Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable threonine--tRNA ligase, cytoplasmic

Gene

At1g17960

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • threonine-tRNA ligase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable threonine--tRNA ligase, cytoplasmic (EC:6.1.1.3)
Alternative name(s):
Threonyl-tRNA synthetase
Short name:
ThrRS
Gene namesi
Ordered Locus Names:At1g17960
ORF Names:F2H15.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G17960
TAIRilocus:2030918 AT1G17960

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001011231 – 458Probable threonine--tRNA ligase, cytoplasmicAdd BLAST458

Proteomic databases

PaxDbiQ8GZ45
PRIDEiQ8GZ45

Expressioni

Gene expression databases

ExpressionAtlasiQ8GZ45 baseline and differential
GenevisibleiQ8GZ45 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G17960.1

Structurei

3D structure databases

ProteinModelPortaliQ8GZ45
SMRiQ8GZ45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1637 Eukaryota
COG0441 LUCA
HOGENOMiHOG000003878
InParanoidiQ8GZ45
KOiK01868
OMAiLARYNYI
OrthoDBiEOG0936135A
PhylomeDBiQ8GZ45

Family and domain databases

Gene3Di3.10.20.30, 1 hit
3.40.50.800, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR012675 Beta-grasp_dom_sf
IPR004095 TGS
IPR012676 TGS-like
IPR002320 Thr-tRNA-ligase_IIa
IPR018163 Thr/Ala-tRNA-synth_IIc_edit
PANTHERiPTHR11451 PTHR11451, 2 hits
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF02824 TGS, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PRINTSiPR01047 TRNASYNTHTHR
SUPFAMiSSF55186 SSF55186, 1 hit
SSF81271 SSF81271, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8GZ45-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANNHHPKDE AYLSSVIPKR IRLFEEIQAE QLEQLQSRPH DPIKITLLPD
60 70 80 90 100
GIEKEGRRWE TSPMDIAVQI SKGLAKSALV SSVNHVLWDM NRPLEGDCSL
110 120 130 140 150
EIFGFDSDQG RNTFWHSSAH ILGQALEQEY GCKLCIGPCE PRDEGFYYDS
160 170 180 190 200
LYYGELGLND NHFPNIEAKL PIRMAEFGVL HRNEDSGALG GMTRVRRFVQ
210 220 230 240 250
DDAHIFCRVD QVEEEVKGVL DFIDYVYRIF GFTYELTLST RPKDHIGDLE
260 270 280 290 300
TWAKAENDLE KALDDFGKPW VIKEGDGAFY GPKIDITVSD ARNRKFQCAT
310 320 330 340 350
IQLDFQLPAC FKLKYLSEKN EMEAPVMIHS AVLGSIERMF AILLEHYKGI
360 370 380 390 400
WPFWLSPRQA IVCSLSEDCS SYAKQVQKQI NEVGYYVDID ESDRSLRKKV
410 420 430 440 450
ADARDAPYNY ILVVGQKEVA TGQVTVRLRE DPEGRKDLPE MSIESLLDEF

KFKTVNFL
Length:458
Mass (Da):52,436
Last modified:January 24, 2006 - v2
Checksum:iBBFBC833E5AE0608
GO
Isoform 2 (identifier: Q8GZ45-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-186: KLPIRMAEFGVLHRNEDS → SVAYISFADIFFVLRYGM
     187-458: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:186
Mass (Da):21,211
Checksum:i8CA4DBDD4EF3E120
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8AVU9A0A1P8AVU9_ARATH
Threonyl-tRNA synthetase
At1g17960, F2H15.18, F2H15_18
385Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017125169 – 186KLPIR…RNEDS → SVAYISFADIFFVLRYGM in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_017126187 – 458Missing in isoform 2. 1 PublicationAdd BLAST272

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034106 Genomic DNA Translation: AAF97275.1
CP002684 Genomic DNA Translation: AEE29656.1
AK117218 mRNA Translation: BAC41894.1
PIRiH86314
RefSeqiNP_173238.1, NM_101659.3 [Q8GZ45-1]
UniGeneiAt.41808

Genome annotation databases

EnsemblPlantsiAT1G17960.1; AT1G17960.1; AT1G17960 [Q8GZ45-1]
GeneIDi838375
GrameneiAT1G17960.1; AT1G17960.1; AT1G17960 [Q8GZ45-1]
KEGGiath:AT1G17960

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034106 Genomic DNA Translation: AAF97275.1
CP002684 Genomic DNA Translation: AEE29656.1
AK117218 mRNA Translation: BAC41894.1
PIRiH86314
RefSeqiNP_173238.1, NM_101659.3 [Q8GZ45-1]
UniGeneiAt.41808

3D structure databases

ProteinModelPortaliQ8GZ45
SMRiQ8GZ45
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G17960.1

Proteomic databases

PaxDbiQ8GZ45
PRIDEiQ8GZ45

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G17960.1; AT1G17960.1; AT1G17960 [Q8GZ45-1]
GeneIDi838375
GrameneiAT1G17960.1; AT1G17960.1; AT1G17960 [Q8GZ45-1]
KEGGiath:AT1G17960

Organism-specific databases

AraportiAT1G17960
TAIRilocus:2030918 AT1G17960

Phylogenomic databases

eggNOGiKOG1637 Eukaryota
COG0441 LUCA
HOGENOMiHOG000003878
InParanoidiQ8GZ45
KOiK01868
OMAiLARYNYI
OrthoDBiEOG0936135A
PhylomeDBiQ8GZ45

Miscellaneous databases

PROiPR:Q8GZ45

Gene expression databases

ExpressionAtlasiQ8GZ45 baseline and differential
GenevisibleiQ8GZ45 AT

Family and domain databases

Gene3Di3.10.20.30, 1 hit
3.40.50.800, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR012675 Beta-grasp_dom_sf
IPR004095 TGS
IPR012676 TGS-like
IPR002320 Thr-tRNA-ligase_IIa
IPR018163 Thr/Ala-tRNA-synth_IIc_edit
PANTHERiPTHR11451 PTHR11451, 2 hits
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF02824 TGS, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PRINTSiPR01047 TRNASYNTHTHR
SUPFAMiSSF55186 SSF55186, 1 hit
SSF81271 SSF81271, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYTC_ARATH
AccessioniPrimary (citable) accession number: Q8GZ45
Secondary accession number(s): Q9LMT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again