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UniProtKB - Q8GUE4 (GERS_CINTE)
Protein
Geraniol synthase, chloroplastic
Gene
GerS
Organism
Cinnamomum tenuipile (Alseodaphne mollis)
Status
Functioni
Monoterpene synthase that catalyzes the formation of geraniol from geranyl diphosphate.
1 PublicationMiscellaneous
Exclusively observed in the geraniol chemotype of this organism.
Catalytic activityi
- EC:3.1.7.111 Publication
Cofactori
Kineticsi
- KM=55.8 µM for geranyl diphosphate1 Publication
pH dependencei
Optimum pH is 7.1 Publication
: terpenoid biosynthesis Pathwayi
This protein is involved in the pathway terpenoid biosynthesis, which is part of Secondary metabolite biosynthesis.View all proteins of this organism that are known to be involved in the pathway terpenoid biosynthesis and in Secondary metabolite biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 338 | Magnesium 1By similarity | 1 | |
Metal bindingi | 338 | Magnesium 2By similarity | 1 | |
Metal bindingi | 342 | Magnesium 1By similarity | 1 | |
Metal bindingi | 342 | Magnesium 2By similarity | 1 | |
Metal bindingi | 482 | Magnesium 3By similarity | 1 | |
Metal bindingi | 486 | Magnesium 3By similarity | 1 | |
Metal bindingi | 490 | Magnesium 3By similarity | 1 |
GO - Molecular functioni
- hydrolase activity Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- manganese ion binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- terpene synthase activity Source: InterPro
GO - Biological processi
- diterpenoid biosynthetic process Source: InterPro
- geranyl diphosphate metabolic process Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Ligand | Magnesium, Manganese, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.7.11, 12920 |
UniPathwayi | UPA00213 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GerS |
Organismi | Cinnamomum tenuipile (Alseodaphne mollis) |
Taxonomic identifieri | 192326 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Magnoliidae › Laurales › Lauraceae › Cinnamomum |
Subcellular locationi
Chloroplast
- chloroplast Curated
Chloroplast
- chloroplast Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chloroplast, PlastidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 50 | ChloroplastSequence analysisAdd BLAST | 50 | |
ChainiPRO_0000418927 | 51 – 603 | Geraniol synthase, chloroplasticAdd BLAST | 553 |
Expressioni
Tissue specificityi
Expressed in the oil cells of the leaves.1 Publication
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 338 – 342 | DDXXD motif | 5 |
Domaini
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.
Sequence similaritiesi
Keywords - Domaini
Transit peptideFamily and domain databases
CDDi | cd00684, Terpene_cyclase_plant_C1, 1 hit |
Gene3Di | 1.10.600.10, 1 hit 1.50.10.130, 1 hit |
InterProi | View protein in InterPro IPR008949, Isoprenoid_synthase_dom_sf IPR034741, Terpene_cyclase-like_1_C IPR044814, Terpene_cyclase_plant_C1 IPR001906, Terpene_synth_N IPR036965, Terpene_synth_N_sf IPR005630, Terpene_synthase_metal-bd IPR008930, Terpenoid_cyclase/PrenylTrfase |
Pfami | View protein in Pfam PF01397, Terpene_synth, 1 hit PF03936, Terpene_synth_C, 1 hit |
SFLDi | SFLDG01019, Terpene_Cyclase_Like_1_C_Termi, 1 hit |
SUPFAMi | SSF48239, SSF48239, 1 hit SSF48576, SSF48576, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8GUE4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALQMIAPFL SSFLPNPRHS LAAHGLTHQK CVSKHISCST TTPTYSTTVP
60 70 80 90 100
RRSGNYKPSI WDYDFVQSLG SGYKVEAHGT RVKKLKEVVK HLLKETDSSL
110 120 130 140 150
AQIELIDKLR RLGLRWLFKN EIKQVLYTIS SDNTSIEMRK DLHAVSTRFR
160 170 180 190 200
LLRQHGYKVS TDVFNDFKDE KGCFKPSLSM DIKGMLSLYE ASHLAFQGET
210 220 230 240 250
VLDEARAFVS THLMDIKENI DPILHKKVEH ALDMPLHWRL EKLEARWYMD
260 270 280 290 300
IYMREEGMNS SLLELAMLHF NIVQTTFQTN LKSLSRWWKD LGLGEQLSFT
310 320 330 340 350
RDRLVECFFW AAAMTPEPQF GRCQEVVAKV AQLIIIIDDI YDVYGTVDEL
360 370 380 390 400
ELFTNAIDRW DLEAMEQLPE YMKTCFLALY NSINEIGYDI LKEEGRNVIP
410 420 430 440 450
YLRNTWTELC KAFLVEAKWY SSGYTPTLEE YLQTSWISIG SLPMQTYVFA
460 470 480 490 500
LLGKNLAPES SDFAEKISDI LRLGGMMIRL PDDLGTSTDE LKRGDVPKSI
510 520 530 540 550
QCYMHEAGVT EDVARDHIMG LFQETWKKLN EYLVESSLPH AFIDHAMNLG
560 570 580 590 600
RVSYCTYKHG DGFSDGFGDP GSQEKKMFMS LFAEPLQVDE AKGISFYVDG
GSA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ457070 mRNA Translation: CAD29734.2 |
Genome annotation databases
KEGGi | ag:CAD29734 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ457070 mRNA Translation: CAD29734.2 |
3D structure databases
AlphaFoldDBi | Q8GUE4 |
SMRi | Q8GUE4 |
ModBasei | Search... |
Genome annotation databases
KEGGi | ag:CAD29734 |
Enzyme and pathway databases
UniPathwayi | UPA00213 |
BRENDAi | 3.1.7.11, 12920 |
Family and domain databases
CDDi | cd00684, Terpene_cyclase_plant_C1, 1 hit |
Gene3Di | 1.10.600.10, 1 hit 1.50.10.130, 1 hit |
InterProi | View protein in InterPro IPR008949, Isoprenoid_synthase_dom_sf IPR034741, Terpene_cyclase-like_1_C IPR044814, Terpene_cyclase_plant_C1 IPR001906, Terpene_synth_N IPR036965, Terpene_synth_N_sf IPR005630, Terpene_synthase_metal-bd IPR008930, Terpenoid_cyclase/PrenylTrfase |
Pfami | View protein in Pfam PF01397, Terpene_synth, 1 hit PF03936, Terpene_synth_C, 1 hit |
SFLDi | SFLDG01019, Terpene_Cyclase_Like_1_C_Termi, 1 hit |
SUPFAMi | SSF48239, SSF48239, 1 hit SSF48576, SSF48576, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GERS_CINTE | |
Accessioni | Q8GUE4Primary (citable) accession number: Q8GUE4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2012 |
Last sequence update: | March 1, 2004 | |
Last modified: | May 25, 2022 | |
This is version 71 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families