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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:VV1_0540
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761631 – 226Uracil-DNA glycosylaseAdd BLAST226

Structurei

3D structure databases

ProteinModelPortaliQ8DEP7
SMRiQ8DEP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF
OrthoDBiPOG091H03VL

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8DEP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQQLTWHDV IGAEKEQSYF QQTLNFVEAE RQAGKVIYPP AKDVFNAFRY
60 70 80 90 100
TEFQDVKVVI LGQDPYHGPN QAHGLCFSVL PGIKTPPSLV NMYKELAQDI
110 120 130 140 150
QGFQIPAHGY LEAWAKQGVL LLNTVLTVEQ GKAHSHASLG WETFTDKVIE
160 170 180 190 200
AINQHQQGVV FLLWGSHAQK KGRFIDRHKH VVLTAPHPSP LSAHRGFLGC
210 220
KHFSQANQHL LDQGKQAIDW QLPLSL
Length:226
Mass (Da):25,447
Last modified:March 1, 2003 - v1
Checksum:i79EA62429D37730F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA Translation: AAO09057.1
RefSeqiWP_011078627.1, NC_004459.3

Genome annotation databases

EnsemblBacteriaiAAO09057; AAO09057; VV1_0540
GeneIDi2623424
KEGGivvu:VV1_0540

Similar proteinsi

Entry informationi

Entry nameiUNG_VIBVU
AccessioniPrimary (citable) accession number: Q8DEP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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