UniProtKB - Q8GUH7 (CSCLC_ARATH)
Protein
CSC1-like protein HYP1
Gene
HYP1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Acts as an osmosensitive calcium-permeable cation channel.By similarity
GO - Molecular functioni
- calcium activated cation channel activity Source: GO_Central
- mechanosensitive ion channel activity Source: TAIR
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: CSC1-like protein HYP1Alternative name(s): HYPOTHETICAL PROTEIN 1 |
Gene namesi | Name:HYP1 Ordered Locus Names:At3g01100 ORF Names:T4P13.21 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G01100 |
TAIRi | locus:2102117, AT3G01100 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1 – 21 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 91 – 111 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 146 – 166 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 357 – 377 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 409 – 429 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 449 – 469 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 483 – 503 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 548 – 568 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 601 – 621 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 626 – 646 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000429810 | 1 – 703 | CSC1-like protein HYP1Add BLAST | 703 |
Proteomic databases
PaxDbi | Q8GUH7 |
ProteomicsDBi | 220352 [Q8GUH7-1] |
PTM databases
iPTMneti | Q8GUH7 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q8GUH7, baseline and differential |
Genevisiblei | Q8GUH7, AT |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 228 – 300 | Sequence analysisAdd BLAST | 73 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1134, Eukaryota |
HOGENOMi | CLU_002458_7_1_1 |
InParanoidi | Q8GUH7 |
PhylomeDBi | Q8GUH7 |
Family and domain databases
InterProi | View protein in InterPro IPR032880, Csc1_N IPR027815, PHM7_cyt IPR003864, RSN1_7TM |
Pfami | View protein in Pfam PF14703, PHM7_cyt, 1 hit PF02714, RSN1_7TM, 1 hit PF13967, RSN1_TM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketNote: A number of isoforms are produced. According to EST sequences.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8GUH7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLSALLTSV GINLGLCFLF FTLYSILRKQ PSNVTVYGPR LVKKDGKSQQ
60 70 80 90 100
SNEFNLERLL PTAGWVKRAL EPTNDEILSN LGLDALVFIR VFVFSIRVFS
110 120 130 140 150
FASVVGIFIL LPVNYMGTEF EEFFDLPKKS MDNFSISNVN DGSNKLWIHF
160 170 180 190 200
CAIYIFTAVV CSLLYYEHKY ILTKRIAHLY SSKPQPQEFT VLVSGVPLVS
210 220 230 240 250
GNSISETVEN FFREYHSSSY LSHIVVHRTD KLKVLMNDAE KLYKKLTRVK
260 270 280 290 300
SGSISRQKSR WGGFLGMFGN NVDVVDHYQK KLDKLEDDMR LKQSLLAGEE
310 320 330 340 350
VPAAFVSFRT RHGAAIATNI QQGIDPTQWL TEAAPEPEDV HWPFFTASFV
360 370 380 390 400
RRWISNVVVL VAFVALLILY IVPVVLVQGL ANLHQLETWF PFLKGILNMK
410 420 430 440 450
IVSQVITGYL PSLIFQLFLL IVPPIMLLLS SMQGFISHSQ IEKSACIKLL
460 470 480 490 500
IFTVWNSFFA NVLSGSALYR VNVFLEPKTI PRVLAAAVPA QASFFVSYVV
510 520 530 540 550
TSGWTGLSSE ILRLVPLLWS FITKLFGKED DKEFEVPSTP FCQEIPRILF
560 570 580 590 600
FGLLGITYFF LSPLILPFLL VYYCLGYIIY RNQLLNVYAA KYETGGKFWP
610 620 630 640 650
IVHSYTIFSL VLMHIIAVGL FGLKELPVAS SLTIPLPVLT VLFSIYCQRR
660 670 680 690 700
FLPNFKSYPT QCLVNKDKAD EREQNMSEFY SELVVAYRDP ALSASQDSRD
ISP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1I9LRK0 | A0A1I9LRK0_ARATH | Uncharacterized protein | HYP1 ATHYP1, hypothetical protein 1, At3g01100, At3g01110, T4P13.21 | 749 | Annotation score: | ||
A0A1I9LRJ9 | A0A1I9LRJ9_ARATH | Uncharacterized protein | HYP1 ATHYP1, hypothetical protein 1, At3g01100, At3g01110, T4P13.21 | 588 | Annotation score: | ||
F4J116 | F4J116_ARATH | Uncharacterized protein | HYP1 ATHYP1, hypothetical protein 1, At3g01100, At3g01110, T4P13.21 | 596 | Annotation score: |
Sequence cautioni
The sequence AAF26164 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA55187 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA56145 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 273 | D → G in BAD94293 (Ref. 5) Curated | 1 | |
Sequence conflicti | 584 | L → V in CAA56145 (PubMed:7816049).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78422 mRNA Translation: CAA55187.1 Different initiation. X79707 Genomic DNA Translation: CAA56145.1 Sequence problems. AC008261 Genomic DNA Translation: AAF26164.1 Sequence problems. CP002686 Genomic DNA Translation: AEE73610.1 BT002498 mRNA Translation: AAO00858.1 BT008419 mRNA Translation: AAP37778.1 AK221381 mRNA Translation: BAD94293.1 |
PIRi | S51583 |
RefSeqi | NP_186759.2, NM_110975.5 [Q8GUH7-1] |
Genome annotation databases
EnsemblPlantsi | AT3G01100.1; AT3G01100.1; AT3G01100 [Q8GUH7-1] |
GeneIDi | 821205 |
Gramenei | AT3G01100.1; AT3G01100.1; AT3G01100 [Q8GUH7-1] |
KEGGi | ath:AT3G01100 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78422 mRNA Translation: CAA55187.1 Different initiation. X79707 Genomic DNA Translation: CAA56145.1 Sequence problems. AC008261 Genomic DNA Translation: AAF26164.1 Sequence problems. CP002686 Genomic DNA Translation: AEE73610.1 BT002498 mRNA Translation: AAO00858.1 BT008419 mRNA Translation: AAP37778.1 AK221381 mRNA Translation: BAD94293.1 |
PIRi | S51583 |
RefSeqi | NP_186759.2, NM_110975.5 [Q8GUH7-1] |
3D structure databases
SMRi | Q8GUH7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT3G01100.1 |
PTM databases
iPTMneti | Q8GUH7 |
Proteomic databases
PaxDbi | Q8GUH7 |
ProteomicsDBi | 220352 [Q8GUH7-1] |
Genome annotation databases
EnsemblPlantsi | AT3G01100.1; AT3G01100.1; AT3G01100 [Q8GUH7-1] |
GeneIDi | 821205 |
Gramenei | AT3G01100.1; AT3G01100.1; AT3G01100 [Q8GUH7-1] |
KEGGi | ath:AT3G01100 |
Organism-specific databases
Araporti | AT3G01100 |
TAIRi | locus:2102117, AT3G01100 |
Phylogenomic databases
eggNOGi | KOG1134, Eukaryota |
HOGENOMi | CLU_002458_7_1_1 |
InParanoidi | Q8GUH7 |
PhylomeDBi | Q8GUH7 |
Miscellaneous databases
PROi | PR:Q8GUH7 |
Gene expression databases
ExpressionAtlasi | Q8GUH7, baseline and differential |
Genevisiblei | Q8GUH7, AT |
Family and domain databases
InterProi | View protein in InterPro IPR032880, Csc1_N IPR027815, PHM7_cyt IPR003864, RSN1_7TM |
Pfami | View protein in Pfam PF14703, PHM7_cyt, 1 hit PF02714, RSN1_7TM, 1 hit PF13967, RSN1_TM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSCLC_ARATH | |
Accessioni | Q8GUH7Primary (citable) accession number: Q8GUH7 Secondary accession number(s): Q39075, Q39126, Q56YE2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 9, 2014 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families