQVDE GSLDGRAPEV NAIDPTFLEA
2610 2620 2630 2640 2650
LPEDLRAEVL ASQQAQSVQP PTYEPPSVDD IDPEFLAALP PEIQREVLAQ
2660 2670 2680 2690 2700
QRAQRMLQQS QGQPVDMDNA SIIATLPADL REEVLLTSSE AVLAALPPPL
2710 2720 2730 2740 2750
LAEAQMLRDR AMRHYQARSR VFGSSHRLNN RRNGLGYRLT GMERGVGVTI
2760 2770 2780 2790 2800
GQRDVSSSAD GLKVKEIEGD PLVNADALKS LIRLLRLAQP LGKGLLQRLL
2810 2820 2830 2840 2850
LNLCAHSFTR ANLVQLLLDM IRPEMETLPS ELALTNPQRL YGCQLNVVYG
2860 2870 2880 2890 2900
RSQLLNGLPP LVFRRVLEVL TYLATNHSAV ADMLFYFDSS LLSQLSSRKG
2910 2920 2930 2940 2950
KEKVTHETDS RDLEIPLVVF LKLLNRPQLL QSTSHLALVM GLLQVVVYTA
2960 2970 2980 2990 3000
ASRIEGWSPS SGVPEKLENK PVGEEASSET QKDAESELSV ARRKNCAELY
3010 3020 3030 3040 3050
NIFLQLPQSD LCNLCMLLGY EGLSDKIYSL AGEVLKKLAA VDVTHRKFFT
3060 3070 3080 3090 3100
KELSELASGL SSSTVRVLAT LSTTQKMSQN TCSMAGASIL RVLQVLSSLT
3110 3120 3130 3140 3150
STIDDSNVGT DKETDQEEQN IMQGLKVALE PLWQELGQCI SMTELQLDHT
3160 3170 3180 3190 3200
AATSNVNPGD HVLGISPTSS LSPGTQSLLP LIEAFFVLCE KIQTPSMLQQ
3210 3220 3230 3240 3250
DATVTAGEVK ESSTHGSSSK TIVDSQKKID GSVTFSKFVE KHRRLLNSFV
3260 3270 3280 3290 3300
RQNPSLLEKS FSMMLKAPRL IDFDNKKAYF RSRIRHQHDQ HISGPLRISV
3310 3320 3330 3340 3350
RRAYVLEDSY NQLRMRSPQD LKGRLNVQFQ GEEGIDAGGL TREWYQLLSR
3360 3370 3380 3390 3400
VIFDKGALLF TTVGNDATFQ PNPNSVYQTE HLSYFKFVGR MVAKALFDGQ
3410 3420 3430 3440 3450
LLDVYFTRSF YKHILGVKVT YHDIEAVDPD YYKNLKWLLE NDVSDILDLT
3460 3470 3480 3490 3500
FSMDADEEKH ILYEKTEVTD YELKPGGRNI RVTEETKHEY VDLVADHILT
3510 3520 3530 3540 3550
SAIRPQINAF LEGLNELIPR ELVSIFNDKE LELLISGLPE IDFDDLKANT
3560 3570 3580 3590 3600
EYTSYTVGSP VIRWFWEVVK AFSKEDMARF LQFVTGTSKV PLEGFKALQG
3610 3620 3630 3640 3650
ISGPQRLQIH KAYGSPERLP SAHTCFNQLD LPEYQSKEQV QERLLLAIHE

ANEGFGFA
Length:3,658
Mass (Da):403,616
Last modified:May 3, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6D74894C0264444
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC18812 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes.Curated
The sequence AAC18813 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes.Curated
The sequence AAN72076 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti153 – 154NL → ES in AAF36455 (PubMed:10571878).Curated2
Sequence conflicti263Q → R in AAF36455 (PubMed:10571878).Curated1
Sequence conflicti1759R → S in AAF36455 (PubMed:10571878).Curated1
Sequence conflicti1771D → N in AAF36455 (PubMed:10571878).Curated1
Sequence conflicti2322S → I in AAF36455 (PubMed:10571878).Curated1
Sequence conflicti3298I → F in AAN72076 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF127565 Genomic DNA Translation: AAF36455.1
AC003671 Genomic DNA Translation: AAC18812.1 Sequence problems.
AC003671 Genomic DNA Translation: AAC18813.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE35045.1
AK230373 mRNA Translation: BAF02172.1
BT002065 mRNA Translation: AAN72076.1 Different initiation.
BT008830 mRNA Translation: AAP68269.1

Protein sequence database of the Protein Information Resource

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PIRi
T01490
T01491

NCBI Reference Sequences

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RefSeqi
NP_177189.1, NM_105700.3

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT1G70320.1; AT1G70320.1; AT1G70320

Database of genes from NCBI RefSeq genomes

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GeneIDi
843368

Gramene; a comparative resource for plants

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Gramenei
AT1G70320.1; AT1G70320.1; AT1G70320

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT1G70320

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127565 Genomic DNA Translation: AAF36455.1
AC003671 Genomic DNA Translation: AAC18812.1 Sequence problems.
AC003671 Genomic DNA Translation: AAC18813.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE35045.1
AK230373 mRNA Translation: BAF02172.1
BT002065 mRNA Translation: AAN72076.1 Different initiation.
BT008830 mRNA Translation: AAP68269.1
PIRiT01490
T01491
RefSeqiNP_177189.1, NM_105700.3

3D structure databases

SMRiQ8H0T4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi28588, 5 interactors
IntActiQ8H0T4, 1 interactor
STRINGi3702.AT1G70320.1

PTM databases

iPTMnetiQ8H0T4

Proteomic databases

PaxDbiQ8H0T4
PRIDEiQ8H0T4
ProteomicsDBi234117

Genome annotation databases

EnsemblPlantsiAT1G70320.1; AT1G70320.1; AT1G70320
GeneIDi843368
GrameneiAT1G70320.1; AT1G70320.1; AT1G70320
KEGGiath:AT1G70320

Organism-specific databases

AraportiAT1G70320
TAIRilocus:2016174, AT1G70320

Phylogenomic databases

eggNOGiKOG0939, Eukaryota
HOGENOMiCLU_000215_1_0_1
InParanoidiQ8H0T4
OMAiLAHATCT
OrthoDBi25515at2759

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8H0T4

Gene expression databases

ExpressionAtlasiQ8H0T4, baseline and differential
GenevisibleiQ8H0T4, AT

Family and domain databases

CDDicd00078, HECTc, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR010309, E3_Ub_ligase_DUF908
IPR010314, E3_Ub_ligase_DUF913
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR025527, HUWE1/Rev1_UBM
IPR015940, UBA
IPR009060, UBA-like_sf
IPR003903, UIM_dom
PfamiView protein in Pfam
PF06012, DUF908, 2 hits
PF06025, DUF913, 1 hit
PF00632, HECT, 1 hit
PF00627, UBA, 1 hit
PF14377, UBM, 3 hits
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SM00165, UBA, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit
SSF48371, SSF48371, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit
PS50030, UBA, 1 hit
PS50330, UIM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUPL2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8H0T4
Secondary accession number(s): O64604
, O64605, Q0WL35, Q9M7K6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 3, 2011
Last modified: September 29, 2021
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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