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Protein

Malate dehydrogenase

Gene

mdh

Organism
Francisella tularensis subsp. tularensis
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotationImported
OrganismiFrancisella tularensis subsp. tularensisImported
Taxonomic identifieri119856 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Structurei

3D structure databases

SMRiQ8G942
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 143Ldh_1_NInterPro annotationAdd BLAST139
Domaini147 – 312Ldh_1_CInterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q8G942-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARKKITLVG AGNIGGTLAH LALIKQLGDV VLFDIAQGMP NGKALDLLQT
60 70 80 90 100
CPIEGVDFKV RGTNDYKDLE NSDVVIVTAG VPRKPGMSRD DLLGINIKVM
110 120 130 140 150
QTVGEGIKHN CPNAFVICIT NPLDIMVNML QKFSGVPDNK IVGMAGVLDS
160 170 180 190 200
ARFRTFLADE LNVSVQQVQA YVMGGHGDTM VPLTKMSNVA GVSLEQLVKE
210 220 230 240 250
GKLKQERLDA IVSRTRSGGG EIVALLKTGS AYYAPAAAGI QMAESFLKDK
260 270 280 290 300
KMILPCAAKV KAGMYGLDED LFVGVPTEIS ANGVRPIEVE ISDKEREQLQ
310
VSINAIKDLN KAAAEILAK
Length:319
Mass (Da):34,091
Last modified:March 1, 2003 - v1
Checksum:i13749C47CF1F704D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513300 Genomic DNA Translation: AAN37788.1
AF513301 Genomic DNA Translation: AAN37789.1
AF513302 Genomic DNA Translation: AAN37790.1
AF513303 Genomic DNA Translation: AAN37791.1
AF513304 Genomic DNA Translation: AAN37792.1
AF513305 Genomic DNA Translation: AAN37793.1
AF513306 Genomic DNA Translation: AAN37794.1
AF513307 Genomic DNA Translation: AAN37795.1
AF513308 Genomic DNA Translation: AAN37796.1
AF513309 Genomic DNA Translation: AAN37797.1
AF513310 Genomic DNA Translation: AAN37798.1
AF513311 Genomic DNA Translation: AAN37799.1
AF513312 Genomic DNA Translation: AAN37800.1
AF513313 Genomic DNA Translation: AAN37801.1
AF513314 Genomic DNA Translation: AAN37802.1
RefSeqiWP_003026154.1, NZ_CP017155.1

Genome annotation databases

PATRICifig|264.20.peg.1988

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513300 Genomic DNA Translation: AAN37788.1
AF513301 Genomic DNA Translation: AAN37789.1
AF513302 Genomic DNA Translation: AAN37790.1
AF513303 Genomic DNA Translation: AAN37791.1
AF513304 Genomic DNA Translation: AAN37792.1
AF513305 Genomic DNA Translation: AAN37793.1
AF513306 Genomic DNA Translation: AAN37794.1
AF513307 Genomic DNA Translation: AAN37795.1
AF513308 Genomic DNA Translation: AAN37796.1
AF513309 Genomic DNA Translation: AAN37797.1
AF513310 Genomic DNA Translation: AAN37798.1
AF513311 Genomic DNA Translation: AAN37799.1
AF513312 Genomic DNA Translation: AAN37800.1
AF513313 Genomic DNA Translation: AAN37801.1
AF513314 Genomic DNA Translation: AAN37802.1
RefSeqiWP_003026154.1, NZ_CP017155.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P7MX-ray2.20A/B/C/D1-319[»]
SMRiQ8G942
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi3191869
Structural Biology KnowledgebaseSearch...

Genome annotation databases

PATRICifig|264.20.peg.1988

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8G942_FRATL
AccessioniPrimary (citable) accession number: Q8G942
Secondary accession number(s): A0A0K1NS88
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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