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Protein

Orotate phosphoribosyltransferase

Gene

pyrE

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei945-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei985-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei1005-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei124OrotateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPyrimidine biosynthesis
LigandMagnesium

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-887-MONOMER
UniPathwayiUPA00070; UER00119

Names & Taxonomyi

Protein namesi
Recommended name:
Orotate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.10UniRule annotation)
Short name:
OPRTUniRule annotation
Short name:
OPRTaseUniRule annotation
Gene namesi
Name:pyrEUniRule annotation
Ordered Locus Names:SE_0881
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001107421 – 203Orotate phosphoribosyltransferaseAdd BLAST203

Proteomic databases

PRIDEiQ8CSW7

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi176280.SE0881

Structurei

3D structure databases

ProteinModelPortaliQ8CSW7
SMRiQ8CSW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 1285-phosphoribose 1-diphosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG41065E1 Bacteria
COG0461 LUCA
KOiK00762
OMAiHAAWVSE

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit
PROSITEiView protein in PROSITE
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CSW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNIAKALL DIEAVSLSPN DLFTWSSGIK SPIYCDNRIT LGYPEVRNAI
60 70 80 90 100
RDGLIQLIKE HFSNVEIISG TATAGIPHAA YISEKLELPM NYVRSKSKSH
110 120 130 140 150
GKQNQIEGAK SENKNVVVVE DLISTGGSSI TAVEALEEAG ANVLGVVAIF
160 170 180 190 200
TYGLAKADKT FNKAHIPFYT LSDYNELIEV AKDEGKISLN DIQTLVDWRD

NLS
Length:203
Mass (Da):22,140
Last modified:March 1, 2003 - v1
Checksum:i04DE28263151A4C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO04478.1
RefSeqiNP_764436.1, NC_004461.1
WP_001830179.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO04478; AAO04478; SE_0881
GeneIDi1056218
KEGGisep:SE0881
PATRICifig|176280.10.peg.853

Entry informationi

Entry nameiPYRE_STAES
AccessioniPrimary (citable) accession number: Q8CSW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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