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Protein

Acetate kinase 2

Gene

ackA2

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase 2 (ackA2), Acetate kinase 1 (ackA1)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10MagnesiumUniRule annotation1
Binding sitei17ATPUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Active sitei147Proton donor/acceptorUniRule annotation1
Sitei179Transition state stabilizerUniRule annotation1
Sitei240Transition state stabilizerUniRule annotation1
Metal bindingi385MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi207 – 211ATPUniRule annotation5
Nucleotide bindingi281 – 283ATPUniRule annotation3
Nucleotide bindingi329 – 333ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00340;UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinase 2UniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
Acetokinase 2UniRule annotation
Gene namesi
Name:ackA2UniRule annotation
Ordered Locus Names:VV2_0148
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001076421 – 397Acetate kinase 2Add BLAST397

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8D7K4
SMRiQ8D7K4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
HOGENOMiHOG000288398
KOiK00925
OMAiCERIALD
OrthoDBiPOG091H02K4

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8D7K4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNSFVLVIN SGSSSLKFAV INSVTGEAVL SGLGECFGLE DARMGWKYSG
60 70 80 90 100
EKTEIAIEGE DNHHKIAIGK LVGLTEELGL TKDIVAVGHR IVHGGEKFTS
110 120 130 140 150
TVRINEEVTA EIEKLADLAP LHNPAGAIGI RAAMEAFPAL PQFAVFDTAF
160 170 180 190 200
HQTMPKRAFT GAIANELYTD FGIRRYGFHG TSHYFVSREA AKMLNKPIEE
210 220 230 240 250
SSFISVHLGN GASVCAINNG ESVDTSMGFT PLSGLMMGTR CGDLDPGIIE
260 270 280 290 300
YLLKKGWSQE KVFNSLNKAS GFLGVSGLTS DARGILEAME QGHEGATLAF
310 320 330 340 350
QVFTYRVAKY IASYLAALDS FDGIIFTGGI GENSLPIRRE ILKNLKLLGF
360 370 380 390
VEDEKGNEDA RFGNAGVIAT SALLNAVAMV IPTNEEFVIA QQSVELL
Length:397
Mass (Da):42,595
Last modified:March 1, 2003 - v1
Checksum:i338D8558CC8AF001
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016796 Genomic DNA Translation: AAO07121.1
RefSeqiWP_011081130.1, NC_004460.2

Genome annotation databases

EnsemblBacteriaiAAO07121; AAO07121; VV2_0148
GeneIDi2622622
KEGGivvu:VV2_0148

Similar proteinsi

Entry informationi

Entry nameiACKA2_VIBVU
AccessioniPrimary (citable) accession number: Q8D7K4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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