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Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumUniRule annotation1
Metal bindingi58MagnesiumUniRule annotation1

GO - Molecular functioni

  • holo-[acyl-carrier-protein] synthase activity Source: TIGR
  • magnesium ion binding Source: InterPro

GO - Biological processi

  • fatty acid biosynthetic process Source: UniProtKB-KW
  • lipid biosynthetic process Source: TIGR

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciSONE211586:G1GMP-1250-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:acpSUniRule annotation
Ordered Locus Names:SO_1352
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001756971 – 127Holo-[acyl-carrier-protein] synthaseAdd BLAST127

Proteomic databases

PaxDbiQ8EH77

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_1352

Structurei

3D structure databases

ProteinModelPortaliQ8EH77
SMRiQ8EH77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KJV Bacteria
COG0736 LUCA
HOGENOMiHOG000014316
KOiK00997
OMAiDERHYAV
OrthoDBiPOG091H0071
PhylomeDBiQ8EH77

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00516 acpS, 1 hit
TIGR00556 pantethn_trn, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EH77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVGLGTDI VEIERISAHV ARSGDKLAKR VLTEAEFEIY QQHSQPSRYL
60 70 80 90 100
AKRFAAKEAA AKALGTGIGR GVSFQHIHIG NTPDGAPTID FTEGAQQRLT
110 120
LLNGVVGHIS IADEKSYAIA TVILESR
Length:127
Mass (Da):13,639
Last modified:March 1, 2003 - v1
Checksum:i6CA5CC686C50F2A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA Translation: AAN54417.1
RefSeqiNP_716972.1, NC_004347.2
WP_011071561.1, NC_004347.2

Genome annotation databases

EnsemblBacteriaiAAN54417; AAN54417; SO_1352
GeneIDi1169173
KEGGison:SO_1352
PATRICifig|211586.12.peg.1301

Similar proteinsi

Entry informationi

Entry nameiACPS_SHEON
AccessioniPrimary (citable) accession number: Q8EH77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health