UniProtKB - Q8GXJ4 (GLR34_ARATH)
Glutamate receptor 3.4
GLR3.4
Functioni
Glutamate-gated receptor that probably acts as non-selective cation channel, at least in hypocotyls (Probable). Can be triggered by Asn, Ser, Gly and, to a lower extent, Ala, Cys and Glu (PubMed:18162597, PubMed:22447719).
May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells (Probable). Plays an important role in the calcium-based fast transmission of environmental stress (PubMed:15864638).
Acts as negative regulator of lateral root initiation and development (PubMed:23590882).
May restrict primordia numbers and position along the root axis by a signaling process originating in the phloem (PubMed:23590882).
AtGLR3.4-mediated cytosolic calcium influx may be involved in the regulation of seed germination under salt stress by modulating sodium accumulation through the SOS pathway (PubMed:29432559).
2 Publications5 PublicationsGO - Molecular functioni
- calcium channel activity Source: UniProtKB
- glutamate receptor activity Source: UniProtKB
- ligand-gated ion channel activity Source: TAIR
- signaling receptor activity Source: GO_Central
GO - Biological processi
- calcium ion transport Source: TAIR
- calcium-mediated signaling Source: UniProtKB
- cellular response to acetate Source: UniProtKB
- cellular response to amino acid stimulus Source: UniProtKB
- cellular response to cold Source: UniProtKB
- cellular response to mechanical stimulus Source: UniProtKB
- response to wounding Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Stress response, Transport |
Protein family/group databases
TCDBi | 1.A.10.1.10, the glutamate-gated ion channel (gic) family of neurotransmitter receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate receptor 3.41 PublicationShort name: AtGLR3.41 Publication Alternative name(s): Glutamate receptor-like protein 3.41 Publication Ligand-gated ion channel 3.4Curated |
Gene namesi | Name:GLR3.41 Publication Synonyms:GLR4Curated, GLUR31 Publication Ordered Locus Names:At1g05200Imported ORF Names:YUP8H12.19Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G05200 |
TAIRi | locus:2207165, AT1G05200 |
Subcellular locationi
Plasma membrane
- Cell membrane 4 Publications; Multi-pass membrane protein Sequence analysis
Chloroplast
- chloroplast membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Localizes to the plasma membrane.4 Publications
Chloroplast
- chloroplast Source: UniProtKB
- chloroplast membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- plastid Source: TAIR
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 36 – 613 | ExtracellularSequence analysisAdd BLAST | 578 | |
Transmembranei | 614 – 634 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 635 – 643 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 644 – 664 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 665 – 675 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 676 – 696 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 697 – 857 | ExtracellularSequence analysisAdd BLAST | 161 | |
Transmembranei | 858 – 878 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 879 – 959 | CytoplasmicSequence analysisAdd BLAST | 81 |
Keywords - Cellular componenti
Cell membrane, Chloroplast, Membrane, PlastidPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 35 | Sequence analysisAdd BLAST | 35 | |
ChainiPRO_0000011608 | 36 – 959 | Glutamate receptor 3.4Add BLAST | 924 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 42 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 108 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 365 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 378 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 404 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 443 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 461 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 576 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q8GXJ4 |
PRIDEi | Q8GXJ4 |
ProteomicsDBi | 248596 [Q8GXJ4-1] |
PTM databases
iPTMneti | Q8GXJ4 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
ExpressionAtlasi | Q8GXJ4, baseline and differential |
Genevisiblei | Q8GXJ4, AT |
Interactioni
Subunit structurei
Forms a heteromeric channel with GLR3.2.
1 PublicationProtein-protein interaction databases
BioGRIDi | 24503, 22 interactors |
IntActi | Q8GXJ4, 12 interactors |
STRINGi | 3702.AT1G05200.2 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q8GXJ4 |
SMRi | Q8GXJ4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 893 – 913 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 936 – 959 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 939 – 959 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1052, Eukaryota |
HOGENOMi | CLU_007358_0_1_1 |
InParanoidi | Q8GXJ4 |
OMAi | EREQVFV |
PhylomeDBi | Q8GXJ4 |
Family and domain databases
CDDi | cd19990, PBP1_GABAb_receptor_plant, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR044440, GABAb_receptor_plant_PBP1 IPR001320, Iontro_rcpt IPR017103, Iontropic_Glu_rcpt_pln IPR028082, Peripla_BP_I IPR001638, Solute-binding_3/MltF_N |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF00497, SBP_bac_3, 1 hit |
PIRSFi | PIRSF037090, Iontro_Glu-like_rcpt_pln, 1 hit |
SMARTi | View protein in SMART SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGFLVMIREV SMAKAIRVVL LCVSVLWVVP KECACRSNFS RNSSSSSSSS
60 70 80 90 100
LRPLRQRPSS VNVGALFTYD SFIGRAAKPA VKAAMDDVNA DQSVLKGIKL
110 120 130 140 150
NIIFQDSNCS GFIGTMGALQ LMENKVVAAI GPQSSGIAHM ISYVANELHV
160 170 180 190 200
PLLSFGATDP TLSSLQFPYF LRTTQNDYFQ MHAIADFLSY SGWRQVIAIF
210 220 230 240 250
VDDECGRNGI SVLGDVLAKK RSRISYKAAI TPGADSSSIR DLLVSVNLME
260 270 280 290 300
SRVFVVHVNP DSGLNVFSVA KSLGMMASGY VWIATDWLPT AMDSMEHVDS
310 320 330 340 350
DTMDLLQGVV AFRHYTIESS VKRQFMARWK NLRPNDGFNS YAMYAYDSVW
360 370 380 390 400
LVARALDVFF RENNNITFSN DPNLHKTNGS TIQLSALSVF NEGEKFMKII
410 420 430 440 450
LGMNHTGVTG PIQFDSDRNR VNPAYEVLNL EGTAPRTVGY WSNHSGLSVV
460 470 480 490 500
HPETLYSRPP NTSTANQRLK GIIYPGEVTK PPRGWVFPNN GKPLRIGVPN
510 520 530 540 550
RVSYTDYVSK DKNPPGVRGY CIDVFEAAIE LLPYPVPRTY ILYGDGKRNP
560 570 580 590 600
SYDNLVNEVV ADNFDVAVGD ITIVTNRTRY VDFTQPFIES GLVVVAPVKE
610 620 630 640 650
AKSSPWSFLK PFTIEMWAVT GGFFLFVGAM VWILEHRFNQ EFRGPPRRQL
660 670 680 690 700
ITIFWFSFST MFFSHRENTV SSLGRFVLII WLFVVLIINS SYTASLTSIL
710 720 730 740 750
TIRQLTSRIE GIDSLVTSNE PIGVQDGTFA RNYLINELNI LPSRIVPLKD
760 770 780 790 800
EEQYLSALQR GPNAGGVAAI VDELPYIEVL LTNSNCKFRT VGQEFTRTGW
810 820 830 840 850
GFAFQRDSPL AVDMSTAILQ LSEEGELEKI HRKWLNYKHE CSMQISNSED
860 870 880 890 900
SQLSLKSFWG LFLICGITCF MALTVFFWRV FWQYQRLLPE SADEERAGEV
910 920 930 940 950
SEPSRSGRGS RAPSFKELIK VVDKREAEIK EILKQKSSKK LKSTQSAAGT
SQSQHGEIT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8AP10 | A0A1P8AP10_ARATH | Glutamate receptor | GLR3.4 ATGLR3.4, GLUR3, glutamate receptor 3.4, YUP8H12.19, YUP8H12_19 | 828 | Annotation score: | ||
A0A1P8AP36 | A0A1P8AP36_ARATH | Glutamate receptor 3.4 | GLR3.4 ATGLR3.4, GLUR3, glutamate receptor 3.4, YUP8H12.19, YUP8H12_19 | 675 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 | R → G in AAD47833 (PubMed:15864638).Curated | 1 | |
Sequence conflicti | 152 | L → P in AAD47833 (PubMed:15864638).Curated | 1 | |
Sequence conflicti | 444 | H → Q in AAD47833 (PubMed:15864638).Curated | 1 | |
Sequence conflicti | 450 | V → A in BAC42828 (PubMed:11910074).Curated | 1 | |
Sequence conflicti | 733 | Y → N in AAD47833 (PubMed:15864638).Curated | 1 | |
Sequence conflicti | 897 | A → P in AAD47833 (PubMed:15864638).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009219 | 656 – 669 | FSFST…HRENT → LVSQFLTLEPEFTF in isoform 2. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_009220 | 670 – 959 | Missing in isoform 2. 1 PublicationAdd BLAST | 290 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY072070 mRNA Translation: AAL61999.1 AC000098 Genomic DNA Translation: AAB71458.1 Sequence problems. CP002684 Genomic DNA Translation: AEE27803.1 CP002684 Genomic DNA Translation: AEE27804.1 CP002684 Genomic DNA Translation: ANM58387.1 CP002684 Genomic DNA Translation: ANM58390.1 AK118206 mRNA Translation: BAC42828.1 AF167355 mRNA Translation: AAD47833.1 Sequence problems. |
PIRi | D86186 T51135 |
RefSeqi | NP_001030971.1, NM_001035894.1 [Q8GXJ4-1] NP_001320828.1, NM_001331525.1 [Q8GXJ4-2] NP_001320831.1, NM_001331526.1 [Q8GXJ4-1] NP_172012.2, NM_100398.3 [Q8GXJ4-1] |
Genome annotation databases
EnsemblPlantsi | AT1G05200.1; AT1G05200.1; AT1G05200 [Q8GXJ4-1] AT1G05200.2; AT1G05200.2; AT1G05200 [Q8GXJ4-1] AT1G05200.5; AT1G05200.5; AT1G05200 [Q8GXJ4-2] AT1G05200.6; AT1G05200.6; AT1G05200 [Q8GXJ4-1] |
GeneIDi | 839268 |
Gramenei | AT1G05200.1; AT1G05200.1; AT1G05200 [Q8GXJ4-1] AT1G05200.2; AT1G05200.2; AT1G05200 [Q8GXJ4-1] AT1G05200.5; AT1G05200.5; AT1G05200 [Q8GXJ4-2] AT1G05200.6; AT1G05200.6; AT1G05200 [Q8GXJ4-1] |
KEGGi | ath:AT1G05200 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY072070 mRNA Translation: AAL61999.1 AC000098 Genomic DNA Translation: AAB71458.1 Sequence problems. CP002684 Genomic DNA Translation: AEE27803.1 CP002684 Genomic DNA Translation: AEE27804.1 CP002684 Genomic DNA Translation: ANM58387.1 CP002684 Genomic DNA Translation: ANM58390.1 AK118206 mRNA Translation: BAC42828.1 AF167355 mRNA Translation: AAD47833.1 Sequence problems. |
PIRi | D86186 T51135 |
RefSeqi | NP_001030971.1, NM_001035894.1 [Q8GXJ4-1] NP_001320828.1, NM_001331525.1 [Q8GXJ4-2] NP_001320831.1, NM_001331526.1 [Q8GXJ4-1] NP_172012.2, NM_100398.3 [Q8GXJ4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7LZ0 | X-ray | 2.29 | A/B/C | 492-601 | [»] | |
A/B/C | 709-842 | [»] | ||||
7LZ1 | X-ray | 1.51 | A/B/C | 492-601 | [»] | |
A/B/C | 709-842 | [»] | ||||
7LZ2 | X-ray | 1.50 | A/B/C | 492-601 | [»] | |
A/B/C | 709-842 | [»] | ||||
7LZH | electron microscopy | 3.57 | A/B/C/D | 1-959 | [»] | |
7LZI | electron microscopy | 4.39 | A/B/C/D | 1-959 | [»] | |
AlphaFoldDBi | Q8GXJ4 | |||||
SMRi | Q8GXJ4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 24503, 22 interactors |
IntActi | Q8GXJ4, 12 interactors |
STRINGi | 3702.AT1G05200.2 |
Protein family/group databases
TCDBi | 1.A.10.1.10, the glutamate-gated ion channel (gic) family of neurotransmitter receptors |
PTM databases
iPTMneti | Q8GXJ4 |
Proteomic databases
PaxDbi | Q8GXJ4 |
PRIDEi | Q8GXJ4 |
ProteomicsDBi | 248596 [Q8GXJ4-1] |
Genome annotation databases
EnsemblPlantsi | AT1G05200.1; AT1G05200.1; AT1G05200 [Q8GXJ4-1] AT1G05200.2; AT1G05200.2; AT1G05200 [Q8GXJ4-1] AT1G05200.5; AT1G05200.5; AT1G05200 [Q8GXJ4-2] AT1G05200.6; AT1G05200.6; AT1G05200 [Q8GXJ4-1] |
GeneIDi | 839268 |
Gramenei | AT1G05200.1; AT1G05200.1; AT1G05200 [Q8GXJ4-1] AT1G05200.2; AT1G05200.2; AT1G05200 [Q8GXJ4-1] AT1G05200.5; AT1G05200.5; AT1G05200 [Q8GXJ4-2] AT1G05200.6; AT1G05200.6; AT1G05200 [Q8GXJ4-1] |
KEGGi | ath:AT1G05200 |
Organism-specific databases
Araporti | AT1G05200 |
TAIRi | locus:2207165, AT1G05200 |
Phylogenomic databases
eggNOGi | KOG1052, Eukaryota |
HOGENOMi | CLU_007358_0_1_1 |
InParanoidi | Q8GXJ4 |
OMAi | EREQVFV |
PhylomeDBi | Q8GXJ4 |
Miscellaneous databases
PROi | PR:Q8GXJ4 |
Gene expression databases
ExpressionAtlasi | Q8GXJ4, baseline and differential |
Genevisiblei | Q8GXJ4, AT |
Family and domain databases
CDDi | cd19990, PBP1_GABAb_receptor_plant, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR044440, GABAb_receptor_plant_PBP1 IPR001320, Iontro_rcpt IPR017103, Iontropic_Glu_rcpt_pln IPR028082, Peripla_BP_I IPR001638, Solute-binding_3/MltF_N |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF00497, SBP_bac_3, 1 hit |
PIRSFi | PIRSF037090, Iontro_Glu-like_rcpt_pln, 1 hit |
SMARTi | View protein in SMART SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GLR34_ARATH | |
Accessioni | Q8GXJ4Primary (citable) accession number: Q8GXJ4 Secondary accession number(s): O23048, Q8LGM9, Q9SWD9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | January 16, 2004 | |
Last modified: | May 25, 2022 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families