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Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene namesi
Name:hisC
Ordered Locus Names:CE2002
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001409 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001533491 – 372Histidinol-phosphate aminotransferaseAdd BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi196164.HMPREF0290_2034

Structurei

3D structure databases

ProteinModelPortaliQ8FNZ1
SMRiQ8FNZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH Bacteria
COG0079 LUCA
HOGENOMiHOG000288510
KOiK00817
OMAiTYGMYKV
OrthoDBiPOG091H05S1

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8FNZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDTTLAPEV TLSDLPLREE LRGESAYGAP QLNVSVRLNT NENPYPPSEA
60 70 80 90 100
LIADLVETVR ATATELNRYP ERDSVELRDA LADYITHQTG VQVTRENLWA
110 120 130 140 150
ANGSNEVLQQ LLQAFGGPGR KALGFQPSYS MHPILSKGTQ TEFIAIPRGA
160 170 180 190 200
DFRIDMDAAL AAIEEHVPDI IFVTTPNNPT GDITSLADIE KIINAAPGIV
210 220 230 240 250
IVDEAYAEFS PSPSATTLIT RYPAKLVVSR TMSKAFDFAG GRLGYFVAAP
260 270 280 290 300
AFIEAVMLVR LPYHLSALSQ AAATVALRHR DDTLATVAKL SSERIRVAAR
310 320 330 340 350
LEELGYTQVP SESNFIFFGK FTDQHTAWEA FLDRGVLIRD VGVSGHLRVT
360 370
IGLPEENDSF LAAAAEISGL NL
Length:372
Mass (Da):40,411
Last modified:March 1, 2003 - v1
Checksum:i68F7CFF8DBE13519
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA Translation: BAC18812.1
RefSeqiWP_006768000.1, NZ_GG700683.1

Genome annotation databases

EnsemblBacteriaiBAC18812; BAC18812; BAC18812
KEGGicef:CE2002

Similar proteinsi

Entry informationi

Entry nameiHIS8_COREF
AccessioniPrimary (citable) accession number: Q8FNZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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