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Entry version 124 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Phosphotransferase system sugar-specific EII component

Gene

PTS-EII

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei453Phosphocysteine intermediate; for EIIB activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseARBA annotation, Transferase
Biological processPhosphotransferase systemARBA annotation, Sugar transportARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Phosphotransferase system sugar-specific EII componentImported (EC:2.7.1.69Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTS-EIIImported
Ordered Locus Names:spr1528Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri171101 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000586 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei67 – 85HelicalSequence analysisAdd BLAST19
Transmembranei92 – 114HelicalSequence analysisAdd BLAST23
Transmembranei120 – 138HelicalSequence analysisAdd BLAST19
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei267 – 285HelicalSequence analysisAdd BLAST19
Transmembranei297 – 314HelicalSequence analysisAdd BLAST18
Transmembranei320 – 343HelicalSequence analysisAdd BLAST24
Transmembranei350 – 369HelicalSequence analysisAdd BLAST20
Transmembranei375 – 397HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
171101.spr1528

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8DNU7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 409PTS EIIC type-1InterPro annotationAdd BLAST406
Domaini431 – 510PTS EIIB type-1InterPro annotationAdd BLAST80

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1263, Bacteria
COG1264, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012312_1_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPIEYSF

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00212, PTS_IIB_glc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1360.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036878, Glu_permease_IIB
IPR018113, PTrfase_EIIB_Cys
IPR003352, PTS_EIIC
IPR013013, PTS_EIIC_1
IPR001996, PTS_IIB_1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00367, PTS_EIIB, 1 hit
PF02378, PTS_EIIC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55604, SSF55604, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00826, EIIB_glc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51098, PTS_EIIB_TYPE_1, 1 hit
PS01035, PTS_EIIB_TYPE_1_CYS, 1 hit
PS51103, PTS_EIIC_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8DNU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGSFMFKVL QKVGKAFMLP IAILPAAGLL LGIGGALSNP TTIATYPILD
60 70 80 90 100
NSIFQSIFQV MSSAGEVVFS NLSLLLCVGL CIGLAKRDKG TAALAGVTGY
110 120 130 140 150
LVMTATIKAL VKLFMAEGSA IDTGVIGALV VGIVAVYLHN RYNNIQLPSA
160 170 180 190 200
LGFFGGSRFV PIVTSFSSIL IGFVFFVIWP PFQQLLVSTG GYISQAGPIG
210 220 230 240 250
TFLYGFLMRL SGAVGLHHII YPMFWYTELG GVETVAGQTV VGAQKIFFAQ
260 270 280 290 300
LADPAHSGLF TEGTRFFAGR FSTMMFGLPA ACLAMYHSVP KNRRKKYAGL
310 320 330 340 350
FFGVALTSFI TGITEPIEFM FLFVSPVLYV VHAFLDGVSF FIADVLNISI
360 370 380 390 400
GNTFSGGVID FTLFGILQGN AKTNWVLQIP FGLIWSVLYY IIFRWFITQF
410 420 430 440 450
NVLTPGRGEE VDSKEISESA DSTSNTADYL KQDSLQIIRA LGGSNNIEDV
460 470 480 490 500
DACVTRLRVA VKEVNQVDKA LLKQIGAVDV LEVKGGIQAI YGAKAILYKN
510
SINEILGVDD
Length:510
Mass (Da):55,033
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A34BA199F15DF33
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE007317 Genomic DNA Translation: AAL00332.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G98062

NCBI Reference Sequences

More...
RefSeqi
NP_359121.1, NC_003098.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL00332; AAL00332; spr1528

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spr:spr1528

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|171101.6.peg.1648

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA Translation: AAL00332.1
PIRiG98062
RefSeqiNP_359121.1, NC_003098.1

3D structure databases

SMRiQ8DNU7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi171101.spr1528

Genome annotation databases

EnsemblBacteriaiAAL00332; AAL00332; spr1528
KEGGispr:spr1528
PATRICifig|171101.6.peg.1648

Phylogenomic databases

eggNOGiCOG1263, Bacteria
COG1264, Bacteria
HOGENOMiCLU_012312_1_0_9
OMAiEPIEYSF

Family and domain databases

CDDicd00212, PTS_IIB_glc, 1 hit
Gene3Di3.30.1360.60, 1 hit
InterProiView protein in InterPro
IPR036878, Glu_permease_IIB
IPR018113, PTrfase_EIIB_Cys
IPR003352, PTS_EIIC
IPR013013, PTS_EIIC_1
IPR001996, PTS_IIB_1
PfamiView protein in Pfam
PF00367, PTS_EIIB, 1 hit
PF02378, PTS_EIIC, 1 hit
SUPFAMiSSF55604, SSF55604, 1 hit
TIGRFAMsiTIGR00826, EIIB_glc, 1 hit
PROSITEiView protein in PROSITE
PS51098, PTS_EIIB_TYPE_1, 1 hit
PS01035, PTS_EIIB_TYPE_1_CYS, 1 hit
PS51103, PTS_EIIC_TYPE_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8DNU7_STRR6
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8DNU7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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