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Protein

dTDP-glucose 4,6-dehydratase

Gene

rmlB

Organism
Streptococcus suis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

NAD+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei101NADCombined sources1
Binding sitei161NADCombined sources1
Binding sitei165NADCombined sources1
Binding sitei191NAD; via amide nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi14 – 16NADCombined sources3
Nucleotide bindingi37 – 40NADCombined sources4
Nucleotide bindingi62 – 63NADCombined sources2
Nucleotide bindingi82 – 86NADCombined sources5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseUniRule annotationImported
LigandNADCombined sources, Nucleotide-bindingCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
dTDP-glucose 4,6-dehydrataseUniRule annotation (EC:4.2.1.46UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rmlBImported
Synonyms:rfbBImported
ORF Names:A6M16_03315Imported, APQ97_03200Imported, CWI26_07360Imported, CWM22_07885Imported, ERS132370_01395Imported, ERS132374_01253Imported, ERS132410_01682Imported, ERS132414_00580Imported, ERS132421_00412Imported, ERS132431_00441Imported, ERS132440_01438Imported, ERS132444_01827Imported, ERS132457_01850Imported, ERS132458_00971Imported, ERS132461_00211Imported, ERS132462_01604Imported, ERS132502_01610Imported, ERS132531_00495Imported, ERS132536_02274Imported, LI88_04195Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus suisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1307 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000231863 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000074903 Componenti: Unassembled WGS sequence
  • UP000072933 Componenti: Unassembled WGS sequence
  • UP000072794 Componenti: Unassembled WGS sequence
  • UP000075182 Componenti: Unassembled WGS sequence
  • UP000072147 Componenti: Unassembled WGS sequence
  • UP000073200 Componenti: Unassembled WGS sequence
  • UP000077401 Componenti: Chromosome
  • UP000074825 Componenti: Unassembled WGS sequence
  • UP000071533 Componenti: Unassembled WGS sequence
  • UP000072226 Componenti: Unassembled WGS sequence
  • UP000070276 Componenti: Chromosome
  • UP000236491 Componenti: Unassembled WGS sequence
  • UP000072711 Componenti: Unassembled WGS sequence
  • UP000069831 Componenti: Unassembled WGS sequence
  • UP000073485 Componenti: Unassembled WGS sequence
  • UP000232580 Componenti: Chromosome
  • UP000074356 Componenti: Unassembled WGS sequence
  • UP000072003 Componenti: Unassembled WGS sequence
  • UP000073388 Componenti: Unassembled WGS sequence

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8GIP9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 318NAD(P)-bd_domInterPro annotationAdd BLAST311

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C1B Bacteria
COG1088 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005888 dTDP_Gluc_deHydtase
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16363 GDP_Man_Dehyd, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01181 dTDP_gluc_dehyt, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8GIP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQFKNIIVT GGAGFIGSNF VHYVYNNHPD VHVTVLDKLT YAGNKANLEA
60 70 80 90 100
ILGDRVELVV GDIADAELVD KLAAKADAIV HYAAESHNDN SLNDPSPFIH
110 120 130 140 150
TNFIGTYTLL EAARKYDIRF HHVSTDEVYG DLPLREDLPG HGEGPGEKFT
160 170 180 190 200
AETNYNPSSP YSSTKAASDL IVKAWVRSFG VKATISNCSN NYGPYQHIEK
210 220 230 240 250
FIPRQITNIL AGIKPKLYGE GKNVRDWIHT NDHSTGVWAI LTKGRMGETY
260 270 280 290 300
LIGADGEKNN KEVLELILEK MGQPKDAYDH VTDRAGHDLR YAIDASKLRD
310 320 330 340
ELGWTPQFTD FSQGLEETIQ WYTDNQDWWK AEKEAVEANY AKTQEVIK
Length:348
Mass (Da):38,932
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEEA3464D7CBCF2A1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP012911 Genomic DNA Translation: AML46114.1
CP015557 Genomic DNA Translation: ANC99563.1
CP025043 Genomic DNA Translation: AUA19301.1
CP025095 Genomic DNA Translation: AUC91816.1
AJ509828 Genomic DNA Translation: CAD49092.1
FIFN01000018 Genomic DNA Translation: CYU24363.1
FIFP01000015 Genomic DNA Translation: CYU37597.1
FIHA01000008 Genomic DNA Translation: CYU70721.1
FIHG01000001 Genomic DNA Translation: CYU72753.1
FIGO01000010 Genomic DNA Translation: CYV01660.1
FIHS01000004 Genomic DNA Translation: CYV28548.1
FIIX01000003 Genomic DNA Translation: CYV61795.1
FIIB01000011 Genomic DNA Translation: CYV67502.1
FIIS01000008 Genomic DNA Translation: CYV81693.1
FIIF01000015 Genomic DNA Translation: CYV94350.1
FIID01000015 Genomic DNA Translation: CYV94732.1
FIIR01000027 Genomic DNA Translation: CYW07796.1
FIKN01000012 Genomic DNA Translation: CYW95377.1
FILX01000005 Genomic DNA Translation: CYX42215.1
FIMD01000036 Genomic DNA Translation: CYY02939.1
JRHU01000008 Genomic DNA Translation: PNS45390.1

NCBI Reference Sequences

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RefSeqi
WP_002937117.1, NZ_PYUF01000003.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AML46114; AML46114; APQ97_03200
ANC99563; ANC99563; A6M16_03315
CYU24363; CYU24363; ERS132462_01604
CYU37597; CYU37597; ERS132374_01253
CYU70721; CYU70721; ERS132414_00580
CYU72753; CYU72753; ERS132421_00412
CYV01660; CYV01660; ERS132410_01682
CYV28548; CYV28548; ERS132431_00441
CYV61795; CYV61795; ERS132461_00211
CYV67502; CYV67502; ERS132440_01438
CYV81693; CYV81693; ERS132458_00971
CYV94350; CYV94350; ERS132444_01827
CYV94732; CYV94732; ERS132370_01395
CYW07796; CYW07796; ERS132457_01850
CYW95377; CYW95377; ERS132502_01610
CYX42215; CYX42215; ERS132531_00495
CYY02939; CYY02939; ERS132536_02274

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1307.1317.peg.1749

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP012911 Genomic DNA Translation: AML46114.1
CP015557 Genomic DNA Translation: ANC99563.1
CP025043 Genomic DNA Translation: AUA19301.1
CP025095 Genomic DNA Translation: AUC91816.1
AJ509828 Genomic DNA Translation: CAD49092.1
FIFN01000018 Genomic DNA Translation: CYU24363.1
FIFP01000015 Genomic DNA Translation: CYU37597.1
FIHA01000008 Genomic DNA Translation: CYU70721.1
FIHG01000001 Genomic DNA Translation: CYU72753.1
FIGO01000010 Genomic DNA Translation: CYV01660.1
FIHS01000004 Genomic DNA Translation: CYV28548.1
FIIX01000003 Genomic DNA Translation: CYV61795.1
FIIB01000011 Genomic DNA Translation: CYV67502.1
FIIS01000008 Genomic DNA Translation: CYV81693.1
FIIF01000015 Genomic DNA Translation: CYV94350.1
FIID01000015 Genomic DNA Translation: CYV94732.1
FIIR01000027 Genomic DNA Translation: CYW07796.1
FIKN01000012 Genomic DNA Translation: CYW95377.1
FILX01000005 Genomic DNA Translation: CYX42215.1
FIMD01000036 Genomic DNA Translation: CYY02939.1
JRHU01000008 Genomic DNA Translation: PNS45390.1
RefSeqiWP_002937117.1, NZ_PYUF01000003.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KEPX-ray1.80A/B1-348[»]
1KERX-ray2.20A/B1-348[»]
1OC2X-ray1.50A/B1-348[»]

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAML46114; AML46114; APQ97_03200
ANC99563; ANC99563; A6M16_03315
CYU24363; CYU24363; ERS132462_01604
CYU37597; CYU37597; ERS132374_01253
CYU70721; CYU70721; ERS132414_00580
CYU72753; CYU72753; ERS132421_00412
CYV01660; CYV01660; ERS132410_01682
CYV28548; CYV28548; ERS132431_00441
CYV61795; CYV61795; ERS132461_00211
CYV67502; CYV67502; ERS132440_01438
CYV81693; CYV81693; ERS132458_00971
CYV94350; CYV94350; ERS132444_01827
CYV94732; CYV94732; ERS132370_01395
CYW07796; CYW07796; ERS132457_01850
CYW95377; CYW95377; ERS132502_01610
CYX42215; CYX42215; ERS132531_00495
CYY02939; CYY02939; ERS132536_02274
PATRICifig|1307.1317.peg.1749

Phylogenomic databases

eggNOGiENOG4105C1B Bacteria
COG1088 LUCA

Miscellaneous databases

EvolutionaryTraceiQ8GIP9

Family and domain databases

InterProiView protein in InterPro
IPR005888 dTDP_Gluc_deHydtase
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF16363 GDP_Man_Dehyd, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01181 dTDP_gluc_dehyt, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8GIP9_STRSU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8GIP9
Secondary accession number(s): F4EEB1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: December 5, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported
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