UniProtKB - Q8GXR9 (NDC1_ARATH)
Alternative NAD(P)H-ubiquinone oxidoreductase C1, chloroplastic/mitochondrial
NDC1
Functioni
Bifunctional oxidoreductase ables to act both on prenyl naphthoquinones and on prenyl benzoquinones (PubMed:21844348, PubMed:26023160).
May serve a respiratory function (PubMed:12972666).
Involved in an electron flow toward the plastoglobule plastoquinone pool (PubMed:21844348, PubMed:25018761).
Required for plastochromanol-8 accumulation and for phylloquinone (vitamin K1) production (PubMed:21844348, PubMed:25018761).
Probably not directly involved in cyclic or chlororespiratory electron flows under standard growth conditions, but participates in the redox metabolism of plastoquinone-9 and the tocophrol recycling-intermediate alpha-tocopherol quinone (PubMed:21844348, PubMed:25018761).
Catalyzes the penultimate step in the biosynthesis of vitamin K1 (PubMed:26023160).
4 PublicationsCatalytic activityi
Cofactori
Activity regulationi
Kineticsi
- KM=9 µM for decyl-plastoquinone1 Publication
- KM=20 µM for menadione1 Publication
- Vmax=46 µmol/min/mg enzyme toward decyl-plastoquinone1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 82 – 118 | FADBy similarityAdd BLAST | 37 | |
Nucleotide bindingi | 246 – 282 | NADBy similarityAdd BLAST | 37 |
GO - Molecular functioni
- NAD(P)H dehydrogenase (quinone) activity Source: GO_Central
- NADH dehydrogenase (quinone) activity Source: RHEA
- oxidoreductase activity Source: UniProtKB
GO - Biological processi
- aerobic electron transport chain Source: GO_Central
- cellular response to light stimulus Source: UniProtKB
- phylloquinone biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein, NAD, NADP |
Enzyme and pathway databases
BioCyci | ARA:AT5G08740-MONOMER |
BRENDAi | 1.6.5.12, 399 |
SABIO-RKi | Q8GXR9 |
Chemistry databases
SwissLipidsi | SLP:000001504 |
Names & Taxonomyi
Protein namesi | Recommended name: Alternative NAD(P)H-ubiquinone oxidoreductase C1, chloroplastic/mitochondrial1 Publication (EC:1.6.5.91 Publication)Alternative name(s): Alternative NADH dehydrogenase NDC11 Publication Demethylphylloquinone reductase NDC11 Publication (EC:1.6.5.122 Publications) NADH:ubiquinone reductase (non-electrogenic) NDC11 Publication |
Gene namesi | Name:NDC11 Publication Ordered Locus Names:At5g08740Imported ORF Names:T2K12.12Imported, T2K12_90 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G08740 |
Subcellular locationi
Mitochondrion
- Mitochondrion 4 Publications
- Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication
Chloroplast
- chloroplast 3 Publications
- plastoglobule 4 Publications
Chloroplast
- chloroplast Source: UniProtKB
- plastoglobule Source: UniProtKB
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
Chloroplast, Membrane, Mitochondrion, Mitochondrion inner membrane, PlastidPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 52 | Chloroplast and mitochondrionSequence analysisAdd BLAST | 52 | |
ChainiPRO_0000286517 | 53 – 519 | Alternative NAD(P)H-ubiquinone oxidoreductase C1, chloroplastic/mitochondrialAdd BLAST | 467 |
Proteomic databases
PaxDbi | Q8GXR9 |
PeptideAtlasi | Q8GXR9 |
PRIDEi | Q8GXR9 |
ProteomicsDBi | 236812 [Q8GXR9-1] |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
ExpressionAtlasi | Q8GXR9, baseline and differential |
Genevisiblei | Q8GXR9, AT |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2495, Eukaryota |
HOGENOMi | CLU_021377_2_0_1 |
InParanoidi | Q8GXR9 |
OrthoDBi | 1463391at2759 |
PhylomeDBi | Q8GXR9 |
Family and domain databases
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVLSSVSSL IPFSYGATRL TSKASLASRT SGFNLSSRWN STRNSPMLYL
60 70 80 90 100
SRAVTNNSGT TEISDNETAP RTYSWPDNKR PRVCILGGGF GGLYTALRLE
110 120 130 140 150
SLVWPEDKKP QVVLVDQSER FVFKPMLYEL LSGEVDVWEI APRFSDLLTN
160 170 180 190 200
TGIQFLRDRV KTLLPCDHLG VNGSEISVTG GTVLLESGFK IEYDWLVLAL
210 220 230 240 250
GAESKLDVVP GAMELAFPFY TLEDAIRVNE KLSKLERKNF KDGSAIKVAV
260 270 280 290 300
VGCGYAGVEL AATISERLQD RGIVQSINVS KNILTSAPDG NREAAMKVLT
310 320 330 340 350
SRKVQLLLGY LVQSIKRASN LEEDEGYFLE LQPAERGLES QIIEADIVLW
360 370 380 390 400
TVGAKPLLTK LEPSGPNVLP LNARGQAETD ETLRVKGHPR IFALGDSSSL
410 420 430 440 450
RDSNGKILPT TAQVAFQEAD FTGWNIWAAI NNRPLLPFRF QNLGEMMTLG
460 470 480 490 500
RYDAAISPSF IEGLTLEGPI GHAARKLAYL IRLPTDEHRF KVGISWFAKS
510
AVDSIALLQS NLTKVLSGS
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 404 | N → H in BAC42708 (PubMed:11910074).Curated | 1 | |
Sequence conflicti | 487 – 497 | EHRFKVGISWF → QHLFMVRISCL in CAC35879 (PubMed:11130714).CuratedAdd BLAST | 11 | |
Sequence conflicti | 491 – 493 | KVG → MVR in AED91343 (PubMed:27862469).Curated | 3 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025063 | 1 – 170 | Missing in isoform 2. 1 PublicationAdd BLAST | 170 | |
Alternative sequenceiVSP_025064 | 171 – 195 | VNGSE…IEYDW → MGLRFLLLEEPSCSKAVLKS NTIAR in isoform 2. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_025065 | 415 – 427 | AFQEA…GWNIW → RKKATKYEHIHVL in isoform 2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_025066 | 428 – 519 | Missing in isoform 2. 1 PublicationAdd BLAST | 92 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590346 Genomic DNA Translation: CAC35879.1 Sequence problems. CP002688 Genomic DNA Translation: AED91343.1 AK118078 mRNA Translation: BAC42708.1 Sequence problems. AY056424 mRNA Translation: AAL08280.1 AY127949 mRNA Translation: AAM91048.1 AJ715502 Genomic DNA Translation: CAG29362.1 |
RefSeqi | NP_568205.6, NM_120955.8 |
Genome annotation databases
GeneIDi | 830775 |
KEGGi | ath:AT5G08740 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590346 Genomic DNA Translation: CAC35879.1 Sequence problems. CP002688 Genomic DNA Translation: AED91343.1 AK118078 mRNA Translation: BAC42708.1 Sequence problems. AY056424 mRNA Translation: AAL08280.1 AY127949 mRNA Translation: AAM91048.1 AJ715502 Genomic DNA Translation: CAG29362.1 |
RefSeqi | NP_568205.6, NM_120955.8 |
3D structure databases
AlphaFoldDBi | Q8GXR9 |
SMRi | Q8GXR9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT5G08740.1 |
Chemistry databases
SwissLipidsi | SLP:000001504 |
Proteomic databases
PaxDbi | Q8GXR9 |
PeptideAtlasi | Q8GXR9 |
PRIDEi | Q8GXR9 |
ProteomicsDBi | 236812 [Q8GXR9-1] |
Genome annotation databases
GeneIDi | 830775 |
KEGGi | ath:AT5G08740 |
Organism-specific databases
Araporti | AT5G08740 |
Phylogenomic databases
eggNOGi | KOG2495, Eukaryota |
HOGENOMi | CLU_021377_2_0_1 |
InParanoidi | Q8GXR9 |
OrthoDBi | 1463391at2759 |
PhylomeDBi | Q8GXR9 |
Enzyme and pathway databases
BioCyci | ARA:AT5G08740-MONOMER |
BRENDAi | 1.6.5.12, 399 |
SABIO-RKi | Q8GXR9 |
Miscellaneous databases
PROi | PR:Q8GXR9 |
Gene expression databases
ExpressionAtlasi | Q8GXR9, baseline and differential |
Genevisiblei | Q8GXR9, AT |
Family and domain databases
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NDC1_ARATH | |
Accessioni | Q8GXR9Primary (citable) accession number: Q8GXR9 Secondary accession number(s): F4KCG9 Q9C5A3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | May 15, 2007 | |
Last modified: | May 25, 2022 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families