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Entry version 96 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Penicillin-binding protein 2a

Gene

pbp2a

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell wall formation. Synthesis of cross-linked peptidoglycan (PG) from the lipid intermediates (By similarity).

Binds dansylated lipid II and catalyzes the polymerization of glycan chains (PubMed:12867450, PubMed:22487093).

Hydrolyzes S2d (N-benzoyl-D-alanylmercaptoacetic acid) molecule, a synthetic thiolester analog of cell wall stem peptide (PubMed:10217767, PubMed:22487093).

Active against bocillin, a fluorescent penicillin. No transpeptidase activity with non-fluorescent lysine-containing lipid II as substrate (PubMed:22487093).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Optimal transglycosylase/glycosyltransferase (GT) activity in the presence of 30-40% dimethylsulfoxide and 0.002% Triton X-100. High GT activity in the presence of CHAPS, Triton X-100 and n-dodecyl-beta-D-maltopyranoside (DDM) detergents, and to a lesser extent in the presence of Cymal-5 (PubMed:22487093). GT activity is inhibited by moenomycin (PubMed:12867450, PubMed:22487093). 50% inhibition of the GT activity with 2.8 µM moenomycin. No effect on GT activity detected with 2.8 µM vancomycin, but complete inhibition with 28 µM vancomycin (PubMed:12867450). No GT activity in the presence of n-octyl-beta-D-glucopyranoside, Cymal-3 and Cymal-4 detergents (PubMed:22487093).2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is greater than 0.0005 sec(-1) with dansylated lipid II as substrate (PubMed:22487093). kcat/KM is 0.001 M(-1)sec(-1) with dansylated lipid II as substrate (PubMed:12867450).2 Publications
  1. KM=40.6 µM for dansylated lipid II1 Publication
  1. Vmax=0.38 nmol/min/mg enzyme with lysine-dansylated lipid II as substrate (at pH 7.5 and 30 degrees Celsius in the presence of 25% dimethylsulfoxide and 0.04 Triton X-100)1 Publication
  2. Vmax=403 nmol/min/mg enzyme for the hydrolysis of S2d (N-benzoyl-D-alanylmercaptoacetic acid) (at pH 7.0 and 37 degrees Celsius)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.Curated
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei131Proton donor; for transglycosylase activity1 Publication1
Active sitei410Acyl-ester intermediate; for transpeptidase activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Carboxypeptidase, Glycosyltransferase, Hydrolase, Multifunctional enzyme, Protease, Transferase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SPNE171101:SPR1823-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00219

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT51, Glycosyltransferase Family 51

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Penicillin-binding protein 2a4 Publications
Short name:
PBP2a4 Publications
Alternative name(s):
Cell wall synthase PBP2aCurated
Including the following 2 domains:
Penicillin-insensitive transglycosylaseCurated (EC:2.4.1.1292 Publications)
Alternative name(s):
Peptidoglycan TGaseCurated
Peptidoglycan glycosyltransferaseCurated
Penicillin-sensitive transpeptidaseCurated (EC:3.4.16.42 Publications)
Alternative name(s):
DD-transpeptidaseCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pbp2aImported
Ordered Locus Names:spr1823Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri171101 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000586 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 56CytoplasmicSequence analysis3 PublicationsAdd BLAST56
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei57 – 77Helical; Signal-anchor for type II membrane proteinSequence analysis3 PublicationsAdd BLAST21
Topological domaini78 – 731ExtracellularSequence analysis3 PublicationsAdd BLAST654

Keywords - Cellular componenti

Cell membrane, Cell wall, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Transglycosylase/glycosyltransferase (GT) domain of this protein may be an alternative target for the development of new inhibitors of S.pneumoniae as the beta-lactam antibiotics targeted against the transpeptidase domain of this protein have increasing resistance.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi131E → Q: Loss of transglycosylase activity with dansylated lipid II as substrate. 1 Publication1

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01163, Amdinocillin
DB00415, Ampicillin
DB08795, Azidocillin
DB00456, Cefalotin
DB00493, Cefotaxime
DB01331, Cefoxitin
DB00567, Cephalexin
DB03313, Cephalosporin C
DB01147, Cloxacillin
DB00485, Dicloxacillin
DB00739, Hetacillin
DB01603, Meticillin
DB00607, Nafcillin
DB00713, Oxacillin
DB00319, Piperacillin

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004529731 – 731Penicillin-binding protein 2aAdd BLAST731

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. May also form higher order oligomers. Self-association may depend on its transmembrane and/or cytoplasmic regions (PubMed:22487093).

Interacts with MacP; interaction is required for the function of this protein (By similarity).

By similarity1 Publication

Protein-protein interaction databases

Molecular INTeraction database

More...
MINTi
Q8DNB6

STRING: functional protein association networks

More...
STRINGi
171101.spr1823

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8DNB6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni78 – 300Transglycosylase2 PublicationsAdd BLAST223
Regioni78 – 156Hydrophobic; associated with cytoplasmic membrane. Required for transglycosylase activity, but not for lipid II binding2 PublicationsAdd BLAST79
Regioni301 – 731Transpeptidase2 PublicationsAdd BLAST431

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Has a penicillin-insensitive transglycosylase/glycosyltransferase (GT) N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (PubMed:10217767, PubMed:12867450, PubMed:22487093). Transmembrane signal-anchor is required for the synthesis of longer, 20-30 disaccharide units containing, glycan chains (PubMed:22487093).3 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 51 family.Curated
In the C-terminal section; belongs to the transpeptidase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0744, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006354_2_2_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
KVYARPL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3810.10, 1 hit
3.40.710.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012338, Beta-lactam/transpept-like
IPR001264, Glyco_trans_51
IPR023346, Lysozyme-like_dom_sf
IPR036950, PBP_transglycosylase
IPR001460, PCN-bd_Tpept

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00912, Transgly, 1 hit
PF00905, Transpeptidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53955, SSF53955, 1 hit
SSF56601, SSF56601, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8DNB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLDKLFEKF LSLFKKETSE LEDSDSTILR RSRSDRKKLA QVGPIRKFWR
60 70 80 90 100
RYHLTKIILI LGLSAGLLVG IYLFAVAKST NVNDLQNALK TRTLIFDREE
110 120 130 140 150
KEAGALSGQK GTYVELTDIS KNLQNAVIAT EDRSFYKNDG INYGRFFLAI
160 170 180 190 200
VTAGRSGGGS TITQQLAKNA YLSQDQTVER KAKEFFLALE LSKKYSKEQI
210 220 230 240 250
LTMYLNNAYF GNGVWGVEDA SKKYFGVSAS EVSLDQAATL AGMLKGPELY
260 270 280 290 300
NPLNSVEDST NRRDTVLQNM VAAGYIDKNQ ETEAAEVDMT SQLHDKYEGK
310 320 330 340 350
ISDYRYPSYF DAVVNEAVSK YNLTEEEIVN NGYRIYTELD QNYQANMQIV
360 370 380 390 400
YENTSLFPRA EDGTFAQSGS VALEPKTGGV RGVVGQVADN DKTGFRNFNY
410 420 430 440 450
ATQSKRSPGS TIKPLVVYTP AVEAGWALNK QLDNHTMQYD SYKVDNYAGI
460 470 480 490 500
KTSREVPMYQ SLAESLNLPA VATVNDLGVD KAFEAGEKFG LNMEKVDRVL
510 520 530 540 550
GVALGSGVET NPLQMAQAYA AFANEGLMPE AHFISRIENA SGQVIASHKN
560 570 580 590 600
SQKRVIDKSV ADKMTSMMLG TFTNGTGISS SPADYVMAGK TGTTEAVFNP
610 620 630 640 650
EYTSDQWVIG YTPDVVISHW LGFPTTDENH YLAGSTSNGA AHVFRNIANT
660 670 680 690 700
ILPYTPGSTF TVENAYKQNG IAPANTKRQV QTNDNSQTDD NLSDIRGRAQ
710 720 730
SLVDEASRAI SDAKIKEKAQ TIWDSIVNLF R
Length:731
Mass (Da):80,799
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i159DA81430EEEFDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti704D → N in CAA05303 (PubMed:9537382).Curated1
Sequence conflicti731R → H in CAA05303 (PubMed:9537382).Curated1

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 80797 Da. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ002292 Genomic DNA Translation: CAA05303.1
AE007317 Genomic DNA Translation: AAL00626.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E98099

NCBI Reference Sequences

More...
RefSeqi
NP_359415.1, NC_003098.1
WP_000762624.1, NC_003098.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL00626; AAL00626; spr1823

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
60233563

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spr:spr1823

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|171101.6.peg.1967

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002292 Genomic DNA Translation: CAA05303.1
AE007317 Genomic DNA Translation: AAL00626.1
PIRiE98099
RefSeqiNP_359415.1, NC_003098.1
WP_000762624.1, NC_003098.1

3D structure databases

SMRiQ8DNB6
ModBaseiSearch...

Protein-protein interaction databases

MINTiQ8DNB6
STRINGi171101.spr1823

Chemistry databases

DrugBankiDB01163, Amdinocillin
DB00415, Ampicillin
DB08795, Azidocillin
DB00456, Cefalotin
DB00493, Cefotaxime
DB01331, Cefoxitin
DB00567, Cephalexin
DB03313, Cephalosporin C
DB01147, Cloxacillin
DB00485, Dicloxacillin
DB00739, Hetacillin
DB01603, Meticillin
DB00607, Nafcillin
DB00713, Oxacillin
DB00319, Piperacillin

Protein family/group databases

CAZyiGT51, Glycosyltransferase Family 51

Genome annotation databases

EnsemblBacteriaiAAL00626; AAL00626; spr1823
GeneIDi60233563
KEGGispr:spr1823
PATRICifig|171101.6.peg.1967

Phylogenomic databases

eggNOGiCOG0744, Bacteria
HOGENOMiCLU_006354_2_2_9
OMAiKVYARPL

Enzyme and pathway databases

UniPathwayiUPA00219
BioCyciSPNE171101:SPR1823-MONOMER

Family and domain databases

Gene3Di1.10.3810.10, 1 hit
3.40.710.10, 1 hit
InterProiView protein in InterPro
IPR012338, Beta-lactam/transpept-like
IPR001264, Glyco_trans_51
IPR023346, Lysozyme-like_dom_sf
IPR036950, PBP_transglycosylase
IPR001460, PCN-bd_Tpept
PfamiView protein in Pfam
PF00912, Transgly, 1 hit
PF00905, Transpeptidase, 1 hit
SUPFAMiSSF53955, SSF53955, 1 hit
SSF56601, SSF56601, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPBP2A_STRR6
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8DNB6
Secondary accession number(s): O70039
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 2, 2021
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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