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UniProtKB - Q8E473 (Q8E473_STRA3)

Entry version 115 (02 Dec 2020)
Sequence version 1 (01 Mar 2003)
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Protein

GRAM_POS_ANCHORING domain-containing protein

Gene

gbs1529

Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi349CalciumCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumCombined sources, Metal-bindingCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRAM_POS_ANCHORING domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:gbs1529Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus agalactiae serotype III (strain NEM316)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri211110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000823 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell wallPROSITE-ProRule annotationARBA annotation, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...PHI-basei		PHI:3269

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_50183518511278 – 1310Removed by sortasePROSITE-ProRule annotationAdd BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1277Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchorPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		211110.gbs1529

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8E473

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1274 – 1310GRAM_POS_ANCHORINGInterPro annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni119 – 158DisorderedSequence analysisAdd BLAST40
Regioni177 – 196DisorderedSequence analysisAdd BLAST20
Regioni688 – 707DisorderedSequence analysisAdd BLAST20
Regioni722 – 771DisorderedSequence analysisAdd BLAST50
Regioni842 – 903DisorderedSequence analysisAdd BLAST62
Regioni966 – 991DisorderedSequence analysisAdd BLAST26
Regioni1078 – 1115DisorderedSequence analysisAdd BLAST38
Regioni1240 – 1279DisorderedSequence analysisAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1274 – 1278LPXTG sorting signalPROSITE-ProRule annotation5

Keywords - Domaini

SignalARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG5295, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009623_0_0_9

Identification of Orthologs from Complete Genome Data

More...OMAi		NQTGMAT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.1280, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011266, Adhesin_Fg-bd_dom_2
IPR008966, Adhesion_dom_sf
IPR011252, Fibrogen-bd_dom1
IPR019948, Gram-positive_anchor
IPR022263, KxYKxGKxW
IPR019931, LPXTG_anchor
IPR041171, SDR_Ig
IPR026465, Ser_adhes_glycop

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17961, Big_8, 1 hit
PF00746, Gram_pos_anchor, 1 hit
PF10425, SdrG_C_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49401, SSF49401, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR03715, KxYKxGKxW, 1 hit
TIGR04224, ser_adhes_Nterm, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50847, GRAM_POS_ANCHORING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8E473-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQKTFGKQL TVVDTKSRVK MHKSGKNWVR TVMSHFNLFK AIKGRATVEA 
        60         70         80         90        100
DVCIQDVEKE DRLSSGNLTY LKGILAAGAL VGGASLTSRV YADETPVVQE 
       110        120        130        140        150
QSSSVPTLAE QTEVTVKTTT VQNHQDGTVS KNIIDSNSVS MSESASTSTS 
       160        170        180        190        200
ESVSMSMSGS TLTSVSESVS TSALTSASES ISTSASESVS KSTSISEVSN 
       210        220        230        240        250
ILETQASLTD KGRESFSANQ IVTESSLVTD AGKNASVSSL IEITKPKSEL 
       260        270        280        290        300
QTSKMSNESL ITPEKSQVMI ASDKTGNESL TPTIRLKSVI QPRSMNLMTL 
       310        320        330        340        350
SSEMDLIPLE EVSDTEMLGK DVSSELQKVN IALKDNTLSE PGTVKLDSSE 
       360        370        380        390        400
NLVLNFAFSI ASVNEGDVFT VKLSDNLDTQ GIGTILKVQD IMDETGQLLA 
       410        420        430        440        450
TGSYSPLTHN ITYTWTRYAS TLNNIKARVN MPVWPDQRII SKTTSDKQCF 
       460        470        480        490        500
TATLNNQVAS IEERVQYNSP SVTEHTNVKT NVRSRIMKLD DERQTETYIT 
       510        520        530        540        550
QINPEGKEMY FASGLGNLYT IIGSDGTSGS PVNLLNAEVK ILKTNSKNLT 
       560        570        580        590        600
DSMDQNYDSP EFEDVTSQYS YTNDGSKITI DWKTNSISST TSYVVLVKIP 
       610        620        630        640        650
KQSGVLYSTV SDINQTYGSK YSYGHTNISG DSDANAEIKL LSESASTSAS 
       660        670        680        690        700
TSASTSASMS ASTSASTSAS MSASTSASTS ASMSASTSAS TSASTSTSTS 
       710        720        730        740        750
ASTSASTSAS TSASMSASTS ASTSASTSAS TSASTSASTS ASTSASTSAS 
       760        770        780        790        800
TSASTSASTS ASTSASTSAS TSASTSASMS ASMSASTSAS MSASTSASTS 
       810        820        830        840        850
ASTSASTSAS TSASTSASMS ASTSASTSAS TSASMSASTS ASTSASTSAS 
       860        870        880        890        900
TSASTSTSTS ASTSASTSAS TSASMSASTS ASTSPSTSAS TSASTSASTS 
       910        920        930        940        950
ASTSASTSAS MSASTSASTS ASMSASTSAS TSASTSASTS ASMSASTSAS 
       960        970        980        990       1000
TSASTSASMS ASTSASTSAS TSASTSASTS TSTSASTSAS TSASTSASMS 
      1010       1020       1030       1040       1050
ASTSASTSAS TSASMSASTS ASISASTSAS MSASTSASTS ASTSASTSAS 
      1060       1070       1080       1090       1100
MSASTSASTS ASTSASTSAS MSASTSASTS ASTSASTSAS TSASTSASTS 
      1110       1120       1130       1140       1150
ASTSSSTSAS TSASTSASTS ASMSASTSAS TSASMSASTS ASTSASTSAS 
      1160       1170       1180       1190       1200
MSASTSSSTS ASMSASTSAS MSASTSASTS ASTSASMSAS TSSSTSASMS 
      1210       1220       1230       1240       1250
ASTSASMSAS TSASTSASTS ASMSASTSAS MSATTSASTS VSTSASTSAS 
      1260       1270       1280       1290       1300
TSASTSSSSS VTSNSSKEKV YSALPSTGDQ DYSVTATALG LGLMTGATLL 
      1310
GRKKSKKDKD
Length:1,310
Mass (Da):129,398
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FB7A8BE89B8F155
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL766851 Genomic DNA Translation: CAD47188.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CAD47188; CAD47188; CAD47188

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		san:gbs1529

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL766851 Genomic DNA Translation: CAD47188.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MBOX-ray1.65A311-641[»]
4RMBX-ray1.70A/B485-642[»]
SMRiQ8E473
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi211110.gbs1529

Genome annotation databases

EnsemblBacteriaiCAD47188; CAD47188; CAD47188
KEGGisan:gbs1529

Phylogenomic databases

eggNOGiCOG5295, Bacteria
HOGENOMiCLU_009623_0_0_9
OMAiNQTGMAT

Miscellaneous databases

PHI-baseiPHI:3269

Family and domain databases

Gene3Di2.60.40.1280, 1 hit
InterProiView protein in InterPro
IPR011266, Adhesin_Fg-bd_dom_2
IPR008966, Adhesion_dom_sf
IPR011252, Fibrogen-bd_dom1
IPR019948, Gram-positive_anchor
IPR022263, KxYKxGKxW
IPR019931, LPXTG_anchor
IPR041171, SDR_Ig
IPR026465, Ser_adhes_glycop
PfamiView protein in Pfam
PF17961, Big_8, 1 hit
PF00746, Gram_pos_anchor, 1 hit
PF10425, SdrG_C_C, 1 hit
SUPFAMiSSF49401, SSF49401, 2 hits
TIGRFAMsiTIGR03715, KxYKxGKxW, 1 hit
TIGR04224, ser_adhes_Nterm, 1 hit
PROSITEiView protein in PROSITE
PS50847, GRAM_POS_ANCHORING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8E473_STRA3
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8E473
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: December 2, 2020
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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