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Entry version 105 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Octaheme tetrathionate reductase Otr

Gene

otr

Organism
Shewanella oneidensis (strain MR-1)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi22Iron (heme 1 axial ligand); via tele nitrogenCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei40Heme 1 (covalent)Combined sources1
Metal bindingi44Iron (heme 1 axial ligand); via tele nitrogenCombined sources1
Metal bindingi56Iron (heme 3 axial ligand); via tele nitrogenCombined sources1
Metal bindingi74Iron (heme 4 axial ligand)Combined sources1
Binding sitei95Heme 4 (covalent)Combined sources1
Binding sitei116Heme 2 (covalent)Combined sources1
Metal bindingi120Iron (heme 2 axial ligand); via tele nitrogenCombined sources1
Binding sitei157Heme 3 (covalent)Combined sources1
Binding sitei160Heme 3 (covalent)Combined sources1
Metal bindingi161Iron (heme 3 axial ligand); via tele nitrogenCombined sources1
Metal bindingi189Iron (heme 6 axial ligand); via tele nitrogenCombined sources1
Binding sitei199Heme 5 (covalent)Combined sources1
Binding sitei202Heme 5 (covalent)Combined sources1
Metal bindingi203Iron (heme 5 axial ligand); via tele nitrogenCombined sources1
Metal bindingi208Iron (heme 2 axial ligand); via tele nitrogenCombined sources1
Binding sitei227Heme 6 (covalent)Combined sources1
Binding sitei230Heme 6 (covalent)Combined sources1
Metal bindingi231Iron (heme 6 axial ligand); via tele nitrogenCombined sources1
Metal bindingi236Iron (heme 7 axial ligand); via tele nitrogenCombined sources1
Metal bindingi244Iron (heme 8 axial ligand); via tele nitrogenCombined sources1
Binding sitei250Heme 7 (covalent)Combined sources1
Binding sitei253Heme 7 (covalent)Combined sources1
Metal bindingi254Iron (heme 7 axial ligand); via tele nitrogenCombined sources1
Metal bindingi418Iron (heme 5 axial ligand); via tele nitrogenCombined sources1
Binding sitei429Heme 8 (covalent)Combined sources1
Binding sitei432Heme 8 (covalent)Combined sources1
Metal bindingi433Iron (heme 8 axial ligand); via tele nitrogenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transportARBA annotation, Transport
LigandHemeCombined sourcesARBA annotation, Iron, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Octaheme tetrathionate reductase OtrImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:otrImported
Ordered Locus Names:SO_4144Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiShewanella oneidensis (strain MR-1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri211586 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008186 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500430708019 – 461Sequence analysisAdd BLAST443

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8E9W8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
211586.SO_4144

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8E9W8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8E9W8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 259MULTIHEME_CYTCInterPro annotationAdd BLAST225
Domaini424 – 438MULTIHEME_CYTCInterPro annotationAdd BLAST15

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502Z8B5, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_033148_0_0_6

Identification of Orthologs from Complete Genome Data

More...
OMAi
NCGTCHF

Database of Orthologous Groups

More...
OrthoDBi
738283at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023155, Cyt_c-552/4
IPR011031, Multihaem_cyt
IPR036280, Multihaem_cyt_sf
IPR024673, Octahem_Cyt_c

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13435, Cytochrome_C554, 1 hit
PF11783, Cytochrome_cB, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF039014, OTR_cyc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48695, SSF48695, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04315, octaheme_Shew, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51008, MULTIHEME_CYTC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8E9W8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQLLFIALA GMALQAQAAN PHKDVLKGPF TTGSEVTTQC LTCHEEQATD
60 70 80 90 100
MMKTSHWTWE LEQKLPDRTV VRGKKNSINN FCVAISSNEP RCTSCHAGYG
110 120 130 140 150
WKDNTFDFKD KTKVDCLICH DTTGTYVKDP AGAGEPMAKL DLAKIAQNVG
160 170 180 190 200
APVRDNCGSC HFYGGGGDAV KHGDLDSSMA YPDKATDVHM DSDGNNFQCQ
210 220 230 240 250
NCHTTEKHQI SGNAMGVSPG GIDHIGCENC HDSAPHSNKK LNTHTATVAC
260 270 280 290 300
QTCHIPFFAK NEPTKMQWDW STAGDDKPET VDQYGKHTYQ KKKGNFVWEK
310 320 330 340 350
MVKPQYAWYN GTANAYMAGD KMDSNVVTKL TYPMGDINDA KAKIYPFKVH
360 370 380 390 400
TGKQIYDKKL NIFITPKTYG KGGYWSEFDW NLAAKLGMEA NPTMLEKGIK
410 420 430 440 450
YSGEYDFAAT EMWWRINHMV SPKEQALNCN DCHNKGTRLD WQALGYQGDP
460
MKNKQGPKHK Q
Length:461
Mass (Da):51,400
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DC5C74CF0AAA73D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014299 Genomic DNA Translation: AAN57117.1

NCBI Reference Sequences

More...
RefSeqi
NP_719673.1, NC_004347.2
WP_011073841.1, NZ_CP053946.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
son:SO_4144

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|211586.12.peg.4006

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014299 Genomic DNA Translation: AAN57117.1
RefSeqiNP_719673.1, NC_004347.2
WP_011073841.1, NZ_CP053946.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SP3X-ray2.20A19-461[»]
SMRiQ8E9W8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi211586.SO_4144

Proteomic databases

PaxDbiQ8E9W8

Genome annotation databases

KEGGison:SO_4144
PATRICifig|211586.12.peg.4006

Phylogenomic databases

eggNOGiENOG502Z8B5, Bacteria
HOGENOMiCLU_033148_0_0_6
OMAiNCGTCHF
OrthoDBi738283at2

Miscellaneous databases

EvolutionaryTraceiQ8E9W8

Family and domain databases

InterProiView protein in InterPro
IPR023155, Cyt_c-552/4
IPR011031, Multihaem_cyt
IPR036280, Multihaem_cyt_sf
IPR024673, Octahem_Cyt_c
PfamiView protein in Pfam
PF13435, Cytochrome_C554, 1 hit
PF11783, Cytochrome_cB, 1 hit
PIRSFiPIRSF039014, OTR_cyc, 1 hit
SUPFAMiSSF48695, SSF48695, 1 hit
TIGRFAMsiTIGR04315, octaheme_Shew, 1 hit
PROSITEiView protein in PROSITE
PS51008, MULTIHEME_CYTC, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8E9W8_SHEON
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8E9W8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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