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Entry version 150 (25 May 2022)
Sequence version 2 (16 Jan 2004)
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Protein

Glutamate receptor 3.4

Gene

GLR3.4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glutamate-gated receptor that probably acts as non-selective cation channel, at least in hypocotyls (Probable). Can be triggered by Asn, Ser, Gly and, to a lower extent, Ala, Cys and Glu (PubMed:18162597, PubMed:22447719).

May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells (Probable). Plays an important role in the calcium-based fast transmission of environmental stress (PubMed:15864638).

Acts as negative regulator of lateral root initiation and development (PubMed:23590882).

May restrict primordia numbers and position along the root axis by a signaling process originating in the phloem (PubMed:23590882).

AtGLR3.4-mediated cytosolic calcium influx may be involved in the regulation of seed germination under salt stress by modulating sodium accumulation through the SOS pathway (PubMed:29432559).

2 Publications5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Stress response, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.10.1.10, the glutamate-gated ion channel (gic) family of neurotransmitter receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamate receptor 3.41 Publication
Short name:
AtGLR3.41 Publication
Alternative name(s):
Glutamate receptor-like protein 3.41 Publication
Ligand-gated ion channel 3.4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLR3.41 Publication
Synonyms:GLR4Curated, GLUR31 Publication
Ordered Locus Names:At1g05200Imported
ORF Names:YUP8H12.19Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G05200

The Arabidopsis Information Resource

More...
TAIRi
locus:2207165, AT1G05200

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 613ExtracellularSequence analysisAdd BLAST578
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei614 – 634HelicalSequence analysisAdd BLAST21
Topological domaini635 – 643CytoplasmicSequence analysis9
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 675CytoplasmicSequence analysisAdd BLAST11
Transmembranei676 – 696HelicalSequence analysisAdd BLAST21
Topological domaini697 – 857ExtracellularSequence analysisAdd BLAST161
Transmembranei858 – 878HelicalSequence analysisAdd BLAST21
Topological domaini879 – 959CytoplasmicSequence analysisAdd BLAST81

Keywords - Cellular componenti

Cell membrane, Chloroplast, Membrane, Plastid

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impaired glutamate-triggered (and Ala, Asn, Cys, Gly, Ser-triggered) membrane depolarization and calcium rise (PubMed:18162597). Slight reduction of photosynthetic yield of Photosystem II (PubMed:21110940). Overproduction and aberrant placement of lateral root primordia (PubMed:23590882).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001160836 – 959Glutamate receptor 3.4Add BLAST924

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi404N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi576N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8GXJ4

PRoteomics IDEntifications database

More...
PRIDEi
Q8GXJ4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
248596 [Q8GXJ4-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8GXJ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in roots and at lower levels in leaves and siliques (PubMed:12082126). Expressed in seedlings, cotyledons, roots (e.g. root hairs, epidermis and cortex cells), stems, leaves (e.g. vascular bundles and hydathodes), and siliques (PubMed:15864638). Expressed in root phloem (PubMed:23590882).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

The induction by glutamate, gamma-amino butiric acid (GABA), malate, aspartate, acetate, wounding, touch, and cold stress stimuli is abscisic acid (ABA)-independent, but calcium-dependent. Cold-mediated induction is rapid but transient.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8GXJ4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8GXJ4, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heteromeric channel with GLR3.2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
24503, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q8GXJ4, 12 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G05200.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1959
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q8GXJ4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8GXJ4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni893 – 913DisorderedSequence analysisAdd BLAST21
Regioni936 – 959DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi939 – 959Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1052, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007358_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8GXJ4

Identification of Orthologs from Complete Genome Data

More...
OMAi
EREQVFV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8GXJ4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd19990, PBP1_GABAb_receptor_plant, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR044440, GABAb_receptor_plant_PBP1
IPR001320, Iontro_rcpt
IPR017103, Iontropic_Glu_rcpt_pln
IPR028082, Peripla_BP_I
IPR001638, Solute-binding_3/MltF_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01094, ANF_receptor, 1 hit
PF00060, Lig_chan, 1 hit
PF00497, SBP_bac_3, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037090, Iontro_Glu-like_rcpt_pln, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00079, PBPe, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822, SSF53822, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8GXJ4-1) [UniParc]FASTAAdd to basket
Also known as: GLR3.4a

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFLVMIREV SMAKAIRVVL LCVSVLWVVP KECACRSNFS RNSSSSSSSS
60 70 80 90 100
LRPLRQRPSS VNVGALFTYD SFIGRAAKPA VKAAMDDVNA DQSVLKGIKL
110 120 130 140 150
NIIFQDSNCS GFIGTMGALQ LMENKVVAAI GPQSSGIAHM ISYVANELHV
160 170 180 190 200
PLLSFGATDP TLSSLQFPYF LRTTQNDYFQ MHAIADFLSY SGWRQVIAIF
210 220 230 240 250
VDDECGRNGI SVLGDVLAKK RSRISYKAAI TPGADSSSIR DLLVSVNLME
260 270 280 290 300
SRVFVVHVNP DSGLNVFSVA KSLGMMASGY VWIATDWLPT AMDSMEHVDS
310 320 330 340 350
DTMDLLQGVV AFRHYTIESS VKRQFMARWK NLRPNDGFNS YAMYAYDSVW
360 370 380 390 400
LVARALDVFF RENNNITFSN DPNLHKTNGS TIQLSALSVF NEGEKFMKII
410 420 430 440 450
LGMNHTGVTG PIQFDSDRNR VNPAYEVLNL EGTAPRTVGY WSNHSGLSVV
460 470 480 490 500
HPETLYSRPP NTSTANQRLK GIIYPGEVTK PPRGWVFPNN GKPLRIGVPN
510 520 530 540 550
RVSYTDYVSK DKNPPGVRGY CIDVFEAAIE LLPYPVPRTY ILYGDGKRNP
560 570 580 590 600
SYDNLVNEVV ADNFDVAVGD ITIVTNRTRY VDFTQPFIES GLVVVAPVKE
610 620 630 640 650
AKSSPWSFLK PFTIEMWAVT GGFFLFVGAM VWILEHRFNQ EFRGPPRRQL
660 670 680 690 700
ITIFWFSFST MFFSHRENTV SSLGRFVLII WLFVVLIINS SYTASLTSIL
710 720 730 740 750
TIRQLTSRIE GIDSLVTSNE PIGVQDGTFA RNYLINELNI LPSRIVPLKD
760 770 780 790 800
EEQYLSALQR GPNAGGVAAI VDELPYIEVL LTNSNCKFRT VGQEFTRTGW
810 820 830 840 850
GFAFQRDSPL AVDMSTAILQ LSEEGELEKI HRKWLNYKHE CSMQISNSED
860 870 880 890 900
SQLSLKSFWG LFLICGITCF MALTVFFWRV FWQYQRLLPE SADEERAGEV
910 920 930 940 950
SEPSRSGRGS RAPSFKELIK VVDKREAEIK EILKQKSSKK LKSTQSAAGT

SQSQHGEIT
Length:959
Mass (Da):107,207
Last modified:January 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0709B834A76FAFC0
GO
Isoform 2 (identifier: Q8GXJ4-2) [UniParc]FASTAAdd to basket
Also known as: GLR3.4b

The sequence of this isoform differs from the canonical sequence as follows:
     656-669: FSFSTMFFSHRENT → LVSQFLTLEPEFTF
     670-959: Missing.

Note: May be due to an intron retention.Curated
Show »
Length:669
Mass (Da):74,551
Checksum:i623551179F90EBFD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8AP10A0A1P8AP10_ARATH
Glutamate receptor
GLR3.4 ATGLR3.4, GLUR3, glutamate receptor 3.4, YUP8H12.19, YUP8H12_19
828Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1P8AP36A0A1P8AP36_ARATH
Glutamate receptor 3.4
GLR3.4 ATGLR3.4, GLUR3, glutamate receptor 3.4, YUP8H12.19, YUP8H12_19
675Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB71458 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAD47833 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57R → G in AAD47833 (PubMed:15864638).Curated1
Sequence conflicti152L → P in AAD47833 (PubMed:15864638).Curated1
Sequence conflicti444H → Q in AAD47833 (PubMed:15864638).Curated1
Sequence conflicti450V → A in BAC42828 (PubMed:11910074).Curated1
Sequence conflicti733Y → N in AAD47833 (PubMed:15864638).Curated1
Sequence conflicti897A → P in AAD47833 (PubMed:15864638).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009219656 – 669FSFST…HRENT → LVSQFLTLEPEFTF in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_009220670 – 959Missing in isoform 2. 1 PublicationAdd BLAST290

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY072070 mRNA Translation: AAL61999.1
AC000098 Genomic DNA Translation: AAB71458.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE27803.1
CP002684 Genomic DNA Translation: AEE27804.1
CP002684 Genomic DNA Translation: ANM58387.1
CP002684 Genomic DNA Translation: ANM58390.1
AK118206 mRNA Translation: BAC42828.1
AF167355 mRNA Translation: AAD47833.1 Sequence problems.

Protein sequence database of the Protein Information Resource

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PIRi
D86186
T51135

NCBI Reference Sequences

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RefSeqi
NP_001030971.1, NM_001035894.1 [Q8GXJ4-1]
NP_001320828.1, NM_001331525.1 [Q8GXJ4-2]
NP_001320831.1, NM_001331526.1 [Q8GXJ4-1]
NP_172012.2, NM_100398.3 [Q8GXJ4-1]

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT1G05200.1; AT1G05200.1; AT1G05200 [Q8GXJ4-1]
AT1G05200.2; AT1G05200.2; AT1G05200 [Q8GXJ4-1]
AT1G05200.5; AT1G05200.5; AT1G05200 [Q8GXJ4-2]
AT1G05200.6; AT1G05200.6; AT1G05200 [Q8GXJ4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
839268

Gramene; a comparative resource for plants

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Gramenei
AT1G05200.1; AT1G05200.1; AT1G05200 [Q8GXJ4-1]
AT1G05200.2; AT1G05200.2; AT1G05200 [Q8GXJ4-1]
AT1G05200.5; AT1G05200.5; AT1G05200 [Q8GXJ4-2]
AT1G05200.6; AT1G05200.6; AT1G05200 [Q8GXJ4-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT1G05200

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072070 mRNA Translation: AAL61999.1
AC000098 Genomic DNA Translation: AAB71458.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE27803.1
CP002684 Genomic DNA Translation: AEE27804.1
CP002684 Genomic DNA Translation: ANM58387.1
CP002684 Genomic DNA Translation: ANM58390.1
AK118206 mRNA Translation: BAC42828.1
AF167355 mRNA Translation: AAD47833.1 Sequence problems.
PIRiD86186
T51135
RefSeqiNP_001030971.1, NM_001035894.1 [Q8GXJ4-1]
NP_001320828.1, NM_001331525.1 [Q8GXJ4-2]
NP_001320831.1, NM_001331526.1 [Q8GXJ4-1]
NP_172012.2, NM_100398.3 [Q8GXJ4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7LZ0X-ray2.29A/B/C492-601[»]
A/B/C709-842[»]
7LZ1X-ray1.51A/B/C492-601[»]
A/B/C709-842[»]
7LZ2X-ray1.50A/B/C492-601[»]
A/B/C709-842[»]
7LZHelectron microscopy3.57A/B/C/D1-959[»]
7LZIelectron microscopy4.39A/B/C/D1-959[»]
AlphaFoldDBiQ8GXJ4
SMRiQ8GXJ4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi24503, 22 interactors
IntActiQ8GXJ4, 12 interactors
STRINGi3702.AT1G05200.2

Protein family/group databases

TCDBi1.A.10.1.10, the glutamate-gated ion channel (gic) family of neurotransmitter receptors

PTM databases

iPTMnetiQ8GXJ4

Proteomic databases

PaxDbiQ8GXJ4
PRIDEiQ8GXJ4
ProteomicsDBi248596 [Q8GXJ4-1]

Genome annotation databases

EnsemblPlantsiAT1G05200.1; AT1G05200.1; AT1G05200 [Q8GXJ4-1]
AT1G05200.2; AT1G05200.2; AT1G05200 [Q8GXJ4-1]
AT1G05200.5; AT1G05200.5; AT1G05200 [Q8GXJ4-2]
AT1G05200.6; AT1G05200.6; AT1G05200 [Q8GXJ4-1]
GeneIDi839268
GrameneiAT1G05200.1; AT1G05200.1; AT1G05200 [Q8GXJ4-1]
AT1G05200.2; AT1G05200.2; AT1G05200 [Q8GXJ4-1]
AT1G05200.5; AT1G05200.5; AT1G05200 [Q8GXJ4-2]
AT1G05200.6; AT1G05200.6; AT1G05200 [Q8GXJ4-1]
KEGGiath:AT1G05200

Organism-specific databases

AraportiAT1G05200
TAIRilocus:2207165, AT1G05200

Phylogenomic databases

eggNOGiKOG1052, Eukaryota
HOGENOMiCLU_007358_0_1_1
InParanoidiQ8GXJ4
OMAiEREQVFV
PhylomeDBiQ8GXJ4

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8GXJ4

Gene expression databases

ExpressionAtlasiQ8GXJ4, baseline and differential
GenevisibleiQ8GXJ4, AT

Family and domain databases

CDDicd19990, PBP1_GABAb_receptor_plant, 1 hit
InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR044440, GABAb_receptor_plant_PBP1
IPR001320, Iontro_rcpt
IPR017103, Iontropic_Glu_rcpt_pln
IPR028082, Peripla_BP_I
IPR001638, Solute-binding_3/MltF_N
PfamiView protein in Pfam
PF01094, ANF_receptor, 1 hit
PF00060, Lig_chan, 1 hit
PF00497, SBP_bac_3, 1 hit
PIRSFiPIRSF037090, Iontro_Glu-like_rcpt_pln, 1 hit
SMARTiView protein in SMART
SM00079, PBPe, 1 hit
SUPFAMiSSF53822, SSF53822, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLR34_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8GXJ4
Secondary accession number(s): O23048, Q8LGM9, Q9SWD9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: May 25, 2022
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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