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Protein

Polyphosphate kinase

Gene

ppk

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).UniRule annotation

Catalytic activityi

ATP + (phosphate)(n) = ADP + (phosphate)(n+1).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPUniRule annotation1
Metal bindingi373MagnesiumUniRule annotation1
Metal bindingi403MagnesiumUniRule annotation1
Active sitei433Phosphohistidine intermediateUniRule annotation1
Binding sitei466ATPUniRule annotation1
Binding sitei562ATPUniRule annotation1
Binding sitei590ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL216895:G1GJ4-457-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyphosphate kinaseUniRule annotation (EC:2.7.4.1UniRule annotation)
Alternative name(s):
ATP-polyphosphate phosphotransferaseUniRule annotation
Polyphosphoric acid kinaseUniRule annotation
Gene namesi
Name:ppkUniRule annotation
Ordered Locus Names:VV1_0464
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001286681 – 700Polyphosphate kinaseAdd BLAST700

Post-translational modificationi

An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.UniRule annotation

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8DEW2
SMRiQ8DEW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini428 – 462PLD phosphodiesterase 1UniRule annotationAdd BLAST35
Domaini585 – 615PLD phosphodiesterase 2UniRule annotationAdd BLAST31

Sequence similaritiesi

Belongs to the polyphosphate kinase 1 (PPK1) family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105CUU Bacteria
COG0855 LUCA
HOGENOMiHOG000248949
KOiK00937
OMAiHPYESFE
OrthoDBiPOG091H02MN

Family and domain databases

Gene3Di3.30.1840.10, 1 hit
HAMAPiMF_00347 Polyphosphate_kinase, 1 hit
InterProiView protein in InterPro
IPR001736 PLipase_D/transphosphatidylase
IPR003414 PP_kinase
IPR024953 PP_kinase_middle
IPR036830 PP_kinase_middle_dom_sf
IPR025200 PPK_C_dom
IPR025198 PPK_N_dom
IPR036832 PPK_N_dom_sf
PANTHERiPTHR30218 PTHR30218, 1 hit
PfamiView protein in Pfam
PF02503 PP_kinase, 1 hit
PF13090 PP_kinase_C, 1 hit
PF13089 PP_kinase_N, 1 hit
PIRSFiPIRSF015589 PP_kinase, 1 hit
SUPFAMiSSF140356 SSF140356, 1 hit
TIGRFAMsiTIGR03705 poly_P_kin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q8DEW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSADKFYIEK ELSWLSFNER VLQEAADKTV PLIERIRFLG IFSNNLDEFY
60 70 80 90 100
KVRFSDVKRR ILINREQGGN DISKHLLSKM QSKALKLNER FDELYNELIR
110 120 130 140 150
DMARRHIFLV NESQLDEAQQ KWIIKYFQKE VLPHITPLML TDEIDVLQFL
160 170 180 190 200
KDEYAYIAVE LKQQEQAKYA LLEIPTDHLP RFIMVPEQKG KRKKTIILLD
210 220 230 240 250
NIIRFCLNDI FRGFFDYDEL NGYAMKMTRD AEYDLRHEVE YSLLEQMSEG
260 270 280 290 300
LSQRLTALPV RFVYERDMPE DMLKYLCYKL KISHYDSLIP GGRYHNFKDF
310 320 330 340 350
IAFPNVGRDY LENKPLPPLA CADFEGYANA FDAIRNQDIL LHYPYHSFEH
360 370 380 390 400
ITELVRQASF DPKVVSIKIN VYRVAKNSRL MNSLIDAVHN GKRVTVVVEL
410 420 430 440 450
QARFDEEANI EWSKLLTDAG VHVIFGVPGM KIHAKLLLIT RREEQGFVRY
460 470 480 490 500
AHIGTGNFHE RTARIYTDFS LLTADQELAA EVRGVFSYIM NPFRPIKFRH
510 520 530 540 550
LIVSPRNSRS QLYRLLDREI HNAQAGKKAS ITLKVNNLVD KGLISKLYAA
560 570 580 590 600
SSAGVKIRMI IRGMCSLVPG LEGISENIEI ISIIDRFLEH PRVLVVHNDG
610 620 630 640 650
DPQVFISSAD WMERNIDNRI EVMSPVRDAR IKQRIIDILS IQFTDTVKAR
660 670 680 690 700
RIDKEMSNNY VERGNRKKIR SQIAIYDYLK NVEKHTRKQK GQVEPNDNNQ
Length:700
Mass (Da):81,817
Last modified:March 1, 2003 - v1
Checksum:i6519C410D343F5F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA Translation: AAO08986.1
RefSeqiWP_011078562.1, NC_004459.3

Genome annotation databases

EnsemblBacteriaiAAO08986; AAO08986; VV1_0464
KEGGivvu:VV1_0464

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA Translation: AAO08986.1
RefSeqiWP_011078562.1, NC_004459.3

3D structure databases

ProteinModelPortaliQ8DEW2
SMRiQ8DEW2
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO08986; AAO08986; VV1_0464
KEGGivvu:VV1_0464

Phylogenomic databases

eggNOGiENOG4105CUU Bacteria
COG0855 LUCA
HOGENOMiHOG000248949
KOiK00937
OMAiHPYESFE
OrthoDBiPOG091H02MN

Enzyme and pathway databases

BioCyciVVUL216895:G1GJ4-457-MONOMER

Family and domain databases

Gene3Di3.30.1840.10, 1 hit
HAMAPiMF_00347 Polyphosphate_kinase, 1 hit
InterProiView protein in InterPro
IPR001736 PLipase_D/transphosphatidylase
IPR003414 PP_kinase
IPR024953 PP_kinase_middle
IPR036830 PP_kinase_middle_dom_sf
IPR025200 PPK_C_dom
IPR025198 PPK_N_dom
IPR036832 PPK_N_dom_sf
PANTHERiPTHR30218 PTHR30218, 1 hit
PfamiView protein in Pfam
PF02503 PP_kinase, 1 hit
PF13090 PP_kinase_C, 1 hit
PF13089 PP_kinase_N, 1 hit
PIRSFiPIRSF015589 PP_kinase, 1 hit
SUPFAMiSSF140356 SSF140356, 1 hit
TIGRFAMsiTIGR03705 poly_P_kin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPPK1_VIBVU
AccessioniPrimary (citable) accession number: Q8DEW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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