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Protein

Alcohol dehydrogenase

Gene

adh

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi37Zinc 1; catalyticBy similarity1
Metal bindingi58Zinc 1; catalyticBy similarity1
Metal bindingi89Zinc 2By similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi145Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-377-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Short name:
ADH
Gene namesi
Name:adh
Ordered Locus Names:SE_0375
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002730421 – 340Alcohol dehydrogenaseAdd BLAST340

Proteomic databases

PRIDEiQ8CQ56

Interactioni

Protein-protein interaction databases

STRINGi176280.SE0375

Structurei

3D structure databases

ProteinModelPortaliQ8CQ56
SMRiQ8CQ56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DQ4 Bacteria
COG1064 LUCA
KOiK13953
OMAiARIPKEC

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR029752 D-isomer_DH_CS1
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CQ56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAAVVTKDH RVSIEEKRLR ELRPGEALVK TEYCGVCHTD LHVKNADFGD
60 70 80 90 100
VTGVTLGHEG IGRVIKIADN VDSLKVGDRV SIAWMYAACG NCEYCTTGRE
110 120 130 140 150
TLCRDVLNAG YTVDGAMAEE VIVDANYAVK VPENLDPAAA SSITCAGVTT
160 170 180 190 200
YKAVKVSGIE PGQWLGVFGV GGLGNLALQY AKNVMGAKVV AFDINDDKLN
210 220 230 240 250
FAKELGADAI INSTNVDPIE EVNRLTNNKG LDATVITAVA KTPFNQAVDV
260 270 280 290 300
VKAGARVVAV GLPVDKMDLD IPRLVLDGIE VVGSLVGTRQ DLREAFQFAA
310 320 330 340
ENKVIPKIQL RQLSEINDIF DEMEKGTITG RMVIDMKSTH
Length:340
Mass (Da):36,520
Last modified:March 1, 2003 - v1
Checksum:iE95B6D9BE5CD0C3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO03972.1
RefSeqiNP_763930.1, NC_004461.1
WP_002438761.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO03972; AAO03972; SE_0375
GeneIDi1056765
KEGGisep:SE0375
PATRICifig|176280.10.peg.350

Similar proteinsi

Entry informationi

Entry nameiADH_STAES
AccessioniPrimary (citable) accession number: Q8CQ56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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