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Entry version 108 (02 Dec 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Urocanate reductase

Gene

urdA

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the two-electron reduction of urocanate to dihydrourocanate (also named imidazole propionate or deamino-histidine). Dihydrourocanate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria S.mutans strain UA159 may contribute to the pathogenesis of type 2 diabetes by producing the microbial metabolite dihydrourocanate.

1 Publication

Miscellaneous

S.mutans strain UA159 is significantly more abundant in subjects with type 2 diabetes (T2D) compared with subjects with normal glucose tolerance (NGT).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei311FAD; via amide nitrogenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei632Proton donorBy similarity1
Binding sitei768FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi330 – 331FADBy similarity2
Nucleotide bindingi338 – 345FADBy similarity8
Nucleotide bindingi783 – 784FADBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, FMN

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SMUT210007:G1FZX-185-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Urocanate reductase1 Publication (EC:1.3.99.33By similarity1 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:urdA1 Publication
Ordered Locus Names:SMU_180Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri210007 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002512 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004461041 – 803Urocanate reductaseAdd BLAST803

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8DW88

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
210007.SMU_180

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8DW88

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0431, Bacteria
COG1053, Bacteria
COG3976, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011398_4_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
THIPCWL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8DW88

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.360, 1 hit
3.50.50.60, 2 hits
3.90.700.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003953, FAD-binding_2
IPR036188, FAD/NAD-bd_sf
IPR010960, Flavocytochrome_c
IPR029039, Flavoprotein-like_sf
IPR007329, FMN-bd
IPR005025, FMN_Rdtase-like
IPR027477, Succ_DH/fumarate_Rdtase_cat_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00890, FAD_binding_2, 1 hit
PF04205, FMN_bind, 1 hit
PF03358, FMN_red, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00900, FMN_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905, SSF51905, 1 hit
SSF52218, SSF52218, 1 hit
SSF56425, SSF56425, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01813, flavo_cyto_c, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8DW88-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLIAIVGTN AKQSYNRILL QFMKRHFVQK ADIDIMEIAN VPMFNETEDQ
60 70 80 90 100
TDLPAIQNFN TKISQADGVI IATPEHNHTI PSSLNSLLEW LSFKVHPLDG
110 120 130 140 150
KPLMIVGASY DVQGSSRAQL HLRQILDAPG VNAAVMPGSE FLLGRAHQAF
160 170 180 190 200
DEAGNLKSEA TVDFLESCFF KFLRFVQVAN QLNEPEEVSF EAGTYQVTTQ
210 220 230 240 250
GHNGKLPMTV TLSEEKIEKI DIDSSGESSG IADIVFTRIP NEILEGQTLN
260 270 280 290 300
VDAVSGASVT SNGVLDGVAR AIKLAGGNPD VLRKRPKAPS ALDKEDKTYS
310 320 330 340 350
TDVVIVGGGG AGLAAAARVL QAGKQVMVLE KFPALGGNTV RSGGLLNAAD
360 370 380 390 400
PEWQKTFPAN PGEAHNLSEL IQTDEDSIAA EYLADFKELK QQVTNYLKDP
410 420 430 440 450
SYLFDSNILH RIQTYIGGKR TDRNGCEVYG NYDLVKVLTD KDLDSVHWLA
460 470 480 490 500
DIGVDFDRSE VSMPVGALWR RSHKPKQPMG YAFIEALDTY IRKNSGTILT
510 520 530 540 550
DTAVTDFILE NGLIKGVLAK GRNGQTITVH AQAVVLASGG FGANTKMLQQ
560 570 580 590 600
YNTYWSNIDD NIQTTNSPAI TGDGIRLGQS IGAALVGMGF SQMMPVSDPN
610 620 630 640 650
TGAIFSGLQV PPANFVMVNQ EGKRFVDEYG SRDTLSKAAI DNGGLFYLIA
660 670 680 690 700
DENIKATAMN TSNEKIEEQV AAGTLYRADT LESLAEQIGV DPATLVETIN
710 720 730 740 750
NYNSYVEAGY DPEFDKGAFD LKVEKAPFYA TPRKPATHHT MGGLKIDTQA
760 770 780 790 800
HVIKEDGNKI PSLYAAGEVT GGIHAGNRLG GNALADIFTF GRIAAETAVT

ECC
Length:803
Mass (Da):86,809
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1BF08F3E74FCAFB7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014133 Genomic DNA Translation: AAN57955.1

NCBI Reference Sequences

More...
RefSeqi
NP_720649.1, NC_004350.2
WP_002262027.1, NC_004350.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAN57955; AAN57955; SMU_180

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
smu:SMU_180

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|210007.7.peg.156

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA Translation: AAN57955.1
RefSeqiNP_720649.1, NC_004350.2
WP_002262027.1, NC_004350.2

3D structure databases

SMRiQ8DW88
ModBaseiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_180

Proteomic databases

PRIDEiQ8DW88

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1029753

Genome annotation databases

EnsemblBacteriaiAAN57955; AAN57955; SMU_180
KEGGismu:SMU_180
PATRICifig|210007.7.peg.156

Phylogenomic databases

eggNOGiCOG0431, Bacteria
COG1053, Bacteria
COG3976, Bacteria
HOGENOMiCLU_011398_4_0_9
OMAiTHIPCWL
PhylomeDBiQ8DW88

Enzyme and pathway databases

BioCyciSMUT210007:G1FZX-185-MONOMER

Family and domain databases

Gene3Di3.40.50.360, 1 hit
3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953, FAD-binding_2
IPR036188, FAD/NAD-bd_sf
IPR010960, Flavocytochrome_c
IPR029039, Flavoprotein-like_sf
IPR007329, FMN-bd
IPR005025, FMN_Rdtase-like
IPR027477, Succ_DH/fumarate_Rdtase_cat_sf
PfamiView protein in Pfam
PF00890, FAD_binding_2, 1 hit
PF04205, FMN_bind, 1 hit
PF03358, FMN_red, 1 hit
SMARTiView protein in SMART
SM00900, FMN_bind, 1 hit
SUPFAMiSSF51905, SSF51905, 1 hit
SSF52218, SSF52218, 1 hit
SSF56425, SSF56425, 1 hit
TIGRFAMsiTIGR01813, flavo_cyto_c, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiURDA_STRMU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8DW88
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2019
Last sequence update: March 1, 2003
Last modified: December 2, 2020
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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