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Protein

ATP synthase subunit alpha

Gene

atpA

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.UniRule annotation
The complex from the organism is particularly stable to disruption and remains functional after 6 hrs at 55 degrees Celsius.1 Publication

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Activity regulationi

Inhibited by dicyclohexylcarbodiimide.

Temperature dependencei

Optimum temperature is 55 degrees Celsius, activity was detected from 4 to 95 degrees Celsius.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei363Required for activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi170 – 177ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTELO197221:G1G3I-449-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alphaUniRule annotation (EC:3.6.3.14UniRule annotation)
Alternative name(s):
ATP synthase F1 sector subunit alphaUniRule annotation
F-ATPase subunit alphaUniRule annotation
Gene namesi
Name:atpAUniRule annotation
Ordered Locus Names:tlr0435
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeThermosynechococcus
Proteomesi
  • UP000000440 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CF(1), Membrane, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002383761 – 503ATP synthase subunit alphaAdd BLAST503

Proteomic databases

PRIDEiQ8DLP3

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has four main subunits: a1, b1, b'1 and c(9-12).1 Publication

Protein-protein interaction databases

STRINGi197221.tlr0435

Structurei

3D structure databases

ProteinModelPortaliQ8DLP3
SMRiQ8DLP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDG Bacteria
COG0056 LUCA
HOGENOMiHOG000130111
KOiK02111
OMAiGNAQIKS
OrthoDBiPOG091H01QH

Family and domain databases

CDDicd01132 F1_ATPase_alpha, 1 hit
Gene3Di1.20.150.20, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_01346 ATP_synth_alpha_bact, 1 hit
InterProiView protein in InterPro
IPR023366 ATP_synth_asu-like_sf
IPR000793 ATP_synth_asu_C
IPR038376 ATP_synth_asu_C_sf
IPR033732 ATP_synth_F1_a
IPR005294 ATP_synth_F1_asu
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF00306 ATP-synt_ab_C, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039088 F_ATPase_subunit_alpha, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00962 atpA, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8DLP3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSIRPDEIS SIIRQQIEQY EQSIKVDNVG TVLQVGDGIA RVYGLDKVMA
60 70 80 90 100
SELVEFEDGT VGIALNLEED NVGVVLMGDG LSIEEGSTVR ATGKIASIPV
110 120 130 140 150
GEAAIGRVVD ALMRPIDGKG EIHTTQSRLI ESPAPGIVQR KSVCEPLQTG
160 170 180 190 200
ITAIDAMIPI GRGQRELIIG DRQTGKTAVA IDTILNQKGQ DVICVYVAIG
210 220 230 240 250
QKASSVAQVV NVLRERGALD YTIVIAANAS DPAALQYLAP YTGATVAEYF
260 270 280 290 300
MYQGKHTLVV YDDLSKQAQA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE
310 320 330 340 350
RAAKLNDALG GGSMTALPVV ETQAGDVSAY IPTNVISITD GQIFLSSDLF
360 370 380 390 400
NAGLRPAINA GISVSRVGSA AQIKAMKQVA GKLKLELAQF DELQAFAQFA
410 420 430 440 450
SDLDKATQNQ LARGQRLREI LKQPQYSPIP VEYQVATIYA GTNGYLDDIP
460 470 480 490 500
VEAVAKFVAG LRDYLRTNKP EYGEIIRTTQ KLDEKAEALL KEAIAEYKAT

FTA
Length:503
Mass (Da):54,305
Last modified:March 1, 2003 - v1
Checksum:i927167949C4601F0
GO

Mass spectrometryi

Molecular mass is 54271 Da from positions 1 - 503. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA Translation: BAC07987.1
RefSeqiNP_681225.1, NC_004113.1
WP_011056290.1, NC_004113.1

Genome annotation databases

EnsemblBacteriaiBAC07987; BAC07987; BAC07987
GeneIDi1012677
KEGGitel:tlr0435
PATRICifig|197221.4.peg.459

Similar proteinsi

Entry informationi

Entry nameiATPA_THEEB
AccessioniPrimary (citable) accession number: Q8DLP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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