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Entry version 130 (16 Oct 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Cleavage stimulation factor subunit 77

Gene

CSTF77

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

One of the multiple factors required for polyadenylation and 3'-end cleavage of pre-mRNAs (By similarity). Required for the targeted 3' processing of antisense transcripts that triggers transcriptional silencing of the corresponding sense gene (PubMed:19965720).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: TAIR

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, RNA-mediated gene silencing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cleavage stimulation factor subunit 771 Publication
Short name:
AtCstF-771 Publication
Short name:
AtCstF771 Publication
Alternative name(s):
CF-1 77 kDa subunitCurated
Cleavage stimulation factor 77 kDa subunitCurated
Short name:
CSTF 77 kDa subunitCurated
Protein SUPPRESSORS OF OVEREXPRESSED FCA 21 Publication
Short name:
SOF21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSTF771 Publication
Ordered Locus Names:At1g17760Imported
ORF Names:F11A6.10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G17760

The Arabidopsis Information Resource

More...
TAIRi
locus:2007973 AT1G17760

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impaired antisense-RNA-mediated gene silencing (e.g. suppression of overexpression of FCA-mediated FLC repression). Delayed flowering and female gametophytic lethality.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004313241 – 734Cleavage stimulation factor subunit 77Add BLAST734

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8GUP1

PRoteomics IDEntifications database

More...
PRIDEi
Q8GUP1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8GUP1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8GUP1 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Belongs to the CSTF complex (By similarity).

Forms a complex with cleavage and polyadenylation specificity factor (CPSF) subunits CPSF30, CSTF64, PCFS1, PCFS5 and FIPS5 (PubMed:12379796, PubMed:16282318, PubMed:18479511, PubMed:18221017, PubMed:20214900).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
23593, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q8GUP1, 5 interactors

Molecular INTeraction database

More...
MINTi
Q8GUP1

STRING: functional protein association networks

More...
STRINGi
3702.AT1G17760.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8GUP1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati20 – 52HAT 1Sequence analysisAdd BLAST33
Repeati54 – 85HAT 2Sequence analysisAdd BLAST32
Repeati93 – 128HAT 3Sequence analysisAdd BLAST36
Repeati139 – 172HAT 4Sequence analysisAdd BLAST34
Repeati198 – 237HAT 5Sequence analysisAdd BLAST40
Repeati246 – 278HAT 6Sequence analysisAdd BLAST33
Repeati280 – 312HAT 7Sequence analysisAdd BLAST33
Repeati314 – 345HAT 8Sequence analysisAdd BLAST32
Repeati347 – 379HAT 9Sequence analysisAdd BLAST33
Repeati382 – 414HAT 10Sequence analysisAdd BLAST33
Repeati416 – 450HAT 11Sequence analysisAdd BLAST35
Repeati474 – 505HAT 12Sequence analysisAdd BLAST32

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1914 Eukaryota
COG5107 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000030800

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8GUP1

KEGG Orthology (KO)

More...
KOi
K14408

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCYIDYL

Database of Orthologous Groups

More...
OrthoDBi
331411at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8GUP1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003107 HAT
IPR008847 Suf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05843 Suf, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00386 HAT, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8GUP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADKYIVEEA EALAKRALHS PIAQATPIYE QLLSLYPTSA RFWKQYVEAQ
60 70 80 90 100
MAVNNDDATK QIFSRCLLTC LQVPLWQCYI RFIRKVYDKK GAEGQEETTK
110 120 130 140 150
AFEFMLNYIG TDIASGPIWT EYIAFLKSLP ALNLNEDLHR KTALRKVYHR
160 170 180 190 200
AILTPTHHVE QLWKDYENFE NTVNRQLAKG LVNEYQPKFN SARAVYRERK
210 220 230 240 250
KYIEEIDWNM LAVPPTGTSK EETQWVAWKK FLSFEKGNPQ RIDTASSTKR
260 270 280 290 300
IIYAYEQCLM CLYHYPDVWY DYAEWHVKSG STDAAIKVFQ RALKAIPDSE
310 320 330 340 350
MLKYAFAEME ESRGAIQSAK KLYENILGAS TNSLAHIQYL RFLRRAEGVE
360 370 380 390 400
AARKYFLDAR KSPSCTYHVY IAFATMAFCI DKEPKVAHNI FEEGLKLYMS
410 420 430 440 450
EPVYILKYAD FLTRLNDDRN IRALFERALS TLPVEDSAEV WKRFIQFEQT
460 470 480 490 500
YGDLASILKV EQRMKEALSG KGEEGSSPPE SSLQDVVSRY SYMDLWPCTS
510 520 530 540 550
NDLDHLARQE LLVKNLNKKA GKTNLPHVPA AIGSVASSSK VVYPDTSQMV
560 570 580 590 600
VQDPTKKSEF ASSANPVAAS ASNTFPSTVT ATATHGSAST FDEIPKTTPP
610 620 630 640 650
ALVAFLANLP IVDGPTPNVD VVLSICLQSD FPTGQTVKQS FAAKGNPPSQ
660 670 680 690 700
NDPSGPTRGV SQRLPRDRRA TKRKDSDRQE EDDTATVQSQ PLPTDVFRLR
710 720 730
QMRKARGIAT SSQTPTGSTS YGSAFSGELS GSTG
Length:734
Mass (Da):82,650
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB12DEB0174E4463
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF99818 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti573N → S in AAM64166 (PubMed:12379796).1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF515697 mRNA Translation: AAM64166.1
AC034257 Genomic DNA Translation: AAF99818.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE29633.1
BT002320 mRNA Translation: AAN86153.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F86312

NCBI Reference Sequences

More...
RefSeqi
NP_173218.2, NM_101639.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G17760.1; AT1G17760.1; AT1G17760

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
838354

Gramene; a comparative resource for plants

More...
Gramenei
AT1G17760.1; AT1G17760.1; AT1G17760

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G17760

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF515697 mRNA Translation: AAM64166.1
AC034257 Genomic DNA Translation: AAF99818.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE29633.1
BT002320 mRNA Translation: AAN86153.1
PIRiF86312
RefSeqiNP_173218.2, NM_101639.3

3D structure databases

SMRiQ8GUP1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi23593, 9 interactors
IntActiQ8GUP1, 5 interactors
MINTiQ8GUP1
STRINGi3702.AT1G17760.1

Proteomic databases

PaxDbiQ8GUP1
PRIDEiQ8GUP1

Genome annotation databases

EnsemblPlantsiAT1G17760.1; AT1G17760.1; AT1G17760
GeneIDi838354
GrameneiAT1G17760.1; AT1G17760.1; AT1G17760
KEGGiath:AT1G17760

Organism-specific databases

AraportiAT1G17760
TAIRilocus:2007973 AT1G17760

Phylogenomic databases

eggNOGiKOG1914 Eukaryota
COG5107 LUCA
HOGENOMiHOG000030800
InParanoidiQ8GUP1
KOiK14408
OMAiLCYIDYL
OrthoDBi331411at2759
PhylomeDBiQ8GUP1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8GUP1

Gene expression databases

ExpressionAtlasiQ8GUP1 baseline and differential
GenevisibleiQ8GUP1 AT

Family and domain databases

InterProiView protein in InterPro
IPR003107 HAT
IPR008847 Suf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF05843 Suf, 1 hit
SMARTiView protein in SMART
SM00386 HAT, 10 hits
SUPFAMiSSF48452 SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTF77_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8GUP1
Secondary accession number(s): Q8LKG5, Q9FZ58
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 26, 2014
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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