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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei602For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:BRA0582, BS1330_II0577
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000007104 Componenti: Chromosome II

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353102 – 607Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST606

Proteomic databases

PRIDEiQ8CY30

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8CY30
SMRiQ8CY30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 217Glutamine amidotransferase type-2UniRule annotationAdd BLAST216
Domaini283 – 422SIS 1UniRule annotationAdd BLAST140
Domaini455 – 597SIS 2UniRule annotationAdd BLAST143

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CY30-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIIGIIGN DEVAPRLVDA LKRLEYRGYD SAGIATLQNG RLDRRRAEGK
60 70 80 90 100
LVNLEKRLAG EPLPGVIGIG HTRWATHGRP VERNAHPHIT TRLAVVHNGI
110 120 130 140 150
IENFAELRAM LEAEGRKFET ETDTEAVAHL VTRELEKGKS PVEAVRDCLP
160 170 180 190 200
HLKGAFALAF LFEGDEELLI GARQGPPLAV GYGEGEMFLG SDAIALAPFT
210 220 230 240 250
DTISYLEDGD WAVLTRNGVS IYDENNKPVE RPVQKSQNTN MLVSKGNHRH
260 270 280 290 300
FMQKEMFEQP EVISHTLANY LDFTTGKVRK EAIGIDFSKV DRLTITACGT
310 320 330 340 350
AYYAATVAKY WFEQIARLPV DSDIASEFRY REMPLSKDSL AMFVSQSGET
360 370 380 390 400
ADTLASLRYC KAQGLKIASV VNVTGSTIAR ESDAVFPTLA GPEIGVASTK
410 420 430 440 450
AFTCQLSAMA SLAIAAARAR GAIDEVREQE LVHQLSEAPR FINQVLKLED
460 470 480 490 500
QIAAVCHDLS KVNHVLYLGR GTSFPLAMEG ALKLKEISYI HAEGYAAGEL
510 520 530 540 550
KHGPIALIDE TMPVIVIAPS DRLYEKTVSN MQEVAARGGR IILITDKKGA
560 570 580 590 600
ESASIDTMAT IVLPEVPEFI SPLVYALPIQ MLAYHTAVLM GTDVDQPRNL

AKSVTVE
Length:607
Mass (Da):66,307
Last modified:January 23, 2007 - v3
Checksum:iA1C65B027B5BBCED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA Translation: AAN33771.1
CP002998 Genomic DNA Translation: AEM20048.1
RefSeqiWP_004689005.1, NZ_KN046805.1

Genome annotation databases

EnsemblBacteriaiAAN33771; AAN33771; BRA0582
AEM20048; AEM20048; BS1330_II0577
KEGGibms:BRA0582
bsi:BS1330_II0577
PATRICifig|204722.21.peg.560

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA Translation: AAN33771.1
CP002998 Genomic DNA Translation: AEM20048.1
RefSeqiWP_004689005.1, NZ_KN046805.1

3D structure databases

ProteinModelPortaliQ8CY30
SMRiQ8CY30
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8CY30

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN33771; AAN33771; BRA0582
AEM20048; AEM20048; BS1330_II0577
KEGGibms:BRA0582
bsi:BS1330_II0577
PATRICifig|204722.21.peg.560

Phylogenomic databases

HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGLMS_BRUSU
AccessioniPrimary (citable) accession number: Q8CY30
Secondary accession number(s): G0KCW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 92 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
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Main funding by: National Institutes of Health

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