UniProtKB - Q8G847 (FRUK_BIFLO)
Protein
Fructose import ATP-binding protein FruK
Gene
fruK
Organism
Bifidobacterium longum (strain NCC 2705)
Status
Functioni
Part of the high-affinity ABC transporter complex FruEKFG involved in fructose uptake. Can also transport ribose and xylose, with lower affinity. Probably responsible for energy coupling to the transport system.1 Publication
Catalytic activityi
- This reaction proceeds in the forward1 Publication direction.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 40 – 47 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
Keywordsi
Molecular function | Translocase |
Biological process | Sugar transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BLON206672:G1FZZ-34-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.2.23, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:fruK1 Publication Ordered Locus Names:BL0034Imported |
Organismi | Bifidobacterium longum (strain NCC 2705) |
Taxonomic identifieri | 206672 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium › |
Proteomesi |
|
Subcellular locationi
- Cell membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated
GO - Cellular componenti
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000439269 | 1 – 513 | Fructose import ATP-binding protein FruKAdd BLAST | 513 |
Interactioni
Subunit structurei
The complex is composed of an ATP-binding protein (FruK), two transmembrane proteins (FruF and FruG) and a solute-binding protein (FruE).
1 PublicationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 244 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 237 | |
Domaini | 262 – 505 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 244 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily.Curated
Keywords - Domaini
RepeatPhylogenomic databases
HOGENOMi | CLU_000604_92_3_11 |
OMAi | CPEERKT |
PhylomeDBi | Q8G847 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q8G847-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDKNPIVVM KGITIEFPGV KALDGVDLTL YPGEVHALMG ENGAGKSTMI
60 70 80 90 100
KALTGVYKIN AGSIMVDGKP QQFNGTLDAQ NAGIATVYQE VNLCTNLSVG
110 120 130 140 150
ENVMLGHEKR GPFGIDWKKT HEAAKKYLAQ MGLESIDPHT PLSSISIAMQ
160 170 180 190 200
QLVAIARAMV INAKVLILDE PTSSLDANEV RDLFAIMRKV RDSGVAILFV
210 220 230 240 250
SHFLDQIYEI TDRLTILRNG QFIKEVMTKD TPRDELIGMM IGKSAAELSQ
260 270 280 290 300
IGAKKARREI TPGEKPIVDV KGLGKKGTIN PVDVDIYKGE VVGFAGLLGS
310 320 330 340 350
GRTELGRLLY GADKPDSGTY TLNGKKVNIS DPYTALKNKI AYSTENRRDE
360 370 380 390 400
GIIGDLTVRQ NILIALQATR GMFKPIPKKE ADAIVDKYMK ELNVRPADPD
410 420 430 440 450
RPVKNLSGGN QQKVLIGRWL ATHPELLILD EPTRGIDIGA KAEIQQVVLD
460 470 480 490 500
LASQGMGVVF ISSELEEVVR LSDDIEVLKD RHKIAEIEND DTVSQATIVE
510
TIANTNVNTG KEA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014295 Genomic DNA Translation: AAN23901.1 |
RefSeqi | NP_695265.1, NC_004307.2 WP_007053223.1, NC_004307.2 |
Genome annotation databases
EnsemblBacteriai | AAN23901; AAN23901; BL0034 |
KEGGi | blo:BL0034 |
PATRICi | fig|206672.9.peg.36 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014295 Genomic DNA Translation: AAN23901.1 |
RefSeqi | NP_695265.1, NC_004307.2 WP_007053223.1, NC_004307.2 |
3D structure databases
SMRi | Q8G847 |
ModBasei | Search... |
Protein family/group databases
TCDBi | 3.A.1.2.23, the atp-binding cassette (abc) superfamily |
Genome annotation databases
EnsemblBacteriai | AAN23901; AAN23901; BL0034 |
KEGGi | blo:BL0034 |
PATRICi | fig|206672.9.peg.36 |
Phylogenomic databases
HOGENOMi | CLU_000604_92_3_11 |
OMAi | CPEERKT |
PhylomeDBi | Q8G847 |
Enzyme and pathway databases
BioCyci | BLON206672:G1FZZ-34-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FRUK_BIFLO | |
Accessioni | Q8G847Primary (citable) accession number: Q8G847 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2017 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families