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Protein

DNA polymerase IV

Gene

dinB

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12MagnesiumUniRule annotation1
Sitei17Substrate discriminationUniRule annotation1
Metal bindingi107MagnesiumUniRule annotation1
Active sitei108UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase IVUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IVUniRule annotation
Gene namesi
Name:dinBUniRule annotation
Ordered Locus Names:VV1_1830
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001739641 – 354DNA polymerase IVAdd BLAST354

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8DBI7
SMRiQ8DBI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 189UmuCUniRule annotationAdd BLAST182

Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQ3 Bacteria
COG0389 LUCA
HOGENOMiHOG000082707
KOiK02346
OMAiDMQSFYA
OrthoDBiPOG091H014I

Family and domain databases

CDDicd03586 PolY_Pol_IV_kappa, 1 hit
Gene3Di3.30.1490.100, 1 hit
HAMAPiMF_01113 DNApol_IV, 1 hit
InterProiView protein in InterPro
IPR036775 DNA_pol_Y-fam_lit_finger_sf
IPR017961 DNA_pol_Y-fam_little_finger
IPR022880 DNApol_IV
IPR001126 UmuC
PfamiView protein in Pfam
PF00817 IMS, 1 hit
PF11799 IMS_C, 1 hit
SUPFAMiSSF100879 SSF100879, 1 hit
PROSITEiView protein in PROSITE
PS50173 UMUC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8DBI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQMRKIIH IDMDCFYAAV EMRDNPNFRS RPLAVGGHEK QRGVISTCNY
60 70 80 90 100
EARKFGVRSA MPTAQALKLC PSLLVVPGRM QVYKEVSTHI RSIFSRYTHL
110 120 130 140 150
IEPLSLDEAY LDVTDSTQCH GSATLIAEAI RRDIWNELQL TASAGVAPIK
160 170 180 190 200
FLAKVASDMN KPNGQFVIPP EQVQSVIDTL PLQKIPGVGK VSLEKLNQAG
210 220 230 240 250
LYVCQDVKNS DYRQLLKQFG RLGASLWQRS HGIDEREVIV ERERKSVGVE
260 270 280 290 300
RTFTQNIVTY EQCWQVIEEK LFPELAIRLE KANPEKAIIK QGIKMKFADF
310 320 330 340 350
QLTTIEHVHH ELELAYFREL LQDILQRQKG REIRLLGLSV MLKPEEQARQ

LSLL
Length:354
Mass (Da):40,382
Last modified:July 25, 2003 - v2
Checksum:i0927ED457E635F15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA Translation: AAO10236.2
RefSeqiWP_011079736.1, NC_004459.3

Genome annotation databases

EnsemblBacteriaiAAO10236; AAO10236; VV1_1830
GeneIDi2625389
KEGGivvu:VV1_1830

Similar proteinsi

Entry informationi

Entry nameiDPO4_VIBVU
AccessioniPrimary (citable) accession number: Q8DBI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 25, 2003
Last modified: March 28, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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