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Protein
Submitted name:

NalP

Gene

nalP

Organism
Neisseria meningitidis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

MEROPS protease database

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MEROPSi
S08.160

Transport Classification Database

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TCDBi
1.B.12.9.1 the autotransporter-1 (at-1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NalPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nalPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeisseria meningitidisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri487 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500430616530 – 1083Sequence analysisAdd BLAST1054

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UYNX-ray2.60X776-1083[»]
1UYOX-ray3.20X776-1083[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8GKS5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8GKS5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8GKS5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini809 – 1083AutotransporterInterPro annotationAdd BLAST275

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107ZYM Bacteria
COG1404 LUCA

Family and domain databases

Conserved Domains Database

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CDDi
cd04848 Peptidases_S8_Autotransporter_, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.128.130, 1 hit
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005546 Autotransporte_beta
IPR036709 Autotransporte_beta_dom_sf
IPR013425 Autotrns_rpt
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR034061 Peptidases_S8_Autotransporter

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03797 Autotransporter, 1 hit
PF00082 Peptidase_S8, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00723 SUBTILISIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00869 Autotransporter, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF103515 SSF103515, 1 hit
SSF52743 SSF52743, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02601 autotrns_rpt, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51208 AUTOTRANSPORTER, 1 hit
PS00138 SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8GKS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTTPTFPTK TFKPTAMALA VATTLSACLG GGGGGTSAPD FNAGGTGIGS
60 70 80 90 100
NSRATTAKSA AVSYAGIKNE MCKDRSMLCA GRDDVAVTDR DAKINAPPPP
110 120 130 140 150
NLHTGDFPNP NDAYKNLINL KPAIEAGYTG RGVEVGIVDT GESVGSISFP
160 170 180 190 200
ELYGRKEHGY NENYKNYTAY MRKEAPEDGG GKDIEASFDD EAVIETEAKP
210 220 230 240 250
TDIRHVKEIG HIDLVSHIIG GRSVDGRPAG GIAPDATLHI MNTNDGTKNE
260 270 280 290 300
MMVAAIRNAW VKLGERGVRI VNNSFGTTSR AGTADLFQIA NSEEQYRQAL
310 320 330 340 350
LDYSGGDKTD EGIRLMQQSD YGNLSYHIRN KNMLFIFSTG NDAQAQPNTY
360 370 380 390 400
ALLPFYEKDA QKGIITVAGV DRSGEKFKRE MYGEPGTEPL EYGSNHCGIT
410 420 430 440 450
AMWCLSAPYE ASVRFTRTNP IQIAGTSFSA PIVTGTAALL LQKYPWMSND
460 470 480 490 500
NLRTTLLTTA QDIGAVGVDS KFGWGLLDAG KAMNGPASFP FGDFTADTKG
510 520 530 540 550
TSDIAYSFRN DISGTGGLIK KGGSQLQLHG NNTYTGKTII EGGSLVLYGN
560 570 580 590 600
NKSDMRVETK GALIYNGAAS GGSLNSDGIV YLADTDQSGA NETVHIKGSL
610 620 630 640 650
QLDGKGTLYT RLGKLLKVDG TAIIGGKLYM SARGKGAGYL NSTGRRVPFL
660 670 680 690 700
SAAKIGQDYS FFTNIETDGG LLASLDSVEK TAGSEGDTLS YYVRRGNAAR
710 720 730 740 750
TASAAAHSAP AGLKHAVEQG GSNLENLMVE LDASESSATP ETVETAAADR
760 770 780 790 800
TDMPGIRPYG ATFRAAAAVQ HANAADGVRI FNSLAATVYA DSTAAHADMQ
810 820 830 840 850
GRRLKAVSDG LDHNGTGLRV IAQTQQDGGT WEQGGVEGKM RGSTQTVGIA
860 870 880 890 900
AKTGENTTAA ATLGMGRSTW SENSANAKTD SISLFAGIRH DAGDIGYLKG
910 920 930 940 950
LFSYGRYKNS ISRSTGADEH AEGSVNGTLM QLGALGGVNV PFAATGDLTV
960 970 980 990 1000
EGGLRYDLLK QDAFAEKGSA LGWSGNSLTE GTLVGLAGLK LSQPLSDKAV
1010 1020 1030 1040 1050
LFATAGVERD LNGRDYTVTG GFTGATAATG KTGARNMPHT RLVAGLGADV
1060 1070 1080
EFGNGWNGLA RYSYAGSKQY GNHSGRVGVG YRF
Length:1,083
Mass (Da):113,640
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF34CE1D0EDB13C0E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY150284 Genomic DNA Translation: AAN71715.1

NCBI Reference Sequences

More...
RefSeqi
WP_002248900.1, NZ_QQJI01000128.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150284 Genomic DNA Translation: AAN71715.1
RefSeqiWP_002248900.1, NZ_QQJI01000128.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UYNX-ray2.60X776-1083[»]
1UYOX-ray3.20X776-1083[»]
ProteinModelPortaliQ8GKS5
SMRiQ8GKS5
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS08.160
TCDBi1.B.12.9.1 the autotransporter-1 (at-1) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4107ZYM Bacteria
COG1404 LUCA

Miscellaneous databases

EvolutionaryTraceiQ8GKS5

Family and domain databases

CDDicd04848 Peptidases_S8_Autotransporter_, 1 hit
Gene3Di2.40.128.130, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR005546 Autotransporte_beta
IPR036709 Autotransporte_beta_dom_sf
IPR013425 Autotrns_rpt
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR034061 Peptidases_S8_Autotransporter
PfamiView protein in Pfam
PF03797 Autotransporter, 1 hit
PF00082 Peptidase_S8, 1 hit
PRINTSiPR00723 SUBTILISIN
SMARTiView protein in SMART
SM00869 Autotransporter, 1 hit
SUPFAMiSSF103515 SSF103515, 1 hit
SSF52743 SSF52743, 1 hit
TIGRFAMsiTIGR02601 autotrns_rpt, 1 hit
PROSITEiView protein in PROSITE
PS51208 AUTOTRANSPORTER, 1 hit
PS00138 SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8GKS5_NEIME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8GKS5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: January 16, 2019
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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