UniProtKB - Q8G846 (FRUF_BIFLO)
Protein
Fructose import permease protein FruF
Gene
fruF
Organism
Bifidobacterium longum (strain NCC 2705)
Status
Functioni
Part of the high-affinity ABC transporter complex FruEKFG involved in fructose uptake. Can also transport ribose and xylose, with lower affinity. Probably responsible for the translocation of the substrate across the membrane.1 Publication
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
Keywordsi
Biological process | Sugar transport, Transport |
Enzyme and pathway databases
BioCyci | BLON206672:G1FZZ-35-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.2.23, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Fructose import permease protein FruFCurated |
Gene namesi | Name:fruF1 Publication Ordered Locus Names:BL0035Imported |
Organismi | Bifidobacterium longum (strain NCC 2705) |
Taxonomic identifieri | 206672 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium › |
Proteomesi |
|
Subcellular locationi
- Cell membrane Curated; Multi-pass membrane protein Sequence analysis
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 25 – 45 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 113 – 133 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 180 – 200 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 231 – 251 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 268 – 290 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 308 – 328 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000439270 | 1 – 356 | Fructose import permease protein FruFAdd BLAST | 356 |
Interactioni
Subunit structurei
The complex is composed of an ATP-binding protein (FruK), two transmembrane proteins (FruF and FruG) and a solute-binding protein (FruE).
1 PublicationFamily & Domainsi
Sequence similaritiesi
Belongs to the binding-protein-dependent transport system permease family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_028880_3_0_11 |
OMAi | VWNGFLV |
PhylomeDBi | Q8G846 |
Family and domain databases
InterProi | View protein in InterPro IPR001851, ABC_transp_permease |
Pfami | View protein in Pfam PF02653, BPD_transp_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8G846-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEKAKAEGN NFVKKLLSSN LTWSIVAFIL LVIICTIFQH DFLALSWNSN
60 70 80 90 100
TGGLAGPLIT MLQESARYLM IATGMTLVIS TAGIDLSVGS VMAVAGAAAM
110 120 130 140 150
QTLSNGMNVW LSILIALAVG LAIGCVNGAL VSFLGLQPFI TTLIMMLAGR
160 170 180 190 200
GMAKVITSGE NTDASAVAGN EPLKWFANGF ILGIPANFVI AVIIVILVGL
210 220 230 240 250
LCRKTAMGMM IEAVGINQEA SRMTGIKPKK ILFLVYAISG FLAAIAGLFA
260 270 280 290 300
TASVMRVDVV KTGQDLEMYA ILAVVIGGTS LLGGKFSLAG SAVGAVIIAM
310 320 330 340 350
IRKTIITLGV NAEATPAFFA VVVIVICVMQ APKIHNLSAN MKRKRALKAQ
AKAVAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014295 Genomic DNA Translation: AAN23902.1 |
RefSeqi | NP_695266.1, NC_004307.2 WP_007053224.1, NC_004307.2 |
Genome annotation databases
EnsemblBacteriai | AAN23902; AAN23902; BL0035 |
KEGGi | blo:BL0035 |
PATRICi | fig|206672.9.peg.37 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014295 Genomic DNA Translation: AAN23902.1 |
RefSeqi | NP_695266.1, NC_004307.2 WP_007053224.1, NC_004307.2 |
3D structure databases
SMRi | Q8G846 |
ModBasei | Search... |
Protein family/group databases
TCDBi | 3.A.1.2.23, the atp-binding cassette (abc) superfamily |
Genome annotation databases
EnsemblBacteriai | AAN23902; AAN23902; BL0035 |
KEGGi | blo:BL0035 |
PATRICi | fig|206672.9.peg.37 |
Phylogenomic databases
HOGENOMi | CLU_028880_3_0_11 |
OMAi | VWNGFLV |
PhylomeDBi | Q8G846 |
Enzyme and pathway databases
BioCyci | BLON206672:G1FZZ-35-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR001851, ABC_transp_permease |
Pfami | View protein in Pfam PF02653, BPD_transp_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FRUF_BIFLO | |
Accessioni | Q8G846Primary (citable) accession number: Q8G846 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2017 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families