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Protein

Molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25GTPUniRule annotation1
Binding sitei53GTPUniRule annotation1
Binding sitei70GTPUniRule annotation1
Metal bindingi100MagnesiumUniRule annotation1
Binding sitei100GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 14GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:VV1_2573
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001349231 – 195Molybdenum cofactor guanylyltransferaseAdd BLAST195

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8D9M4.
SMRiQ8D9M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6R. Bacteria.
COG0746. LUCA.
HOGENOMiHOG000280423.
KOiK03752.
OMAiFVPCDVP.
OrthoDBiPOG091H05CW.

Family and domain databases

CDDicd02503. MobA. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA. 1 hit.
InterProiView protein in InterPro
IPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF12804. NTP_transf_3. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR02665. molyb_mobA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8D9M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQPTLTSWV ILAGGQASRM GGKDKGLIAL NNKPLIEYVI DRLTPQTSNI
60 70 80 90 100
LINANRNQDD YQQYGPVFGD HFQNFPGPMG GIHAGLLHAS TDWVGFVPCD
110 120 130 140 150
CPRINEDLVE RFCRAVTDET DILVAHDGNH QQPVFTLYHK RVLPKLTAFL
160 170 180 190
ERGDRKIILL YKECHTQYVD FSDSPDCFVN LNTPEELTQF GQLES
Length:195
Mass (Da):21,989
Last modified:April 30, 2003 - v2
Checksum:iD58BE7D8AC8E653F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO10924.2.

Genome annotation databases

EnsemblBacteriaiAAO10924; AAO10924; VV1_2573.
KEGGivvu:VV1_2573.

Similar proteinsi

Entry informationi

Entry nameiMOBA_VIBVU
AccessioniPrimary (citable) accession number: Q8D9M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: October 25, 2017
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program