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UniProtKB - Q8GMH4 (SGCD_STRGL)
Protein
2-amino-4-deoxychorismate synthase
Gene
sgcD
Organism
Streptomyces globisporus
Status
Functioni
Converts chorismate to 2-amino-4-deoxychorismate (ADIC). Involved in the biosynthesis of the benzoxazolinate moiety of the enediyne antitumor antibiotic C-1027.
1 PublicationCatalytic activityi
- EC:2.6.1.861 Publication
Cofactori
Mg2+1 Publication
GO - Molecular functioni
- transaminase activity Source: UniProtKB
GO - Biological processi
- antibiotic biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Transferase |
Biological process | Antibiotic biosynthesis |
Ligand | Magnesium |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:sgcD |
Organismi | Streptomyces globisporus |
Taxonomic identifieri | 1908 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000418509 | 1 – 493 | 2-amino-4-deoxychorismate synthaseAdd BLAST | 493 |
Family & Domainsi
Sequence similaritiesi
Belongs to the anthranilate synthase component I family.Curated
Family and domain databases
Gene3Di | 3.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR005801, ADC_synthase IPR019999, Anth_synth_I-like IPR006805, Anth_synth_I_N IPR015890, Chorismate_C |
PANTHERi | PTHR11236, PTHR11236, 1 hit |
Pfami | View protein in Pfam PF04715, Anth_synt_I_N, 1 hit PF00425, Chorismate_bind, 1 hit |
PRINTSi | PR00095, ANTSNTHASEI |
SUPFAMi | SSF56322, SSF56322, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8GMH4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDQCVVSAP VRVRTRRLDV KETGALPAYR ALAEHFGPDE VYLLESAAGP
60 70 80 90 100
ARDRRHQFVG FGALLSLSVT DRVVRVEGVP ALRGLLLERA GALLEDGPQG
110 120 130 140 150
LRLRTAGGLW PLLRAMRDMF DAEGSASGFR FGFLGFFGYD TARYIEDLPH
160 170 180 190 200
LIENRPGLPD VRMVLHRGSV VTDLATGRCE LLLHESPYWP GLAPETVTGL
210 220 230 240 250
LADVEQAWPD PSADGFPASA VTDDSAPEVF ANDVERCLKH IAVGDIYQVQ
260 270 280 290 300
IGHELSIRST ADPADVYQRL RGRNASPYMY LAGIDGHRLI GASPELFVRI
310 320 330 340 350
EDGEVTMRPI AGTVPRSGAD GGIAAGVRLR SDPKEIAEHT MLVDLCRNDI
360 370 380 390 400
GRIARPNTLD VPDQLDVEGY SHVLHLVSTV VGRARVDTDA FDTIAALFPA
410 420 430 440 450
GTMTGAPKIR AMEIIESVER SRRGLYAGAL GLLDVGGYTN LALCIRTLFH
460 470 480 490
HEGVYRTRAS AGIVADSEPG AEWTETLAKM SATHWAVTGE ELL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY048670 Genomic DNA Translation: AAL06664.1 |
Genome annotation databases
KEGGi | ag:AAL06664 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY048670 Genomic DNA Translation: AAL06664.1 |
3D structure databases
SMRi | Q8GMH4 |
ModBasei | Search... |
Genome annotation databases
KEGGi | ag:AAL06664 |
Family and domain databases
Gene3Di | 3.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR005801, ADC_synthase IPR019999, Anth_synth_I-like IPR006805, Anth_synth_I_N IPR015890, Chorismate_C |
PANTHERi | PTHR11236, PTHR11236, 1 hit |
Pfami | View protein in Pfam PF04715, Anth_synt_I_N, 1 hit PF00425, Chorismate_bind, 1 hit |
PRINTSi | PR00095, ANTSNTHASEI |
SUPFAMi | SSF56322, SSF56322, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SGCD_STRGL | |
Accessioni | Q8GMH4Primary (citable) accession number: Q8GMH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2012 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 55 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |