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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei599For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciSAGA208435:G1FZP-1036-MONOMER

Protein family/group databases

MEROPSiC44.A08

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:SAG0944
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000821 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353882 – 604Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST603

Proteomic databases

PRIDEiQ8DZZ7

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8DZZ7
SMRiQ8DZZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2UniRule annotationAdd BLAST217
Domaini284 – 423SIS 1UniRule annotationAdd BLAST140
Domaini456 – 594SIS 2UniRule annotationAdd BLAST139

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8DZZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGVVGN TNATDILIQG LEKLEYRGYD SAGIFVVGDN KSQLVKSVGR
60 70 80 90 100
IAEIQAKVGD SVSGTTGIGH TRWATHGKPT EGNAHPHTSG SGRFVLVHNG
110 120 130 140 150
VIENYLQIKE TYLTKHNLKG ETDTEIAIHL VEHFVEEDNL SVLEAFKKAL
160 170 180 190 200
HIIEGSYAFA LIDSQDADTI YVAKNKSPLL IGLGNGYNMV CSDAMAMIRE
210 220 230 240 250
TSEYMEIHDK ELVIVKKDSV EVQDYDGNVI ERGSYTAELD LSDIGKGTYP
260 270 280 290 300
FYMLKEIDEQ PTVMRKLIST YANESGDMNV DSDIIKSVQE ADRLYILAAG
310 320 330 340 350
TSYHAGFAAK TMIEKLTDTP VELGVSSEWG YNMPLLSKKP MFILLSQSGE
360 370 380 390 400
TADSRQVLVK ANEMGIPSLT ITNVPGSTLS REATYTMLIH AGPEIAVAST
410 420 430 440 450
KAYTAQVATL AFLAKAVGEA NGKAEAKDFD LVHELSIVAQ SIEATLSEKD
460 470 480 490 500
VISEKVEQLL ISTRNAFYIG RGNDYYVTME AALKLKEISY IQTEGFAAGE
510 520 530 540 550
LKHGTISLIE DNTPVIALIS ADSTIAAHTR GNIQEVVSRG ANALIIVEEG
560 570 580 590 600
LEREGDDIIV NKVHPFLSAI SMVIPTQLIA YYASLQRGLD VDKPRNLAKA

VTVE
Length:604
Mass (Da):65,636
Last modified:January 23, 2007 - v3
Checksum:i65DD68D81B4741E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009948 Genomic DNA Translation: AAM99828.1
RefSeqiNP_687956.1, NC_004116.1
WP_000334314.1, NC_004116.1

Genome annotation databases

EnsemblBacteriaiAAM99828; AAM99828; SAG0944
GeneIDi1013748
KEGGisag:SAG0944
PATRICifig|208435.3.peg.949

Entry informationi

Entry nameiGLMS_STRA5
AccessioniPrimary (citable) accession number: Q8DZZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 94 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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