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Protein

Crotonobetaine/carnitine--CoA ligase

Gene

caiC

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.UniRule annotation

Catalytic activityi

ATP + 4-(trimethylamino)butanoate + CoA = AMP + diphosphate + gamma-butyrobetainyl-CoA.UniRule annotation
ATP + crotonobetaine + CoA = AMP + diphosphate + crotonobetainyl-CoA.UniRule annotation
ATP + L-carnitine + CoA = AMP + diphosphate + L-carnitinyl-CoA.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase

Enzyme and pathway databases

UniPathwayi
UPA00117

Names & Taxonomyi

Protein namesi
Recommended name:
Crotonobetaine/carnitine--CoA ligaseUniRule annotation (EC:6.2.1.48UniRule annotation)
Gene namesi
Name:caiCUniRule annotation
Ordered Locus Names:c0046
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001930661 – 517Crotonobetaine/carnitine--CoA ligaseAdd BLAST517

Interactioni

Protein-protein interaction databases

STRINGi199310.c0046

Structurei

3D structure databases

ProteinModelPortaliQ8FLA5
SMRiQ8FLA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEY Bacteria
COG0318 LUCA
HOGENOMiHOG000230001
KOiK02182

Family and domain databases

HAMAPiMF_01524 CaiC, 1 hit
InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR023456 CaiC
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q8FLA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIIGGQHLR QMWDDLADVY GHKTALICES SSGVVNRYSY LELNQEINRT
60 70 80 90 100
ANLFYTLGIR KGDKVALHLD NCPEFIFCWF GLAKIGAIMV PINARLLREE
110 120 130 140 150
STWILQNSQA CLLVTSAQFY PMYQQIQQED ASQLRHICLT DMVLPADDGV
160 170 180 190 200
SSFTQLKNQQ PATLCYAPPL STDDTAEILF TSGTTSRPKG VVITHYNLRF
210 220 230 240 250
AGYYSAWQCA LRDDDVYLTV MPAFHIDCQC TAAMAAFSAG ATFVLVEKYS
260 270 280 290 300
ARAFWGQVQK YRATITECIP MMIRTLMVQP LSANDQQHRL REVMFYLNLS
310 320 330 340 350
EQEKDAFCER FSVRLLTSYG MTETIVGIIG DRPGDKRRWP SIGRAGFCYE
360 370 380 390 400
AEIRDDHNRP LPAGELGEIC IKGVPGKTIF KEYFLNPKAT AKVLEADGWL
410 420 430 440 450
HTGDTGYRDE EGFFYFVDRR CNMIKRGGEN VSCVELENII ATHPKIQDIV
460 470 480 490 500
VVGIKDSIRD EAIKAFVVLN EGETLSEEEF FCFCEQNMAK FKVPSYLEIR
510
KDLPRNCSGK IIRKNLK
Length:517
Mass (Da):58,655
Last modified:August 21, 2007 - v2
Checksum:iC66E32D6A3BD27F6
GO

Sequence cautioni

The sequence AAN78544 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA Translation: AAN78544.1 Different initiation.
RefSeqiWP_001298634.1, NC_004431.1

Genome annotation databases

EnsemblBacteriaiAAN78544; AAN78544; c0046
KEGGiecc:c0046

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA Translation: AAN78544.1 Different initiation.
RefSeqiWP_001298634.1, NC_004431.1

3D structure databases

ProteinModelPortaliQ8FLA5
SMRiQ8FLA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi199310.c0046

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN78544; AAN78544; c0046
KEGGiecc:c0046

Phylogenomic databases

eggNOGiENOG4105CEY Bacteria
COG0318 LUCA
HOGENOMiHOG000230001
KOiK02182

Enzyme and pathway databases

UniPathwayi
UPA00117

Family and domain databases

HAMAPiMF_01524 CaiC, 1 hit
InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR023456 CaiC
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAIC_ECOL6
AccessioniPrimary (citable) accession number: Q8FLA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: August 21, 2007
Last modified: February 28, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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