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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61SubstrateUniRule annotation1
Binding sitei69SubstrateUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Sitei175Important for catalytic activityUniRule annotation1
Active sitei177Proton donor/acceptorUniRule annotation1
Active sitei249NucleophileUniRule annotation1

GO - Molecular functioni

  • beta-N-acetylhexosaminidase activity Source: TIGR
  • N-acetyl-beta-D-galactosaminidase activity Source: UniProtKB-EC

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSONE211586:G1GMP-2055-MONOMER
UniPathwayiUPA00544

Protein family/group databases

CAZyiGH3 Glycoside Hydrolase Family 3

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:SO_2250
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002107981 – 342Beta-hexosaminidaseAdd BLAST342

Proteomic databases

PaxDbiQ8EEW2

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_2250

Structurei

3D structure databases

ProteinModelPortaliQ8EEW2
SMRiQ8EEW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 165Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QPA Bacteria
COG1472 LUCA
HOGENOMiHOG000248526
KOiK01207
OMAiHKETPRD
OrthoDBiPOG091H039J
PhylomeDBiQ8EEW2

Family and domain databases

Gene3Di3.20.20.300, 1 hit
HAMAPiMF_00364 NagZ, 1 hit
InterProiView protein in InterPro
IPR022956 Beta_hexosaminidase_bac
IPR019800 Glyco_hydro_3_AS
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00933 Glyco_hydro_3, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00775 GLYCOSYL_HYDROL_F3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8EEW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYLMLDLLS LDVSEAEAEM LRHPQVGGLI LFSRNFTSRE QLIALVQQIR
60 70 80 90 100
QIRPEILIAV DHEGGRVQRF REGFTLIPAM GDILPAAKGD MALAKRWACE
110 120 130 140 150
LGFLMAIELL ACDIDLSFAP VLDLNGISQV IGKRSFSANP DEVIALARSF
160 170 180 190 200
IEGMAQAGMG AVGKHFPGHG SVAADSHIAQ PIDEREGEVI FNQDILPFKE
210 220 230 240 250
LIFNGKLSGI MPAHVIYPKV DPNPAGFSSY WLKQILRKEL GFNGVIFSDD
260 270 280 290 300
LGMKGASFAG DYVGRAKAAL DAGCDMILVC NDNPGVMTLL NGFVWPEAAP
310 320 330 340
QHPASLLKPN MAQTALALEN SARWENAKQL AEQIQLAQQA KV
Length:342
Mass (Da):37,193
Last modified:March 1, 2003 - v1
Checksum:iAB603E9104D16065
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA Translation: AAN55290.1
RefSeqiNP_717846.1, NC_004347.2
WP_011072263.1, NC_004347.2

Genome annotation databases

EnsemblBacteriaiAAN55290; AAN55290; SO_2250
GeneIDi1169981
KEGGison:SO_2250
PATRICifig|211586.12.peg.2166

Similar proteinsi

Entry informationi

Entry nameiNAGZ_SHEON
AccessioniPrimary (citable) accession number: Q8EEW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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