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Protein

Chemotaxis response regulator protein-glutamate methylesterase of group 1 operon

Gene

cheB1

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei193UniRule annotation1
Active sitei220UniRule annotation1
Active sitei316UniRule annotation1

GO - Molecular functioni

  • phosphorelay response regulator activity Source: InterPro
  • protein-glutamate methylesterase activity Source: TIGR

GO - Biological processi

  • chemotaxis Source: TIGR

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Enzyme and pathway databases

BioCyciSONE211586:G1GMP-2986-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase of group 1 operonUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB1UniRule annotation
Synonyms:cheB3
Ordered Locus Names:SO_3206
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001580281 – 374Chemotaxis response regulator protein-glutamate methylesterase of group 1 operonAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8ECD7

Interactioni

Protein-protein interaction databases

STRINGi211586.SO_3206

Structurei

3D structure databases

ProteinModelPortaliQ8ECD7
SMRiQ8ECD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini174 – 374CheB-type methylesteraseUniRule annotationAdd BLAST201

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP Bacteria
COG2201 LUCA
HOGENOMiHOG000151424
KOiK03412
OMAiYGMPMAV
OrthoDBiPOG091H045J
PhylomeDBiQ8ECD7

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ECD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKVLVVDD SSFFRRRVSE IVNQDPELEV IATASNGAEA VKMTADLNPQ
60 70 80 90 100
VITMDIEMPV MDGITAVREI MAKCPTPILM FSSLTHDGAK ATLDALDAGA
110 120 130 140 150
LDFLPKRFED IATNKDEAIL LLQQRVKALG RRRIFRPITR PSVAPVTPRP
160 170 180 190 200
TTGSAVGNAT TPVQSASAPV RSSPLSSIRA SGKQYKLLLI GTSTGGPVAL
210 220 230 240 250
QKVLTQFPAN YPHPILLIQH MPAAFTPAFA SRLNGLCKIE VKEAANGDIL
260 270 280 290 300
RPGCAYLAPG GMQMMVERAG VTGRIKVLAG SAEMNYKPCV DITFASASKA
310 320 330 340 350
YGGDVLAVVL TGMGADGREG ARMLKAAGAT IWAQDEASCV VYGMPQAVAS
360 370
TGIATQSISL DNMAESILKE SARG
Length:374
Mass (Da):39,484
Last modified:March 1, 2003 - v1
Checksum:i8F58AC58392B3D0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA Translation: AAN56205.1
RefSeqiNP_718761.1, NC_004347.2
WP_011073092.1, NC_004347.2

Genome annotation databases

EnsemblBacteriaiAAN56205; AAN56205; SO_3206
GeneIDi1170899
KEGGison:SO_3206
PATRICifig|211586.12.peg.3112

Similar proteinsi

Entry informationi

Entry nameiCHEB1_SHEON
AccessioniPrimary (citable) accession number: Q8ECD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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