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UniProtKB - Q8H0B4 (Q8H0B4_NICBE)
Protein
Mitogen-activated protein kinase
Gene
NbWIPK
Organism
Nicotiana benthamiana
Status
Functioni
Catalytic activityi
- EC:2.7.11.24UniRule annotation
Cofactori
Mg2+UniRule annotationARBA annotation
Activity regulationi
Activated by threonine and tyrosine phosphorylation.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 74 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- MAP kinase activity Source: UniProtKB-EC
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine kinase activity Source: RHEA
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotationARBA annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, MagnesiumUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Mitogen-activated protein kinaseUniRule annotationARBA annotation (EC:2.7.11.24UniRule annotationARBA annotation) |
Gene namesi | Name:NbWIPKImported |
Organismi | Nicotiana benthamianaImported |
Taxonomic identifieri | 4100 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 330 | Protein kinaseInterPro annotationAdd BLAST | 287 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.ARBA annotation
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR008352, MAPK_p38-like IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PRINTSi | PR01773, P38MAPKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8H0B4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADANMGGGG GGQFPDFPSV LTHGGQYVQY DIFGNFFEIT TKYRPPIMPI
60 70 80 90 100
GRGAYGIVCS VLNTELNEMV AVKKIANAFD NYMDAKRTLR EIKLLRHLDH
110 120 130 140 150
ENVIGLRDVI PPPLRREFSD VYIATELMDT DLHQIIRSNQ GLSEDHCQYF
160 170 180 190 200
MYQLLRGLKY IHSANVLHRD LKPSNLLLNA NCDLKICDFG LARPNIENEN
210 220 230 240 250
MTEYVVTRWY RAPELLLNSS DYTAAIDVWS VGCIFMELMN RKPLFAGKDH
260 270 280 290 300
VHQIRLLTEL LGTPTEADLG FLQNEDAKRY IRQLPQHPRQ QLANVFPHVN
310 320 330 340 350
PLAIDLVDKM LTLDPTRRIT VEEALDHPYL AKLHDAGDEP ICPVPSSFDF
360 370
EQQGIGEEQI KDMIYQEALS LNPEYA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB098729 mRNA Translation: BAC53771.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB098729 mRNA Translation: BAC53771.1 |
3D structure databases
SMRi | Q8H0B4 |
ModBasei | Search... |
Protein-protein interaction databases
ELMi | Q8H0B4 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR008352, MAPK_p38-like IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PRINTSi | PR01773, P38MAPKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8H0B4_NICBE | |
Accessioni | Q8H0B4Primary (citable) accession number: Q8H0B4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |