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Entry version 110 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Urocanate reductase

Gene

urdA

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the two-electron reduction of urocanate to dihydrourocanate (also named imidazole propionate or deamino-histidine). The physiological electron donor is unknown; it might be the membrane-bound tetraheme cytochrome c (CymA). Enables anaerobic growth with urocanate as a sole terminal electron acceptor, and thus can provide the cells with a niche where no other bacteria can compete and survive. Is unable to reduce cinnamate and other unsaturated organic acids such as acrylic, crotonic, fumaric and orotic acids. Has no fumarate reductase or succinate dehydrogenase activity.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

KM for urocanate is inferior to 10 µM and kcat is 360 sec(-1) (at pH 7.0).1 Publication

      Sites

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei143FAD; via amide nitrogenBy similarity1
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei411Proton donorBy similarity1
      Binding sitei550FADBy similarity1

      Regions

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi162 – 163FADBy similarity2
      Nucleotide bindingi170 – 177FADBy similarity8
      Nucleotide bindingi565 – 566FADBy similarity2

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      GO - Biological processi

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionOxidoreductase
      LigandFAD, Flavoprotein, FMN

      Enzyme and pathway databases

      BioCyc Collection of Pathway/Genome Databases

      More...
      BioCyci
      MetaCyc:MONOMER-17916
      SONE211586:G1GMP-4269-MONOMER

      BRENDA Comprehensive Enzyme Information System

      More...
      BRENDAi
      1.3.99.33, 5706

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      Urocanate reductase (EC:1.3.99.33)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:urdA
      Ordered Locus Names:SO_4620
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiShewanella oneidensis (strain MR-1)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri211586 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000008186 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      Keywords - Cellular componenti

      Cell membrane, Membrane

      <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

      <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

      In the urdA-deficient strain, the urocanate reductase activity measured in the crude extract from cells anaerobically grown on a mixture of urocanate and fumarate (or urocanate and nitrate) is about 20-fold lower than in the wild-type. This strain is not affected in its ability to grow in the presence of fumarate, but fails to grow anaerobically on urocanate.1 Publication

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20PROSITE-ProRule annotationAdd BLAST20
      <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042194621 – 582Urocanate reductaseAdd BLAST562

      Amino acid modifications

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi21N-palmitoyl cysteinePROSITE-ProRule annotation1
      Lipidationi21S-diacylglycerol cysteinePROSITE-ProRule annotation1

      Keywords - PTMi

      Lipoprotein, Palmitate, Phosphoprotein

      Proteomic databases

      PaxDb, a database of protein abundance averages across all three domains of life

      More...
      PaxDbi
      Q8CVD0

      <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

      <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

      By urocanate under anaerobic conditions.1 Publication

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      Protein-protein interaction databases

      STRING: functional protein association networks

      More...
      STRINGi
      211586.SO_4620

      <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

      3D structure databases

      SWISS-MODEL Repository - a database of annotated 3D protein structure models

      More...
      SMRi
      Q8CVD0

      Database of comparative protein structure models

      More...
      ModBasei
      Search...

      Protein Data Bank in Europe - Knowledge Base

      More...
      PDBe-KBi
      Search...

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

      Keywords - Domaini

      Signal

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...
      eggNOGi
      COG1053, Bacteria
      COG3976, Bacteria

      The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

      More...
      HOGENOMi
      CLU_011398_4_0_6

      Identification of Orthologs from Complete Genome Data

      More...
      OMAi
      MAWAHGA

      Database of Orthologous Groups

      More...
      OrthoDBi
      153138at2

      Database for complete collections of gene phylogenies

      More...
      PhylomeDBi
      Q8CVD0

      Family and domain databases

      Gene3D Structural and Functional Annotation of Protein Families

      More...
      Gene3Di
      3.50.50.60, 1 hit
      3.90.700.10, 1 hit

      Integrated resource of protein families, domains and functional sites

      More...
      InterProi
      View protein in InterPro
      IPR003953, FAD-binding_2
      IPR036188, FAD/NAD-bd_sf
      IPR010960, Flavocytochrome_c
      IPR007329, FMN-bd
      IPR027477, Succ_DH/fumarate_Rdtase_cat_sf

      Pfam protein domain database

      More...
      Pfami
      View protein in Pfam
      PF00890, FAD_binding_2, 1 hit
      PF04205, FMN_bind, 1 hit

      Simple Modular Architecture Research Tool; a protein domain database

      More...
      SMARTi
      View protein in SMART
      SM00900, FMN_bind, 1 hit

      Superfamily database of structural and functional annotation

      More...
      SUPFAMi
      SSF51905, SSF51905, 1 hit
      SSF56425, SSF56425, 1 hit

      TIGRFAMs; a protein family database

      More...
      TIGRFAMsi
      TIGR01813, flavo_cyto_c, 1 hit

      PROSITE; a protein domain and family database

      More...
      PROSITEi
      View protein in PROSITE
      PS51257, PROKAR_LIPOPROTEIN, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

      Q8CVD0-1 [UniParc]FASTAAdd to basket
      « Hide
              10         20         30         40         50
      MHYKKSIIGI AVTATAIIAG CQVTHQIVKS QGTAQGKHGE VQVETTFKDG
      60 70 80 90 100
      HIVAIDVLKQ KENKVLAGAV FKDVKQAIID NNSIEVDGIA GATVTSKALK
      110 120 130 140 150
      EAVGKSIEAA GVTLVATASA KKSEALTPAE YTYDVVIIGS GGAGFSAGLE
      160 170 180 190 200
      AIAAGRSAVI IEKMPIIGGN SLISGAEMNV AGSWVQKNMG ITDSKELFIS
      210 220 230 240 250
      DTLKGGDFKG DPEMVKTMVD NAVGAAEWLR DYVKVEFYPD QLFQFGGHSV
      260 270 280 290 300
      KRALIPKGHT GAEVISKFSI KADEVGLPIH TNTKAEKLIQ DQTGRIVGVE
      310 320 330 340 350
      AAHNGKTITY HAKRGVVIAT GGFSSNMEMR KKYNPELDER YGSTGHAGGT
      360 370 380 390 400
      GDGIVMAEKI HAAAKNMGYI QSYPICSPTS GAIALIADSR FFGAVLINQK
      410 420 430 440 450
      GERFVEELER RDVISHAILA QPGRYTYVLW NQDIENVAHT VEMHQGELKE
      460 470 480 490 500
      FTKDGLMYKV DTLEEAAKVF NIPEDKLLST IKDVNHYAAT GKDEAFNHRS
      510 520 530 540 550
      GLVDLSKGPY WILKATPSVH HTMGGLVVDT RTRVLDEQGK VIPGLFAAGE
      560 570 580
      VTGLTHGTNR LGGNAYTDII VYGRIAGQEA AK
      Length:582
      Mass (Da):62,235
      Last modified:March 1, 2003 - v1
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFDFB3DEB620EF361
      GO

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...
      EMBLi

      GenBank nucleotide sequence database

      More...
      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...
      DDBJi
      Links Updated
      AE014299 Genomic DNA Translation: AAN57580.1

      NCBI Reference Sequences

      More...
      RefSeqi
      NP_720136.1, NC_004347.2
      WP_011074216.1, NZ_CP053946.1

      Genome annotation databases

      KEGG: Kyoto Encyclopedia of Genes and Genomes

      More...
      KEGGi
      son:SO_4620

      Pathosystems Resource Integration Center (PATRIC)

      More...
      PATRICi
      fig|211586.12.peg.4477

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      AE014299 Genomic DNA Translation: AAN57580.1
      RefSeqiNP_720136.1, NC_004347.2
      WP_011074216.1, NZ_CP053946.1

      3D structure databases

      Select the link destinations:

      Protein Data Bank Europe

      More...
      PDBei

      Protein Data Bank RCSB

      More...
      RCSB PDBi

      Protein Data Bank Japan

      More...
      PDBji
      Links Updated
      PDB entryMethodResolution (Å)ChainPositionsPDBsum
      6T85X-ray1.10A130-582[»]
      6T86X-ray2.56A130-582[»]
      6T87X-ray1.56A130-582[»]
      6T88X-ray1.40A130-582[»]
      SMRiQ8CVD0
      ModBaseiSearch...
      PDBe-KBiSearch...

      Protein-protein interaction databases

      STRINGi211586.SO_4620

      Proteomic databases

      PaxDbiQ8CVD0

      Genome annotation databases

      KEGGison:SO_4620
      PATRICifig|211586.12.peg.4477

      Phylogenomic databases

      eggNOGiCOG1053, Bacteria
      COG3976, Bacteria
      HOGENOMiCLU_011398_4_0_6
      OMAiMAWAHGA
      OrthoDBi153138at2
      PhylomeDBiQ8CVD0

      Enzyme and pathway databases

      BioCyciMetaCyc:MONOMER-17916
      SONE211586:G1GMP-4269-MONOMER
      BRENDAi1.3.99.33, 5706

      Family and domain databases

      Gene3Di3.50.50.60, 1 hit
      3.90.700.10, 1 hit
      InterProiView protein in InterPro
      IPR003953, FAD-binding_2
      IPR036188, FAD/NAD-bd_sf
      IPR010960, Flavocytochrome_c
      IPR007329, FMN-bd
      IPR027477, Succ_DH/fumarate_Rdtase_cat_sf
      PfamiView protein in Pfam
      PF00890, FAD_binding_2, 1 hit
      PF04205, FMN_bind, 1 hit
      SMARTiView protein in SMART
      SM00900, FMN_bind, 1 hit
      SUPFAMiSSF51905, SSF51905, 1 hit
      SSF56425, SSF56425, 1 hit
      TIGRFAMsiTIGR01813, flavo_cyto_c, 1 hit
      PROSITEiView protein in PROSITE
      PS51257, PROKAR_LIPOPROTEIN, 1 hit

      MobiDB: a database of protein disorder and mobility annotations

      More...
      MobiDBi
      Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiURDA_SHEON
      <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CVD0
      <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2013
      Last sequence update: March 1, 2003
      Last modified: June 2, 2021
      This is version 110 of the entry and version 1 of the sequence. See complete history.
      <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programProkaryotic Protein Annotation Program

      <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      3D-structure, Reference proteome

      Documents

      1. PDB cross-references
        Index of Protein Data Bank (PDB) cross-references
      2. SIMILARITY comments
        Index of protein domains and families
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